Published: Jan. 1, 2023
Functional ability and health are some of the factors that change in way a decline ageing process, suggesting older adults within different generational age groups have profiles. This chapter discusses variance response to crises (e.g. coronavirus pandemic, climate change, violence) by who may face levels frailty health. Intergenerational differences resilience autonomy will be emphasized.
Language: Английский
Vaccines, Journal Year: 2023, Volume and Issue: 11(11), P. 1711 - 1711
Published: Nov. 11, 2023
The emergence of Omicron variants coincided with declining vaccine-induced protection against SARS-CoV-2. Two bivalent mRNA vaccines, mRNA-1273.222 (Moderna) and BNT162b2 Bivalent (Pfizer-BioNTech), were developed to provide greater the predominate circulating by including that encodes both ancestral (original) strain BA.4/BA.5. We estimated their relative vaccine effectiveness (rVE) in preventing COVID-19-related outcomes US using a nationwide dataset linking primary care electronic health records pharmacy/medical claims data. study population (aged ≥18 years) received either between 31 August 2022 28 February 2023. used propensity score weighting adjust for baseline differences groups. rVE hospitalizations (primary outcome) outpatient visits (secondary) 1,034,538 1,670,666 recipients, an adjusted 9.8% (95% confidence interval: 2.6–16.4%) 5.1% CI: 3.2–6.9%), respectively, versus Bivalent. incremental was among adults ≥ 65; these patients 13.5% 5.5–20.8%) 10.7% (8.2–13.1%), respectively. Overall, we found compared visits, increased benefits older adults.
Language: Английский
Citations
24
Open Journal of Epidemiology, Journal Year: 2025, Volume and Issue: 15(01), P. 1 - 18
Published: Jan. 1, 2025
The emergence of the SARS-CoV-2 virus resulted in a health and economic crisis worldwide. Although everyone is susceptible to COVID-19, elderly have compromised immune systems often suffer from chronic underlying diseases, which makes them more vulnerable. This study aims assess variation COVID-19 vaccine distribution patterns across different age groups European countries understand extent prioritized vulnerable (age > 70) their vaccination programs. utilized open data Center for Disease Prevention Control (ECDC) employed an observational, retrospective design examine among various several September 2021 2023. Results reveal that rates increase with age, peaking at 25 - 49 group (1.34 × 10−4), after there was decline rate. Analysis variance (ANOVA) used investigate equality 29 Europe, p-value during period as no country achieved 70% coverage aimed by WHO. Continuous efforts must be made ensure larger this population order protect severe outcomes region.
Language: Английский
Citations
1
Frontiers in Aging, Journal Year: 2023, Volume and Issue: 4
Published: Oct. 11, 2023
In the face of global pathogens such as influenza (flu) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), strategies beyond standard vaccines virus-specific treatments are critically needed for older populations who more susceptible to disease death from these infections due age-related immune dysregulation. Thus, complimentary therapeutics address increased risk complications in adults. Metformin, an FDA approved diabetes drug, is attractive therapeutic candidate improve defenses resilience adults facing viral challenge. Metformin already a anti-aging but its benefits have potential span this specific responses. can target multiple aging hallmarks well directly impact innate adaptive cell subsets. Both retrospective prospective studies demonstrated metformin’s efficacy improving outcomes after SARS-CoV-2 or flu infections. Moreover, evidence clinical trials has also suggested that metformin treatment vaccination totality, findings suggest declines immunological resilience. Strategies infection vaccine-induced protection invaluable ability repurpose drug significant advantages terms necessary time resources. great dysregulation during should be further explored confirm overall
Language: Английский
Citations
10
Tropical Diseases Travel Medicine and Vaccines, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 14, 2025
Abstract Background Vaccination against COVID-19 has been the primary public health measure implemented to limit spread of disease. However, there is still considerable scope for improvement in vaccine coverage, particularly sub-Saharan African countries. The factors influencing acceptance or reluctance have widely studied, but a gap literature with regard dynamic populations, travelers, who are one priority target groups vaccination. This study assessed perceptions, attitudes and practices regarding vaccine, explored associated vaccination status among travelers. Methods A cross-sectional survey was conducted at several points entry (PoEs) selected six sites (N’djili airport, Ngobila beach, Lufu, Boma, Moanda, Kananga), located three provinces Democratic Republic Congo (Kinshasa, Kongo Central Kasaï Central), from February 20 March 05, 2023. data were summarized logistic regression models performed assess status. Results total 2742 travelers included this survey. Of these, 54% had received least dose vaccine. Multivariable analyses revealed that significantly These age (under 60 years), marital (single), occupation (other than healthcare worker), mode travel airplane), poor perceptions most frequently cited reasons respondents prevention infection ease travel. In contrast, unvaccinated participants expressed greater concern about safety effectiveness as well vaccine-related side effects. Furthermore, disruption inappropriate identified significant obstacles PoEs. Conclusions It essential awareness initiatives address concerns misconceptions effectiveness. influence social media platforms may be harnessed dissemination accurate information trusted sources, including professionals, population. addition, accompanying measures should considered facilitate compliance different
