A distributed subcortical circuit linked to instrumental information-seeking about threat
Proceedings of the National Academy of Sciences,
Journal Year:
2025,
Volume and Issue:
122(3)
Published: Jan. 15, 2025
Daily
life
for
humans
and
other
animals
requires
switching
between
periods
of
threat-
reward-oriented
behavior.
We
investigated
neural
activity
associated
with
spontaneous
switching,
in
a
naturalistic
task,
foraging
rewards
seeking
information
about
potential
threats
7T
fMRI
healthy
humans.
Switching
was
driven
by
estimates
likelihood
threat
reward.
Both
tracking
to
vigilant
mode
which
people
sought
more
were
specific
but
distributed
patterns
spanning
habenula,
dorsal
raphe
nucleus
(DRN),
anterior
cingulate
cortex,
insula
cortex.
Different
aspects
the
linked
monitoring
level,
threat,
actual
detection.
A
distinct
pattern
same
circuit
elsewhere
occurred
during
returns
Individual
variation
DRN
reflected
individual
threats.
Language: Английский
Opponent control of reinforcement by striatal dopamine and serotonin
Nature,
Journal Year:
2024,
Volume and Issue:
639(8053), P. 143 - 152
Published: Nov. 25, 2024
Language: Английский
Deciphering the Functions of Raphe–Hippocampal Serotonergic and Glutamatergic Circuits and their Deficits in Alzheimer’s Disease
Wanting Yu,
No information about this author
R Zhang,
No information about this author
Aosheng Zhang
No information about this author
et al.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1234 - 1234
Published: Jan. 30, 2025
Subcortical
innervation
of
the
hippocampus
by
raphe
nucleus
is
essential
for
emotional
and
cognitive
control.
The
two
major
afferents
from
to
originate
serotonergic
glutamatergic
neurons,
which
control
hippocampal
inhibitory
network,
theta
activity,
synaptic
plasticity
have
been
extensively
explored
in
growing
body
literature,
whereas
those
circuits
received
little
attention.
Notably,
both
between
are
disrupted
Alzheimer's
disease
(AD),
may
contribute
initiation
progression
behavioral
psychological
symptoms
dementia.
Thus,
deciphering
mechanism
underlying
abnormal
raphe-hippocampal
AD
crucial
prevent
dementia-associated
symptoms.
In
this
review,
we
summarize
anatomical,
neurochemical,
electrophysiological
diversity
nuclei
as
well
architecture
circuitry.
We
then
elucidate
subcortical
activity
their
role
regulation
emotion
cognition.
Additionally,
present
an
overview
pathogenesis
analyze
available
therapies
that
can
potentially
be
used
clinically
alleviate
neuropsychiatric
decline
course.
Language: Английский
A prospective code for value in the serotonin system
Nature,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Language: Английский
Subcortical nuclei of the human ascending arousal system encode anticipated reward but do not predict subsequent memory
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Abstract
Subcortical
nuclei
of
the
ascending
arousal
system
play
an
important
role
in
regulating
brain
and
cognition.
However,
functional
MRI
these
humans
involves
unique
challenges
due
to
their
size
location
deep
within
brain.
Here,
we
used
ultra-high-field
other
methodological
advances
investigate
activity
six
subcortical
during
reward
anticipation
memory
encoding:
locus
coeruleus,
basal
forebrain,
median
dorsal
raphe
nuclei,
substantia
nigra
ventral
tegmental
area.
Participants
performed
a
monetary
incentive
delay
task,
which
successfully
induced
state
anticipation,
24-hour
delayed
surprise
test.
Region-of-interest
analyses
revealed
that
all
increased
potential
rewards
as
opposed
neutral
outcomes.
In
contrast,
none
predicted
performance
24
hours
later.
These
findings
provide
new
insights
into
cognitive
functions
are
supported
by
human
system.
Language: Английский