Amygdala and cortex relationships during learning of a sensory discrimination task DOI Creative Commons
David Levitan, Ariel Gilad

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(34), P. e0125242024 - e0125242024

Published: July 18, 2024

During learning of a sensory discrimination task, the cortical and subcortical regions display complex spatiotemporal dynamics. learning, both amygdala cortex link stimulus information to its appropriate association, for example, reward. In addition, structures are also related nonsensory parameters such as body movements licking during reward period. However, emergence cortico-amygdala relationships is largely unknown. To study this, we combined wide-field imaging with fiber photometry simultaneously record population dynamics male mice learn whisker-dependent go/no-go task. We were able neuronal populations from posterior either basolateral (BLA) or central/medial (CEM). Prior somatosensory associative responded sensation, while areas did not show significant responses. As became experts, responses emerged early sensation period, increasing in CEM, decreasing BLA. Interestingly, associated task-related movement, displaying ∼200 ms before movement initiation which led A correlation analysis between revealed negative positive BLA respectively, only expert case. These results imply that induces an involvement may aid stimuli associations.

Language: Английский

Cortex-wide characterization of decision-making neural dynamics during spatial navigation DOI Creative Commons
Samuel P. Haley, Daniel Surinach, Angela K. Nietz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Summary Decision-making during freely moving behaviors involves complex interactions among many cortical and subcortical regions. However, the spatiotemporal coordination across regions to generate a decision is less understood. Using head-mounted widefield microscope, cortex-wide calcium dynamics were recorded in mice expressing GCaMP7f as they navigated an 8-maze using two paradigms. The first was alternating pattern that required short term memory of previous trial make correct second after rule change fixed path which rewards delivered only on left side. Identification activation states revealed differences between There higher probability for visual/retrosplenial state paradigm secondary motor posterior parietal left-only. Three sequences (motifs) illustrated both anterior activity propagations cortex. propagating motifs had highest around peaked following decision. latter, likely reflecting internal feedback influence future actions, more common left-only paradigm. Therefore, probabilities differ when working versus trajectory reward

Language: Английский

Citations

1
Amygdala and cortex relationships during learning of a sensory discrimination task DOI Creative Commons
David Levitan, Ariel Gilad

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(34), P. e0125242024 - e0125242024

Published: July 18, 2024

During learning of a sensory discrimination task, the cortical and subcortical regions display complex spatiotemporal dynamics. learning, both amygdala cortex link stimulus information to its appropriate association, for example, reward. In addition, structures are also related nonsensory parameters such as body movements licking during reward period. However, emergence cortico-amygdala relationships is largely unknown. To study this, we combined wide-field imaging with fiber photometry simultaneously record population dynamics male mice learn whisker-dependent go/no-go task. We were able neuronal populations from posterior either basolateral (BLA) or central/medial (CEM). Prior somatosensory associative responded sensation, while areas did not show significant responses. As became experts, responses emerged early sensation period, increasing in CEM, decreasing BLA. Interestingly, associated task-related movement, displaying ∼200 ms before movement initiation which led A correlation analysis between revealed negative positive BLA respectively, only expert case. These results imply that induces an involvement may aid stimuli associations.

Language: Английский

Citations

0