Diseases,
Journal Year:
2025,
Volume and Issue:
13(4), P. 120 - 120
Published: April 19, 2025
Background:
This
study
aims
to
identify
the
factors
related
demographic
variables
and
physical
performance
associated
with
quality
of
life
(QoL)
in
post-COVID-19
pa-tients
who
have
recovered
from
mild
infection
were
not
hospitalized.
Methods:
Seventy-four
individuals
COVID-19
infec-tion
assessed
for
baseline
(age,
sex,
height,
weight,
body
mass
index;
BMI)
clinical
information
(comorbidities,
duration
infection,
exercise
habits).
Vital
signs
(heart
rate,
blood
pressure,
oxygen
sat-uration;
SpO2)
measured.
Physical
was
evaluated
upper-
lower-limb
muscle
strength,
ability
balance,
cardiorespiratory
performance.
All
participants
QoL.
Results:
Hand
grip
strength
negatively
asso-ciated
gender
age
while
positively
COVID-19.
Quadricep
also
showed
a
negative
association
Age
multiple
dimensions,
emotional
role
limitations
waist
circumference.
Mental
health
linked
BMI.
Conclusions:
highlights
complex
impact
on
per-formance
QoL,
revealing
that
older
adults
often
report
better
QoL
despite
reduced
particularly
women.
The
findings
emphasize
need
targeted
rehabilitation
programs
addressing
both
vulnerable
groups.
Clinical Nutrition,
Journal Year:
2022,
Volume and Issue:
41(10), P. 2244 - 2263
Published: Aug. 7, 2022
Low
muscle
mass
and
malnutrition
are
prevalent
conditions
among
adults
of
all
ages,
with
any
body
weight
or
index,
acute
chronic
conditions,
including
COVID-19.
This
article
synthesizes
the
latest
research
advancements
in
health
malnutrition,
their
impact
on
immune
function,
clinical
outcomes.
We
provide
a
toolkit
illustrations
scientific
information
that
healthcare
professionals
can
use
for
knowledge
translation,
educating
patients
about
importance
identifying
treating
low
malnutrition.
focus
emerging
evidence
mitochondrial
dysfunction
context
aging
disease,
as
well
cross-talk
between
skeletal
system.
address
myosteatosis
component
composition,
discuss
direct,
indirect
surrogate
assessments
ultrasound,
computerized
tomography,
deuterated
creatine
dilution,
calf
circumference.
Assessments
function
also
included
(handgrip
strength,
physical
performance
tests).
Finally,
we
nutrition
interventions
to
support
anabolism,
reduce
catabolism,
improve
patient
These
include
protein
amino
acids,
branched-chain
leucine;
β-hydroxy-β-methylbutyrate
(HMB),
vitamin
D;
n-3
polyunsaturated
fatty
acids
(n-3
PUFA),
polyphenols,
oral
nutritional
supplements.
concluded
recommendations
practice
call
action
focusing
evaluating
composition
targeted
interventions,
consequently
ability
JAMA Internal Medicine,
Journal Year:
2024,
Volume and Issue:
184(4), P. 414 - 414
Published: Feb. 26, 2024
Importance
COVID-19
infection
is
associated
with
a
high
incidence
of
acute
kidney
injury
(AKI).
Although
rapid
function
decline
has
been
reported
in
the
first
few
months
after
COVID-19−associated
AKI
(COVID-AKI),
longer-term
association
COVID-AKI
remains
unknown.
Objective
To
assess
long-term
outcomes
patients
who
had
AKI.
Design,
Setting,
and
Participants
This
was
retrospective
longitudinal
multicenter
cohort
study
conducted
large
hospital
system
using
electronic
health
records
data
on
adult
hospitalized
or
other
illnesses.
Included
were
during
pandemic
(March
2020-June
2022),
screened
for
SARS-CoV-2,
AKI,
survived
to
discharge,
5
years
before
(October
2016-January
2020),
positive
influenza
A
B
test
result,
discharge.
Patients
followed
up
maximum
2
Data
analyses
performed
from
December
2022
November
2023.
Exposure
influenza.
Main
Outcomes
Measures
The
primary
outcome
major
adverse
events
(MAKE),
defined
as
composite
mortality
worsened
(estimated
glomerular
filtration
rate
[eGFR]
by
≥25%
discharge
eGFR
failure
requiring
dialysis).
Multivariable
time-to-event
compare
MAKE
between
individuals
those
illnesses
same
period.
