Dorsal BNST DRD2+ neurons mediate sex-specific anxiety-like behavior induced by chronic social isolation DOI Creative Commons

Chaowen Zheng,

Wei Lei, Boyi Liu

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(7), P. 112799 - 112799

Published: July 1, 2023

The dorsal bed nucleus of stria terminalis (dBNST) is a pivotal hub for stress response modulation. Dysfunction dopamine (DA) network associated with chronic stress, but the roles DA dBNST in stress-induced emotional disorders remain unclear. We examine role Drd1+ and Drd2+ neurons post-weaning social isolation (PWSI)-induced behavior deficits. find that male, not female, PWSI rats exhibit negative phenotypes increase excitability E-I balance neurons. More importantly, hypofunction Drd2 receptor underlies PWSI-stress-induced male-specific neuronal plasticity change Furthermore, chemogenetic activation sufficient to induce anxiogenic effects, while Kir4.1-mediated inhibition ameliorate PWSI-induced anxiety-like behaviors. Our findings reveal an important neural mechanism underlying sex-specific behavioral abnormalities potentially provide target treatment stress-related disorder.

Language: Английский

The emergence and influence of internal states DOI Creative Commons
Steven W. Flavell, Nadine Gogolla, Matthew Lovett-Barron

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(16), P. 2545 - 2570

Published: May 27, 2022

Language: Английский

Citations

148
The subthalamic corticotropin-releasing hormone neurons mediate adaptive REM-sleep responses to threat DOI Creative Commons
Yu-Ting Tseng, Binghao Zhao, Shan-Ping Chen

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(7), P. 1223 - 1239.e8

Published: Jan. 21, 2022

Language: Английский

Citations

59
Eye Gaze in Autism Spectrum Disorder: A Review of Neural Evidence for the Eye Avoidance Hypothesis DOI Creative Commons
Nicole Stuart, Andrew J. O. Whitehouse, Romina Palermo

et al.

Journal of Autism and Developmental Disorders, Journal Year: 2022, Volume and Issue: 53(5), P. 1884 - 1905

Published: Feb. 4, 2022

Abstract Reduced eye contact early in life may play a role the developmental pathways that culminate diagnosis of autism spectrum disorder. However, there are contradictory theories regarding neural mechanisms involved. According to amygdala theory autism, reduced results from hypoactive fails flag eyes as salient. avoidance hypothesis proposes opposite—that hyperactivity causes avoidance. This review evaluated studies measured relationship between gaze and activity ‘social brain’ when viewing facial stimuli. Of reviewed studies, eight eleven supported hypothesis. These suggest be used reduce amygdala-related hyperarousal among people on spectrum.

Language: Английский

Citations

52
Chronic pain–induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety DOI Creative Commons
Naoki Yamauchi, Keiichiro Sato,

Kenta Sato

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(17)

Published: April 27, 2022

The comorbidity of chronic pain and mental dysfunctions such as depression anxiety disorders has long been recognized, but the underlying mechanisms remain poorly understood. Here, using a mouse model neuropathic pain, we demonstrated neuronal plasticity in bed nucleus stria terminalis (BNST), which plays critical role pain–induced maladaptive anxiety. Electrophysiology that increased inhibitory inputs to lateral hypothalamus (LH)–projecting BNST neurons. Chemogenetic manipulation revealed sustained suppression LH-projecting neurons played crucial Furthermore, molecular genetic approach, elevated excitability specific subpopulation neurons, express cocaine- amphetamine-regulated transcript (CART). CART-positive caused thereby inducing anxiety-like behavior. These findings shed light on how induces psychiatric disorders, characterized by

Language: Английский

Citations

50
A lamprey neural cell type atlas illuminates the origins of the vertebrate brain DOI Creative Commons
Francesco Lamanna, Francisca Hervas-Sotomayor, A. Phillip Oel

et al.

