Increasing
evidence
has
shown
that
physical
exercise
remarkably
inhibits
oncogenesis
and
progression
of
numerous
cancers
exercise-responsive
microRNAs
(miRNAs)
exert
a
marked
role
in
exercise-mediated
tumor
suppression.
In
this
research,
expression
prognostic
values
miRNAs
were
examined
breast
cancer
(BRCA)
further
pan-cancer
types.
addition,
multiple
independent
public
in-house
cohorts,
vitro
assays
involving
multiple,
macrophages,
fibroblasts,
cells,
vivo
models
utilized
to
uncover
the
tumor-suppressive
roles
miR-29a-3p
cancers.
Here,
we
reported
was
miRNA,
which
lowly
expressed
tissues
associated
with
unfavorable
prognosis
BRCA.
Mechanistically,
targeted
cells
down-regulate
B7
homolog
3
(B7-H3)
expression.
Single-cell
RNA
sequencing
(scRNA-seq)
cytometry
by
time-of-flight
(CyTOF)
demonstrated
attacked
armored
cold
tumors,
thereby
shaping
an
immuno-hot
microenvironment
(TME).
Translationally,
liposomes
developed
loaded
(lipo@miR-29a-3p),
lipo@miR-29a-3p
exhibited
promising
antitumor
effects
mouse
model
great
biocompatibility.
conclusion,
uncovered
is
critical
tumors
inhibiting
B7-H3
Thus,
restoration
could
be
alternative
strategy
for
therapy.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 13, 2024
This
review
critically
evaluates
the
substantial
role
of
exercise
in
enhancing
cancer
prevention,
treatment,
and
patient
quality
life.
It
conclusively
demonstrates
that
regular
physical
activity
not
only
reduces
risk
but
also
significantly
mitigates
side
effects
therapies.
The
key
findings
include
notable
improvements
fatigue
management,
reduction
cachexia
symptoms,
enhancement
cognitive
functions.
Importantly,
elucidates
profound
impact
on
tumor
behavior,
modulation
immune
responses,
optimization
metabolic
pathways,
advocating
for
integration
into
standard
oncological
care
protocols.
refined
abstract
encourages
further
exploration
application
as
a
pivotal
element
management.
World Journal of Psychiatry,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1611 - 1617
Published: Nov. 7, 2024
The
substantial
global
health
burden
of
depression
encourages
the
development
innovative
and
broadly
effective
interventions.
This
paper
aimed
to
examine
recent
advancements
by
which
exercise
works
as
an
antidepressant
recommends
optimal
types
quantity
supplemental
therapies
in
treating
depression.
Sedentary
behavior
low
physical
activity
significantly
influence
onset
Being
treatment
option,
can
reduce
risk.
Exercise
exerts
effects
it
modulates
neurotransmitters,
neuroplasticity,
immune
system,
hormone
levels.
Effective
forms
include
yoga,
strength
training,
walking/jogging.
Tailored
regimens
that
consider
individual
preferences
tolerability
improve
outcomes.
Regular
enhances
general
well-being
reduces
depressive
symptoms.
Additional
research
is
needed
understand
complex
basis
exercise's
on
a
cost-effective
accessible
intervention
for
management
needs
additional
exploration.
Thus,
customized
programs,
per
each
patient’s
needs,
are
essential
their
successful
implementation
clinically.
