Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue DOI Creative Commons
Maria Vamvini, Pasquale Nigro, Tiziana Caputo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 18, 2023

ABSTRACT Exercise training and cold exposure both improve systemic metabolism, but the mechanisms are not well-established. We tested hypothesis that adaptations to inguinal white adipose tissue (iWAT) critical for these beneficial effects by determining impact of exercise-trained cold-exposed iWAT on glucose metabolism proteome secretome. Transplanting trained into sedentary mice improved tolerance, while transplantation showed no such benefit. Compared training, led more pronounced alterations in secretome, downregulating >2,000 proteins also boosting iWAT’s thermogenic capacity. In contrast, only increased extracellular space vesicle transport proteins, upregulated correlate with favorable fasting glucose, suggesting fundamental changes mediate tissue-to-tissue communication. This study defines unique exercise training- exposure-induced proteomes, revealing distinct interventions metabolic health. GRAPHICAL

Language: Английский

Exercise induces tissue-specific adaptations to enhance cardiometabolic health DOI Creative Commons
Stephen P. Ashcroft, Ben Stocks, Brendan Egan

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 278 - 300

Published: Jan. 5, 2024

The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause mortality is decreased in individuals who meet the current recommendations for physical activity. Therefore, regular exercise remains a cornerstone prevention treatment of non-communicable diseases. An acute bout results coordinated interaction between tissues to increased energy demand exercise. Over time, metabolic stress each individual provides basis long-term adaptations across tissues, including system, skeletal muscle, adipose tissue, liver, pancreas, gut, brain. plethora benefits throughout whole body, improved cardiorespiratory fitness, function, glycemic control. Overall, we summarize exercise-induced that occur within how they converge ultimately improve cardiometabolic health.

Language: Английский

Citations

33
Metabolic interplays between the tumour and the host shape the tumour macroenvironment DOI
Patricia Altea‐Manzano, Amanda R. Decker-Farrell, Tobias Janowitz

et al.

Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

2
Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C DOI
Yang Li, Ruo-Ying Li,

Jieying Zhu

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

2
Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training DOI Creative Commons
Mark Viggars,

Hannah E Berko,

Stuart J. Hesketh

et al.

Molecular Metabolism, Journal Year: 2024, Volume and Issue: 86, P. 101980 - 101980

Published: June 29, 2024

In this investigation, we addressed the contribution of core circadian clock factor, BMAL1, in skeletal muscle to both acute transcriptional responses exercise and remodeling response training. Additionally, adopted a systems biology approach investigate how loss BMAL1 altered peripheral tissue homeostasis as well training adaptations iWAT, liver, heart, lung male mice.

Language: Английский

Citations

8
Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice DOI Creative Commons
Cheukyau Luk, Katherine Bridge, Nele Warmke

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Abstract During recent decades, changes in lifestyle have led to widespread nutritional obesity and its related complications. Remodelling adipose tissue as a therapeutic goal for complications has attracted much attention continues be actively explored. The endothelium lines all blood vessels is close cells, including adipocytes. been suggested act paracrine organ. We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), modulator white phenotype. show that reduction IGF-1R expression presence high-fat feeding male mice leads depot-specific beneficial remodelling, increases whole-body energy expenditure enhances insulin sensitivity via non-cell-autonomous mechanism. demonstrate increased malonate may contributory prodrugs potentially therapeutically relevant properties treatment obesity-related metabolic disease.

