A Markovian neural barcode representing mesoscale cortical spatiotemporal dynamics. DOI

J. Culp,

Donovan M. Ashby,

Antis G. George

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract Mesoscale cortical dynamics consist of stereotyped patterns recurring activity motifs, however the constraints and rules governing how these motifs assemble over time is not known. Here we propose a Continuous Time Markov Chain model that probabilistically describes temporal sequence using Elements derived semi-binary non-negative matrix factorization. Although from discovery sample, can be applied to new recordings mice. Unwrapping associated transition probability creates ‘Markovian neural barcode’ describing element transitions as compact interpretable representation neocortical dynamics. We show broad utility across range common mesoscale imaging applications, ranging time-locked events pathological models. Moreover, it allows emergent unmask flexibility The Markovian barcode provides novel powerful tool characterize function.

Language: Английский

A human-specific enhancer fine-tunes radial glia potency and corticogenesis DOI Open Access
J. Liu, Federica Mosti, Hanzhi Zhao

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 11, 2024

Humans evolved an extraordinarily expanded and complex cerebral cortex, associated with developmental gene regulatory modifications

Language: Английский

Citations

6
Mapping brain state-dependent sensory responses across the mouse cortex DOI Creative Commons
Elena Montagni, Francesco Resta, Núria Tort‐Colet

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(5), P. 109692 - 109692

Published: April 9, 2024

Sensory information must be integrated across a distributed brain network for stimulus processing and perception. Recent studies have revealed specific spatiotemporal patterns of cortical activation the early late components sensory-evoked responses, which are associated with features perception, respectively. Here, we investigated how state influences mouse cortex. We utilized isoflurane to modulate conducted wide-field calcium imaging Thy1-GCaMP6f mice monitor evoked by multi-whisker stimulation. Our findings reveal that level anesthesia strongly shapes functional connectivity sensory-activated network. As levels decrease, observe increasingly complex accompanied emergence component within response. The persistence under raises new questions regarding potential existence perception during unconscious states.

Language: Английский

Citations

4
Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation. DOI Creative Commons
Danielle L. Kurtin,

Ketevan Alania,

E. J. Rhodes

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Resting-state metrics, such as brain network activity and functional connectivity (FC), are influenced by preceding cognitive tasks, memory formation. Brain stimulation can modulate FC during the resting state. However, it is unknown whether acutely or traces of tasks. We evaluated non-invasive temporal interference (TI) hippocampus hippocampal resting-state induced a hippocampally-dependent task. collected magnetic resonance imaging (rsfMRI) in twenty healthy participants before after performance an associative Theta-band TI medial anterior hippocampus, sham were delivered post-task used permutation tests to assess differences pairwise mutual information (miFC) between pre-task rsfMRI vs sham. In edges with significantly different pre- miFC, assessed effect on miFC. MiFC was lower several networks compared baseline, including hippocampal-connected task-related Anterior Temporal (AT) Posterior Medial (PM) networks. state increased miFC AT PM well other Non-invasive modulated related hippocampal-dependent

Language: Английский

Citations

0
Task-Related Changes in Resting State Connectivity are Affected by Temporal Interference (Ti) Stimulation DOI
Danielle L. Kurtin,

Ketevan Alania,

E. J. Rhodes

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Static and dynamic resting-state brain activity patterns of table tennis players in 7-Tesla MRI DOI Creative Commons
Yuyang Li, Mengqi Zhao, Yuting Cao

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 14, 2023

Table tennis involves quick and accurate motor responses during training competition. Multiple studies have reported considerably faster visuomotor expertise-related intrinsic brain activity changes among table players compared with matched controls. However, the underlying neural mechanisms remain unclear. Herein, we performed static dynamic resting-state functional magnetic resonance imaging (rs-fMRI) analyses of 20 21 control subjects using 7T ultra-high field imaging. We calculated amplitude low-frequency fluctuations (ALFF) two groups. The results revealed that exhibited decreased ALFF in left inferior temporal gyrus (lITG) group. Voxel-wised connectivity (sFC) (dFC) lITG as seed region afforded complementary overlapping results. sFC right middle parietal gyrus. Conversely, they displayed increased dFC from to prefrontal cortex, particularly frontal gyrus, superior gyrus-medial, gyrus-dorsolateral. These findings suggest demonstrate altered transformation executive function pathways. Both pathways involve lITG, which is a vital node ventral visual stream. provide results, may help us better understand network organization induced by long-term skill training.

Language: Английский

Citations

7
Wide-field imaging in behaving mice as a tool to study cognitive function DOI Creative Commons
Ariel Gilad

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(03)

Published: Feb. 19, 2024

Cognitive functions are mediated through coordinated and dynamic neuronal responses that involve many different areas across the brain. Therefore, it is of high interest to simultaneously record activity from as brain possible while subject performs a cognitive behavioral task. One emerging tools achieve mesoscopic field view wide-field imaging cortex-wide dynamics in mice. Wide-field cost-effective, user-friendly, enables obtaining signals mice performing complex demanding tasks. Importantly, offers an unbiased observation sheds light on overlooked cortical regions highlights parallel processing circuits. Recent studies have shown multi-area patterns, rather than just single area, involved encoding functions. The optical properties enable signals, such layer-specific, inhibitory subtypes, or neuromodulation signals. Here, I review main advantages mice, recent literature, discuss future directions field. It expected behaving will continue gain popularity aid understanding mesoscale underlying function.

