International Journal of Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 27(9)
Published: Sept. 1, 2024
Osteoarthritis (OA) is a prevalent degenerative disease. We explored the role and regulatory mechanisms of lncRNA-FAS-AS1 in OA progression.
Language: Английский
Life Sciences, Journal Year: 2025, Volume and Issue: 363, P. 123355 - 123355
Published: Jan. 6, 2025
Language: Английский
Citations
1
Cancer Immunology Research, Journal Year: 2024, Volume and Issue: 12(8), P. 1039 - 1057
Published: April 19, 2024
NK cells can be rapidly activated in response to cytokines during host defense against malignant or viral infection. However, it remains unclear what mechanisms precisely and regulate the expression of a large number genes involved activating cells. In this study, we discovered that NK-cell N6-methyladenosine (m6A) methylation levels were upregulated upon short-term activation repressed tumor microenvironment (TME). Deficiency methyltransferase-like 3 (METTL3) METTL14 moderately influenced homeostasis, while double-knockout METTL3/14 more significantly impacted maturation, antitumor immunity. This suggests cooperative role METTL3 regulating development effector functions. Using methylated RNA immunoprecipitation sequencing, demonstrated functions, such as Prf1 Gzmb, directly modified by m6A methylation. Furthermore, inhibiting mTOR complex 1 prevented from increasing when activated, could restored S-adenosylmethionine supplementation. Collectively, have unraveled crucial roles for rapid mRNA downstream 1-S-adenosylmethionine signal axis
Language: Английский
Citations
7
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 14, 2024
Abstract Skeletal system disease (SSD) is defined as a class of chronic disorders skeletal with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position adenosine in RNA, reversible dynamic modification posttranscriptional mRNA. Evidences suggest that m6A modifications play crucial role regulating biological processes all kinds diseases, such malignancy. Recently studies have revealed most abundant epigentic modification, involved progression SSD. However, function SSD not fully illustrated. Therefore, make clear relationship between pathogenesis might provide novel sights for prevention targeted treatment This article will summarize recent advances regulation SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis osteoarthritis, discuss potential clinical value, research challenge future prospect
Language: Английский
Citations
5
Journal of Orthopaedics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123487 - 123487
Published: Feb. 1, 2025
Language: Английский
Citations
0
Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)
Published: March 1, 2025
Osteoarthritis, osteoporosis, and osteosarcoma are prevalent osseous pathologies associated with the aberrant functionality of chondrocytes, osteoclasts, osteoblasts, respectively. These conditions frequently exhibit therapeutic resistance possess a high mortality risk, thus representing substantial health threats. To mitigate these concerns, it is imperative to investigate novel mechanistic insights. Methyltransferase-like 3 (METTL3) pivotal in disorders by modulating gene expression via N6-methyladenosine (m6A) modifications on RNA, thereby impacting cellular processes. Although considerable research has elucidated METTL3's involvement diseases, systematic review essential summarise findings evaluate significance. This endeavours aggregate examine contemporary studies elucidate role bone its clinical implications. We propose that METTL3 constitutes risk mediating m6A both mRNAs non-coding RNAs, suggesting may serve as critical diagnostic biomarker target. In conclusion, this provides an extensive analysis correlation osteoarthritis, osteosarcoma, offering valuable perspectives extant serving reference for researchers engaged basic translational studies.
Language: Английский
Citations
0
Calcified Tissue International, Journal Year: 2025, Volume and Issue: 116(1)
Published: April 3, 2025
Language: Английский
Citations
0
Gene, Journal Year: 2025, Volume and Issue: 959, P. 149518 - 149518
Published: April 18, 2025
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: May 6, 2025
Elucidating the molecular mechanisms underlying orthopedic diseases is crucial for guiding therapeutic strategies and developing innovative interventions. N6-methyladenosine (m6A)-an epitranscriptomic modification-has emerged as a key regulator of cellular fate tissue homeostasis. Specifically, m6A plays pivotal role in several RNA biological processes such precursor splicing, 3'-end processing, nuclear export, translation, stability. Recent advancements indicate that methylation regulates stem cell proliferation osteogenic differentiation by modulating various signaling pathways. Extensive research has shown abnormalities contribute significantly to onset progression osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), bone tumors. This review aims summarize proteases involved their functions. The detailed which marrow mesenchymal cells (BMSCs) through direct indirect ways are also discussed, with focus on specific Finally, this analyzes roles modification development multiple diseases, offering comprehensive understanding pathophysiology these conditions proposing new directions targets treatment strategies.
Language: Английский
Citations
0