Nature Ecology & Evolution, Journal Year: 2023, Volume and Issue: 7(10), P. 1714 - 1728

Published: Sept. 14, 2023

Abstract The vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire sea lamprey—a jawless species whose phylogenetic position affords reconstruction ancestral traits—based on extensive single-cell RNA-seq situ sequencing data. Comparisons this to neural data from mouse other jawed vertebrates unveiled various shared features that enabled types, tissue structures gene expression programs brain. However, our analyses also revealed key tissues types arose later evolution. For example, was probably devoid cerebellar oligodendrocytes (myelinating cells); suggest latter astrocyte-like precursors lineage. Altogether, work illuminates architecture provides foundation for exploring diversification during

Language: Английский

Citations

30
Coordination of social behaviors by the bed nucleus of the stria terminalis DOI
Meghan E. Flanigan, Thomas L. Kash

European Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 55(9-10), P. 2404 - 2420

Published: Oct. 2, 2020

The bed nucleus of the stria terminalis (BNST) is a sexually dimorphic, neuropeptide-rich node extended amygdala that has been implicated in responses to stress, drugs abuse, and natural rewards. Its function dysregulated neuropsychiatric disorders are characterized by stress- or drug-induced alterations mood, arousal, motivation, social behavior. However, compared BNST's role its behavior remained relatively understudied. Moreover, precise cell types circuits underlying have only recently begun be explored using modern neuroscience techniques. Here, we systematically review existing literature investigating neurobiological substrates within BNST contribute coordination various sex-dependent sex-independent behavioral repertoires, focusing largely on pharmacological circuit-based studies rodents. We suggest coordinates promoting appropriate assessment contexts select relevant outputs disruption socially systems stress abuse may an important factor development dysfunction disorders.

Language: Английский

Citations

59
Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding DOI Creative Commons
Andrew T. Luskin, Dionnet L. Bhatti, Bernard Mulvey

et al.

Science Advances, Journal Year: 2021, Volume and Issue: 7(9)

Published: Feb. 26, 2021

Circuit dissection techniques reveal that extended amygdala-brainstem circuitry integrates threat and feeding behavior.

Language: Английский

Citations

52
PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology DOI Creative Commons
Zheng Chen, Mincheng Yu,

Jiuliang Yan

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: March 24, 2021

Cholangiocarcinoma was a highly malignant liver cancer with poor prognosis, and immune infiltration status considered an important factor in response to immunotherapy. In this investigation, we tried locate related genes of cholangiocarcinoma through combination bulk-sequencing single-cell sequencing technology. Single sample gene set enrichment analysis used annotate datasets TCGA CHOL, GSE32225, GSE26566. Differentially expressed between high- low-infiltrated groups dataset were yielded further compressed other two backward stepwise regression R environment. Single-cell data GSE138709 loaded by Seurat software examined the expression infiltration-related set. Pathway changes cell populations analyzed scTPA web tool. There 43 differentially low-immune infiltrated patients, after compression, PNOC LAIR2 significantly correlated high cholangiocarcinoma. Through data, mainly B cells tumor microenvironment, while Treg partial GZMB+ CD8 T cells, which survival increased tissues. High levels better overall survival. Also, demonstrated functionally different roles progression. biomarkers for evaluation PNOC, could predict potential marker exhaustive populations, correlating worse patients.

Language: Английский

Citations

43
BNST PKCδ neurons are activated by specific aversive conditions to promote anxiety-like behavior DOI
Kellie M. Williford, Anne Taylor, James R. Melchior

et al.

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(7), P. 1031 - 1041

Published: March 20, 2023

Language: Английский

Citations

22
Threat and Reward Imminence Processing in the Human Brain DOI Creative Commons
Dinavahi V. P. S. Murty, Songtao Song, Srinivas Govinda Surampudi

et al.

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(16), P. 2973 - 2987

Published: March 16, 2023

In the human brain, aversive and appetitive processing have been studied with controlled stimuli in rather static settings. addition, extent to which aversive-related appetitive-related engage distinct or overlapping circuits remains poorly understood. Here, we sought investigate dynamics of while male female participants engaged comparable trials involving threat avoidance reward seeking. A central goal was characterize temporal evolution responses during periods imminence. For example, domain, predicted that bed nucleus stria terminalis (BST), but not amygdala, would exhibit anticipatory given role former anxious apprehension. We also periaqueductal gray (PAG) threat-proximity based on its involvement proximal-threat processes, ventral striatum threat-imminence escape rodents. Overall, uncovered imminence-related temporally increasing ("ramping") multiple brain regions, including BST, PAG, striatum, subcortically, dorsal anterior insula midcingulate, cortically. Whereas generated proximity as expected, it exhibited threat-related imminence responses. fact, across observed a main effect arousal. other words, extensive evolving, both suggesting distributed are dynamically biologically relevant information regardless valence, findings further supported by network analysis.

Language: Английский

Citations

21