Neocortical somatostatin neuron diversity in cognition and learning
Trends in Neurosciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
A dendritic substrate for temporal diversity of cortical inhibition
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 9, 2024
In
the
mammalian
neocortex,
GABAergic
interneurons
(INs)
inhibit
cortical
networks
in
profoundly
different
ways.
The
extent
to
which
this
depends
on
how
INs
process
excitatory
signals
along
their
dendrites
is
poorly
understood.
Here,
we
reveal
that
functional
specialization
of
two
major
populations
determined
by
unique
association
dendritic
integration
modes
with
distinct
synaptic
organization
motifs.
We
found
somatostatin
(SST)-INs
exhibit
NMDAR-dependent
and
uniform
synapse
density
tree.
contrast,
parvalbumin
(PV)-INs
passive
coupled
proximally
enriched
distributions.
Theoretical
analysis
shows
these
configurations
result
strategies
optimize
efficacy
thin
structures.
Yet,
lead
temporal
engagement
each
IN
during
network
activity.
confirmed
predictions
Language: Английский
Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease
Frontiers in Cellular Neuroscience,
Journal Year:
2025,
Volume and Issue:
18
Published: Jan. 23, 2025
Understanding
cortical
inhibition
and
its
diverse
roles
remains
a
key
challenge
in
neurophysiological
research.
Traditionally,
has
been
recognized
for
controlling
the
stability
rhythmicity
of
network
dynamics,
or
refining
spatiotemporal
properties
representations.
In
this
perspective,
we
propose
that
specific
types
interneurons
may
play
complementary
role,
by
modulating
computational
neural
networks.
We
review
experimental
theoretical
evidence,
mainly
from
rodent
sensory
cortices,
supports
view.
Additionally,
explore
how
dysfunctions
these
disrupt
network’s
ability
to
switch
between
modes,
impacting
flexibility
processing
potentially
contributing
various
neurodevelopmental
psychiatric
disorders.
Language: Английский
Long-lasting, subtype-specific regulation of somatostatin interneurons during sensory learning
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
Somatostatin
(SST)-expressing
inhibitory
neurons
are
a
major
class
of
neocortical
γ-amino
butyric
acid
(GABA)
neurons,
where
morphological,
electrophysiological,
and
transcriptomic
analyses
indicate
more
than
dozen
different
subtypes.
However,
whether
this
diversity
is
related
to
specific
roles
in
cortical
computations
plasticity
remains
unclear.
Here
we
identify
learning-dependent,
subtype-specific
layer
2/3
SST
the
mouse
somatosensory
cortex.
Martinotti-type,
expressing
calbindin-2
show
selective
decrease
excitatory
synaptic
input
stimulus-evoked
calcium
responses
as
mice
learn
stimulus-reward
association.
Using
these
insights,
develop
label-free
classifier
using
basal
activity
from
Language: Английский