Language: Английский

Citations

1
Mouse models for metabolic health research: molecular mechanism of exercise effects on health improvement through adipose tissue remodelling DOI Open Access
H. Kim, Youn Ju Kim, Je Kyung Seong

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Exercise provides health benefits to multiple metabolic tissues through complex biological pathways and interactions between organs. However, investigating these mechanisms in humans is still limited, making mouse models extremely useful for exploring exercise-induced changes whole-body metabolism health. In this review, we focus on gaining a broader understanding of the phenotypes molecular induced by exercise models. We first discuss differences adaptations aerobic resistance exercise, compare voluntary wheel running forced treadmill two main methods research mice, show similarities same but different methods, their impact experimental outcomes. The effects phenotypes, including alleviation obesity disorders, involved adipose tissue remodelling browning are explored, as well role gut microbiota mediating physiological responses exercise. Understanding methodological aspects experiments can serve valuable template design future basic physiology will provide strong scientific evidence base optimizing intervention programmes

Language: Английский

Citations

1
Brown adipose tissue and aging: A potential role for exercise DOI Creative Commons
Shinsuke Nirengi, Kristin I. Stanford

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 178, P. 112218 - 112218

Published: May 29, 2023

Aging is one of the primary risk factors for development type 2 diabetes and cardiovascular disease, regular physical activity can help to delay, prevent, or manage onset many chronic diseases present in older adults. Brown adipose tissue (BAT) thermogenic that protects against age-related but BAT decreases with age. In this review, we discuss how aging contributes impaired function by inducing a 'whitening' altering beta 3 adrenergic receptor (β

Language: Английский

Citations

16
The Sympathetic Innervation of Adipose Tissues: Regulation, Functions, and Plasticity DOI
Jake W. Willows, Magdalena Blaszkiewicz, Kristy L. Townsend

et al.

Comprehensive physiology, Journal Year: 2023, Volume and Issue: unknown, P. 4985 - 5021

Published: June 26, 2023

The sympathetic nervous system (SNS) is a crucial arm of the peripheral (PNS) and includes catecholaminergic neurons that release norepinephrine (NE) onto numerous effector tissues organs in body. SNS innervation both white (WAT) brown adipose tissue (BAT) clearly essential for proper function metabolic control, as decades surgical, chemical, genetic denervation studies have demonstrated. Despite our vast knowledge about innervation, especially context cold-stimulated browning thermogenesis are under newer data now provide nuanced view supply to adipose, including its regulation by local neuroimmune cells neurotrophic factors, co-release modulatory neuropeptides along with NE, importance drive versus systemic increases circulating catecholamines, long-overlooked interplay between sensory nerves. This article brings modern patterns WAT BAT, how image quantify nerve supply, contributions functions, nerves respond remodeling plasticity changing energy demands. © 2023 American Physiological Society. Compr Physiol 13:4985-5021, 2023.

Language: Английский

Citations

15
From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling DOI Creative Commons
Nathaniel Vo, Qiwei Zhang, Hoon‐Ki Sung

et al.

Journal of Pharmacy & Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 27

Published: July 22, 2024

Obesity, characterised by excessive fat accumulation, is a complex chronic condition that results from dysfunctional adipose tissue expansion due to prolonged calorie surplus. This leads rapid adipocyte enlargement exceeds the support capacity of surrounding neurovascular network, resulting in increased hypoxia, inflammation, and insulin resistance. Intermittent fasting (IF), dietary regimen cycles between periods eating, has emerged as an effective strategy combat obesity improve metabolic homeostasis promoting healthy remodeling. However, precise molecular cellular mechanisms behind improvements remodeling white (WAT) driven IF remain elusive. review aims summarise discuss relationship explore potential through which induces alterations WAT. includes several key structural changes, including angiogenesis sympathetic innervation We will also involvement signalling pathways, such PI3K, SIRT, mTOR, AMPK, potentially play crucial role IF-mediated adaptations.

Language: Английский

Citations

5
Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation DOI Creative Commons
Dandan Jia, Huijie Zhang, Tiemin Liu

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(3), P. 135 - 135

Published: Feb. 22, 2024

Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose health mitigate the effects of aging. However, molecular mechanisms underlying benefits regular on aging function remain poorly understood. Adipokines released through play potential role mitigating enhancing metabolism glucose lipids, reducing inflammation fibrosis, promoting fat browning thermogenesis. This review comprehensively summarizes addressing age-related decline Utilizing relevant examples this approach, we address possibility designing therapeutic interventions based these mechanisms.

Language: Английский

Citations

3