Eosinophils Enhance Granuloma-Mediated Control of Persistent Salmonella Infection

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Salmonella enterica can persist asymptomatically within tissues for extended periods. This remarkable feat is achieved through intricate host-pathogen interactions in immune cell aggregates called granulomas, wherein Salmonella find favorable cellular niches to exploit while the host limits its expansion and tissue dissemination. Here, using a mouse model of persistent infection, we identify host-protective role eosinophils control Typhimurium (STm) infection mesenteric lymph nodes (MLN), main lymphoid STm persistence. Combining spatial transcriptomics experimental manipulations, found that macrophages responding recruited C-C motif chemokine ligand 11 (CCL11)-dependent manner enhanced their activation. Eosinophil deficiencies increased burdens, which was associated with altered granuloma size impaired type-1 immunity MLN. Thus, play vital restraining exploitation at key site bacterial

Language: Английский

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Eosinophils as Modulators of Host Defense during Parasitic, Fungal, Bacterial, and Viral Infections

Journal of Leukocyte Biology, Journal Year: 2024, Volume and Issue: 116(6), P. 1301 - 1323

Published: Aug. 13, 2024

Eosinophils, traditionally associated as central innate effector cells with type 2 immunity during allergic and helminth parasitic diseases, have recently been revealed to important roles in tissue homeostasis well host defense a broader variety of infectious diseases. In dedicated session at the 2023 biennial conference International Eosinophil Society titled "Eosinophils Host Defense," multifaceted eosinophils play against diverse pathogens, ranging from parasites fungi, bacteria, viruses, were presented. this review, speakers offer comprehensive summary recent discoveries across pathogen classes, positioning pivotal leukocytes both pathology. By unraveling intricacies eosinophil engagement resistance, exploration may provide valuable insights not only understand specific underpinnings functions related each class pathogens but also develop novel therapeutics effective broad spectrum

Language: Английский

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Eosinophils respond to, but are not essential for control of an acute Salmonella enterica serovar Typhimurium infection in mice

Infection and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

ABSTRACT Eosinophils are a highly abundant cell type in the gastrointestinal tract during homeostatic conditions, where they have recently been reported to take on an activated phenotype following colonization by bacterial microbiota. To date, there few studies investigating whether eosinophils respond infection with enteric pathogens and/or requirements for effective pathogen control. In this study, we investigated response of acute mice Salmonella enterica serovar Typhimurium. We also assessed eosinophil deficiency impacted burdens intestinal or systemic dissemination oral littermate wild-type BALB/cJ and eosinophil-deficient ΔdblGATA mice. found comparable no significant differences levels disseminating organs within 3 days infection. Despite our evidence suggesting that not essential controlling setting, higher gut-draining lymph nodes infection, indicating do Our data contribute growing responsive stimuli, yet influence appear be context-dependent.

Language: Английский

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Eosinophils as drivers of bacterial immunomodulation and persistence

Infection and Immunity, Journal Year: 2024, Volume and Issue: 92(9)

Published: July 15, 2024

ABSTRACT Traditionally, eosinophils have been linked to parasitic infections and pathological disease states. However, emerging literature has unveiled a more nuanced intricate role for these cells, demonstrating their key functions in maintaining mucosal homeostasis. Eosinophils exhibit diverse phenotypes exert multifaceted effects during infections, ranging from promoting pathogen persistence triggering allergic reactions. Our investigations primarily focus on Bordetella spp., with particular emphasis bronchiseptica , natural murine that induces diseases mice akin pertussis humans. Recent findings our published work striking interaction between B. eosinophils, facilitated by the btrS -mediated mechanism. This serves enhance while concurrently delaying adaptive immune responses. Notably, this of is only noted absence functional signaling pathway, indicating wild-type possibly other possess such adeptness manipulating true function cells remains obscured infection. In review, we present mounting evidence pointing toward as targets bacterial exploitation, facilitating fostering chronic sites, including lungs, gut, skin. We underscore pivotal master regulator pathogenesis, sigma factor BtrS, orchestrating eosinophil-dependent immunomodulation within context pulmonary These putative convergent strategies targeting offer promising avenues development novel therapeutics respiratory pathogens.

Language: Английский

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Respiratory Microbiome

Published: Jan. 1, 2024

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