Integrated bioinformatics analysis reveals the bidirectional effects of TSPAN6 for cisplatin resistance in lung cancer

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(6)

Published: June 1, 2024

Cisplatin-based chemotherapy is frequently employed as the primary therapeutic approach for advanced lung cancer. Nevertheless, a significant proportion of patients may develop resistance to cisplatin, leading diminished efficacy chemotherapy. Through analysis Gene Expression Omnibus databases, TSPAN6 has been identified key factor in conferring attributed its activation NF-κB signaling pathway. Knockdown using siRNA resulted decreased expression levels A549 cells. This indicates that have dual effects on cancer cisplatin and could serve promising target individuals with resistance.

Language: Английский

Exploring Oxysterols and Protein Carbonylation in Cervicovaginal Secretions as Biomarkers for Cervical Cancer Development

Advances in Redox Research, Journal Year: 2024, Volume and Issue: 13, P. 100111 - 100111

Published: Aug. 12, 2024

Cervical cancer, a major global health issue and the fourth most common cancer among women, is strongly linked to Human Papillomavirus (HPV) infection. Emerging evidence indicates that oxidative stress plays critical role in carcinogenesis of cervical tissue. This study investigates relationship between markers—specifically oxysterols, lipid oxidation, protein carbonylation—and progression neoplasia. Oxysterols, which are elevated various inflammatory diseases cancers, were measured cervicovaginal fluid samples using LC-MS/MS. The targeted oxysterols included 27-hydroxycholesterol (27-OHC), 7β-hydroxycholesterol (7β-OHC), 7-ketocholesterol (7-KC), 7α,27-dihydroxycholesterol (7α,27-diOHC). Among these, was significantly increased correlation with severity neoplastic stages. In parallel, carbonylation, an indicator cellular stress, assessed. Results revealed higher levels carbonylation compared non-neoplastic controls. These modifications further analysed through redox proteomics identify specific proteins affected. demonstrates oxidation secretions development cancer. Identifying these biomarkers may improve screening strategies, enabling identification individuals at risk for neoplasia guiding timely interventions.

Language: Английский

Oxysterols in tumor immune microenvironment (TIME)

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 245, P. 106634 - 106634

Published: Nov. 16, 2024

Language: Английский