For
further
comparison,
this
assessed
historic
influenza-associated
Results
included
9624
(mean
[SD]
age,
69.0
[15.7]
years;
4955
[51.5%]
females)
including
987
COVID-AKI,
276
8361
(other-AKI).
Compared
groups,
slightly
younger
higher
baseline
eGFR,
worse
comorbidity
scores,
markers
illness
severity,
longer
stay.
other-AKI
group,
group
lower
(adjusted
hazard
ratio
[aHR],
0.67;
95%
CI,
0.59-0.75)
due
all-cause
(aHR,
0.31;
0.24-0.39)
rates
0.78;
0.69-0.88).
Conclusions
Relevance
findings
indicate
that
survivors
hospitalization
experience
MAKE,
decline,
compared
Journal of Investigative Medicine,
Journal Year:
2023,
Volume and Issue:
71(5), P. 545 - 562
Published: March 6, 2023
In
late
2019,
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
triggered
the
global
disease
2019
(COVID-19)
pandemic.
Although
most
infections
cause
a
self-limited
comparable
to
other
upper
viral
pathogens,
portion
of
individuals
develop
illness
leading
substantial
morbidity
and
mortality.
Furthermore,
an
estimated
10%–20%
SARS-CoV-2
are
followed
by
post-acute
sequelae
COVID-19
(PASC),
or
long
COVID.
Long
COVID
is
associated
with
wide
variety
clinical
manifestations
including
cardiopulmonary
complications,
persistent
fatigue,
neurocognitive
dysfunction.
Severe
hyperactivation
increased
inflammation,
which
may
be
underlying
in
subset
individuals.
However,
immunologic
mechanisms
driving
development
still
under
investigation.
Early
pandemic,
our
group
others
observed
immune
dysregulation
persisted
into
convalescence
after
COVID-19.
We
subsequently
cohort
experiencing
demonstrated
SARS-CoV-2-specific
CD4
+
CD8
T-cell
responses
antibody
affinity
patients
symptoms.
These
data
suggest
symptoms
due
chronic
activation
presence
antigen.
This
review
summarizes
literature
date
detailing
how
these
observations
relate
addition,
we
discuss
recent
findings
support
antigen
evidence
that
this
phenomenon
contributes
local
systemic
inflammation
heterogeneous
nature
seen
Turkish Journal of Physical Medicine and Rehabilitation,
Journal Year:
2023,
Volume and Issue:
1(1), P. 1 - 7
Published: Feb. 28, 2023
The
worldwide
pandemic
of
coronavirus
disease
2019
(COVID-19)
was
known
to
predominantly
affect
the
lungs,
but
it
realized
that
COVID-19
had
a
large
variety
clinical
involvement.
Cardiovascular,
gastrointestinal,
neurological,
and
musculoskeletal
systems
are
involved
by
direct
or
indirect
mechanisms
with
various
manifestations.
involvement
can
manifest
during
infection,
due
medications
used
for
treatment
COVID-19,
in
post/long
syndrome.
major
symptoms
fatigue,
myalgia/arthralgia,
back
pain,
low
chest
pain.
During
last
two
years,
increased,
no
clear
consensus
obtained
about
pathogenesis.
However,
there
is
valuable
data
supports
hypothesis
angiotensinconverting
enzyme
2,
inflammation,
hypoxia,
muscle
catabolism.
Additionally,
were
also
have
adverse
effects,
such
as
corticosteroid-induced
myopathy
osteoporosis.
Therefore,
while
deciding
drugs,
priorities
benefits
should
be
taken
into
consideration.
Symptoms
begin
three
months
from
onset
continue
at
least
months,
cannot
explained
another
diagnosis
accepted
Prior
may
persist
fluctuate,
new
manifest.
In
addition,
must
one
symptom
infection.
Most
common
myalgia,
arthralgia,
weakness,
sarcopenia,
impaired
exercise
capacity,
physical
performance.
female
sex,
obesity,
elderly
patients,
hospitalization,
prolonged
immobility,
having
mechanical
ventilation,
not
vaccination,
comorbid
disorders
predictors
Musculoskeletal
pain
problem
tends
chronic
form.
There
on
mechanism,
inflammation
angiotensin-converting
2
seem
play
an
important
role.
Localized
generalized
occur
after
general
localized
An
accurate
allows
physicians
initiate
management
proper
rehabilitation
programs.
