mSphere, Journal Year: 2021, Volume and Issue: 6(2)
Published: April 20, 2021
Pregnant women worldwide have been affected by COVID-19. As the virus is commonly spread to various organs via bloodstream and because human placental trophoblasts are directly bathed in maternal blood, feto-placental infection SARS-CoV-2 seems likely.
Language: Английский
Viruses, Journal Year: 2022, Volume and Issue: 14(8), P. 1744 - 1744
Published: Aug. 9, 2022
Porcine epidemic diarrhea virus (PEDV) has been endemic in most parts of the world since its emergence 1970s. It infects small intestine and intestinal villous cells, spreads rapidly, causes infectious disease characterized by vomiting, diarrhea, dehydration, leading to high mortality newborn piglets causing massive economic losses pig industry. The entry PEDV into cells is mediated binding spike protein (S protein) a host cell receptor. Here, we review structure PEDV, strains, function S shared coronaviruses, summarize progress research on possible receptors discovery PEDV.
Language: Английский
Citations
65
Frontiers in Molecular Biosciences, Journal Year: 2021, Volume and Issue: 8
Published: Aug. 30, 2021
The ongoing pandemic illustrates limited therapeutic options for controlling SARS-CoV-2 infections, calling a need additional targets. viral spike S glycoprotein binds to the human receptor angiotensin-converting enzyme 2 (ACE2) and then is activated by host proteases. Based on accessibility of cellular proteases needed SARS-S activation, entrance activation can be mediated endosomal (such as cathepsin L) non-endosomal pathways. Evidence indicates that in pathway, protein cleaved furin infected cells. To help virus enter efficiently, further serine protease (TMPRSS2), provided has been previously. In this review, important roles within cells will outlined infection antiviral strategies highlighted. Although there are at least five highly effective vaccines time, appearance new mutations demands development agents. Targeted inhibition used approach infection.
Language: Английский
Citations
64
Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 137, P. 111313 - 111313
Published: Feb. 5, 2021
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed can inhibit both infection replication even potentially relieve cytokine storms other related complications. Meanwhile, host-targeted drugs cellular transmembrane serine protease (TMPRSS2) prevent from entering cells, its combination with chloroquine dihydroorotate dehydrogenase (DHODH) inhibitors limit spread reduce morbidity mortality patients COVID-19. present article provides an overview these based on insights medicinal chemistry research focuses RNA-dependent RNA polymerase (RdRp) inhibitors, such as nucleoside analogues remdesivir, favipiravir ribavirin. This review also covers 3C-like (3CL
Language: Английский
Citations
62
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12
Published: March 25, 2022
COVID-19 is threatening human health worldwide but no effective treatment currently exists for this disease. Current therapeutic strategies focus on the inhibition of viral replication or using anti-inflammatory/immunomodulatory compounds to improve host immunity, not both. Traditional Chinese medicine (TCM) could be promising candidates due their safety and minimal toxicity. In study, we have developed a novel in silico bioinformatics workflow that integrates multiple databases predict use honeysuckle ( Lonicera japonica ) Huangqi Astragalus membranaceus as potential anti-SARS-CoV-2 agents. Using extracts from Huangqi, these two herbs upregulated group microRNAs including let-7a , miR-148b miR-146a which are critical reduce pathogenesis SARS-CoV-2. Moreover, suppressed pro-inflammatory cytokines IL-6 TNF-α, were both identified cytokine storm acute respiratory distress syndrome, major cause death. Furthermore, partially inhibited fusion SARS-CoV-2 spike protein-transfected BHK-21 cells with lung cancer cell line Calu-3 was expressing ACE2 receptors. These M pro activity, thereby alleviating entry well replication. conclusion, our findings demonstrate used an inhibitor virus warrants further vivo analysis functional assessment miRNAs confirm clinical importance. This fast-screening platform can also applied other drug discovery studies infectious diseases.
Language: Английский
Citations
62
mSphere, Journal Year: 2021, Volume and Issue: 6(2)
Published: April 20, 2021
Pregnant women worldwide have been affected by COVID-19. As the virus is commonly spread to various organs via bloodstream and because human placental trophoblasts are directly bathed in maternal blood, feto-placental infection SARS-CoV-2 seems likely.
Language: Английский
Citations
59