Language: Английский

Citations

2
Widefield in vivo imaging system with two fluorescence and two reflectance channels, a single sCMOS detector, and shielded illumination DOI Creative Commons
Patrick Doran,

Natalie Fomin-Thunemann,

Rockwell P. Tang

et al.

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(03)

Published: June 14, 2024

Widefield microscopy of the entire dorsal part mouse cerebral cortex enables large-scale ("mesoscopic") imaging different aspects neuronal activity with spectrally compatible fluorescent indicators as well hemodynamics via oxy- and deoxyhemoglobin absorption. Versatile cost-effective systems are needed for large-scale, color-multiplexed multiple intrinsic contrasts.

Language: Английский

Citations

2
Spectral-switching analysis reveals real-time neuronal network representations of concurrent spontaneous naturalistic behaviors in human brain DOI
Hongkun Zhu, Andrew J. Michalak, Edward M. Merricks

et al.

Published: July 11, 2024

Abstract Despite abundant evidence of functional networks in the human brain, their neuronal underpinnings, and relationships to real-time behavior have been challenging resolve. Analyzing brain-wide intracranial-EEG recordings with video monitoring, acquired awake subjects during clinical epilepsy evaluation, we discovered tendency each brain region switch back forth between 2 distinct power spectral densities (PSDs 2-55Hz). We further recognized that this ‘spectral switching’ occurs synchronously distant sites, even regions differing baseline PSDs, revealing long-range would be obscured analysis individual frequency bands. Moreover, PSD-switching dynamics specific exhibited striking alignment activities such as conversation hand movements, a multi-threaded network representation concurrent naturalistic behaviors. Network structures behaviors were stable across days, but altered N3 sleep. Our results provide new framework for understanding real-time, neural-network dynamics.

Language: Английский

Citations

2
Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging – A Symposium Review DOI Creative Commons

Joshua K Marchant,

Natalie Ferris,

Diana Grass

et al.

Neuroinformatics, Journal Year: 2024, Volume and Issue: 22(4), P. 679 - 706

Published: Sept. 23, 2024

Abstract Advances in the spatiotemporal resolution and field-of-view of neuroimaging tools are driving mesoscale studies for translational neuroscience. On October 10, 2023, Center Mesoscale Mapping (CMM) at Massachusetts General Hospital (MGH) Athinoula A. Martinos Biomedical Imaging Institute Technology (MIT) Health Sciences based Neuroimaging Training Program (NTP) hosted a symposium exploring state-of-the-art this rapidly growing area research. “Mesoscale Brain Mapping: Bridging Scales Modalities Neuroimaging” brought together researchers who use broad range imaging techniques to study brain structure function convergence microscopic macroscopic scales. The day-long event centered on areas which CMM has established expertise, including development emerging technologies their application clinical needs basic neuroscience questions. in-person welcomed more than 150 attendees, 57 faculty members, 61 postdoctoral fellows, 35 students, four industry professionals, represented institutions local, regional, international levels. also served training goals both NTP. content, organization, format were planned collaboratively by trainees. Many presented or participated panel discussion, thus contributing dissemination they have developed under auspices findings obtained using those technologies. NTP trainees benefited from included helped organize and/or posters gave “flash” oral presentations. In addition gaining experience presenting work, had opportunities throughout day engage one-on-one discussions with visiting scientists other faculty, potentially opening door future collaborations. presentations provided deep exploration many technological advances enabling progress structural functional imaging. Finally, students worked closely develop report summarizing content putting it broader context current state field share scientific community. We note that references cited here include conference abstracts corresponding poster

Language: Английский

Citations

2
Flexibility of intrinsic neural timescales during distinct behavioral states DOI Creative Commons
Yasir Çatal, Kaan Keskin, Angelika Wolman

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 19, 2024

Abstract Recent neuroimaging studies demonstrate a heterogeneity of timescales prevalent in the brain’s ongoing spontaneous activity, labeled intrinsic neural (INT). At same time, also reflect stimulus- or task-related activity. The relationship INT during activity with their involvement task states including behavior remains unclear. To address this question, we combined calcium imaging data spontaneously behaving mice and human electroencephalography (EEG) rest computational modeling. We obtained four primary findings: (i) distinct behavioral can be accurately predicted from INT, (ii) become longer compared to rest, (iii) change is correlated negatively variability (iv) mass modeling shows key role recurrent connections mediating rest-task INT. Extending current findings, our results show dynamic nature reflecting continuous through flexible modulation possibly mediated by connections.

Language: Английский

Citations

2