Cancer Genetics, Journal Year: 2024, Volume and Issue: 292-293, P. 1 - 13
Published: Dec. 29, 2024
Mitochondrial dysregulation contributes to the chemoresistance of multiple cancer types. Yet, functions mitochondrial in Ovarian serous cystadenocarcinoma (OSC) remain largely unknown.
Language: Английский
Cancer Cell, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
1
Trends in cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
1
Stem Cells International, Journal Year: 2024, Volume and Issue: 2024(1)
Published: Jan. 1, 2024
Background: Mesenchymal stem cells (MSCs) have been identified to a unique migratory pattern toward tumor sites across diverse cancer types, playing crucial role in progression, treatment resistance, and immunosuppression. This study aims formulate prognostic model focused on MSC‐associated markers efficiently predict the clinical outcomes responses therapy individuals with bladder (BC). Methods: Clinical transcriptome profiling data were extracted from The Cancer Genome Atlas Urothelial Bladder Carcinoma (TCGA‐BLCA) GSE31684 databases. Systematic quantification of MSC prevalences stromal indices was undertaken, culminating discernment genes correlated MSCs following thorough application weighted gene coexpression network analysis techniques. Subsequently, an exhaustive risk signature pertinent formulated by amalgamating methods univariate Least Absolute Shrinkage Selection Operator (LASSO) Cox regression models. Drugs targeting associated screened using molecular docking. Results: for incorporated five critical genes: ZNF165, matrix remodeling‐associated 7 (MXRA7), CEMIP, ADP‐ribosylation factor‐like 4C (ARL4C), cerebral endothelial cell adhesion molecule (CERCAM). In case BC patients, stratification performed into discrete categories, utilizing median score as criterion. It striking that those classified within high‐MSC‐risk bracket demonstrated correlations unfavorable implications. Enhanced responsiveness immunotherapy low‐MSC‐risk patients delineated compared their counterparts. A heightened receptivity noted particular chemotherapy drugs, encompassing gemcitabine, vincristine, paclitaxel, gefitinib, sorafenib, this high‐risk group. Conversely, superior reaction cisplatin distinctly evident among marked low scores. results docking kaempferol exhibited favorable quercetin MXRA7, mairin limonin diosphenol ARL4C. Conclusions: five‐gene demonstrates substantial efficacy prognosticating gauging regimens. ARL4C, CERCAM are underscored promising candidates warranting further exploration anti‐MSC therapeutic strategies, thereby offering novel insights personalized approaches BC.
Language: Английский
Citations
0
Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)
Published: Nov. 23, 2024
Mitochondria are dynamic organelles integral to metabolic processes, coordination of essential biological pathways, and oncogenesis tumor progression. Recent studies have revealed that mitochondria can be transferred between cells via multiple mechanisms, implicating their involvement in the pathogenesis progression ovarian cancer. This review provides a comprehensive analysis intercellular mitochondrial transfer within context cancer its microenvironment. We also propose targeted pathways therapeutic strategies could utilized modulate diseases associated with therapy. Finally, we examine recent advancements this field identify several unresolved questions.
Language: Английский
Citations
0
Cancer Genetics, Journal Year: 2024, Volume and Issue: 292-293, P. 1 - 13
Published: Dec. 29, 2024
Mitochondrial dysregulation contributes to the chemoresistance of multiple cancer types. Yet, functions mitochondrial in Ovarian serous cystadenocarcinoma (OSC) remain largely unknown.
Language: Английский
Citations
0