Language: Английский
Citations
0
Vaccines, Journal Year: 2025, Volume and Issue: 13(5), P. 484 - 484
Published: April 30, 2025
Background: The national rollout of a vaccine is complex and significant undertaking, made more challenging when the health system experiencing shock, such as in pandemic. Tanzania had relative success its COVID-19 vaccination compared to other African countries. Objectives: To better understand factors that contributed this success, we examined role coordination (one six immunization building blocks) on outcomes rollout. Methods: We obtained qualitative information from published literature, program documents for Mainland Zanzibar, reports two documentation workshops with national, regional, district stakeholders government, partners, academia, civil society. Triangulating information, describe structure, roles responsibilities members, changes their engagement activities over 18 months following introduction vaccine. also quantitative data CHANJOCOVID analyze time trends coverage rates period August 2021 December 2022. Results: found multi-level, multi-partner integrated mechanism provided strategic direction, oversight, guidance structure was initially weak but strengthened time. Based level undertaken, identified three periods marking different strengths mechanisms, these corresponded mainland. In first (July–December 2021), weak, low, only 3% target population vaccinated second (January–May 2022), stakeholder expanded improved, there concurrent rise 4% 25%. third (June–December further strengthened, strategies were intensified; corresponding increase uptake observed reaching 100% population. Conclusions: Qualitative insights suggest positive association between strength coverage. Coordination fostered collaboration, enhanced engagement, facilitated data-driven decision making. This enabled overcome challenges achieve progress Strong effective collaboration among are essential mechanisms processes optimize delivery resources ensure equitable distribution vaccines Tanzania.
Language: Английский
Citations
0
JAIDS Journal of Acquired Immune Deficiency Syndromes, Journal Year: 2024, Volume and Issue: 96(2), P. 106 - 113
Published: April 3, 2024
Background: The COVID-19 pandemic disrupted global economic and healthcare systems. People living with HIV (PLWH) represent a marginalized stigmatized population who may have been particularly impacted. purpose of this analysis was to describe the impact on PLWH in United States. Setting: Methods: We analyzed surveys behavioral clinical characteristics residing 5 states that participated Medical Monitoring Project between 2020 2022. described illness, testing, diagnoses; receipt medical care; social service access; employment; preventive measures by project site demographic characteristics. Results: Unweighted data from 1715 were analyzed. A high proportion had care pandemic; 31% missed appointments, 26% routine laboratory test results, 7% antiretroviral therapy doses. In total, 30% reported losing wages 19% difficulty accessing services. Overall, 88% receiving at least 1 dose vaccine, but vaccine uptake low among younger, Black, Hispanic or Latina/o/x PLWH. Conclusions: This descriptive reinforces previous findings show negatively impacted their ability obtain care. Additional efforts will be critical ameliorating longer-term impacts health supporting through future pandemics system disruptions.
Language: Английский
Citations
3
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: July 13, 2023
Abstract Background The emergence of Omicron variants coincided with declining vaccine-induced protection against SARS-CoV-2 infection and other COVID-19-related outcomes. Two bivalent mRNA vaccines, mRNA-1273.222 (Moderna) BNT162b2 Bivalent (Pfizer-BioNTech) were developed to provide greater the predominate circulating by including that encodes both ancestral (original) strain BA.4/BA.5. We estimated their relative vaccine effectiveness (rVE) in preventing outcomes US. Methods conducted a retrospective cohort study using US nationwide dataset linking primary care electronic health records (EHR) pharmacy/medical claims data. adult population (aged ≥18 years) received either or vaccination between August 31, 2022, February 28, 2023. used propensity score weighting based on inverse probability treatment adjust for baseline differences age, sex, race, ethnicity, geographic region, week, status groups. Outcomes evaluated rVE two vaccines hospitalizations (primary outcome) outpatient visits (secondary). weighted groups prior analysis adjusted hazard ratios (HR) multivariable Cox regression models. calculated as (1−HR) × 100. Results 1,034,538 1,670,666 recipients. versus hospitalization was 9.8% (95% confidence interval: 2.6%–16.4%). 5.1% CI: 3.2%–6.9%). When age group, incremental greater. Among adults ≥ 65, 13.5% 5.5%–20.8%) 10.7% (8.2%–13.1%), respectively. Conclusion found compared visits, increased benefits older adults.
Language: Английский
Citations
8
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1766 - 1766
Published: June 19, 2023
Infection persists as one of the leading global causes morbidity and mortality, with particular burden at extremes age in populations who are immunocompromised or suffer chronic co-morbid diseases. By focusing discovery innovation efforts to better understand phenotypic mechanistic differences immune systems diverse vulnerable populations, emerging research precision vaccine development has explored how optimize immunizations across lifespan. Here, we focus on two key elements vaccinology, applied epidemic/pandemic response preparedness, including (a) selecting robust combinations adjuvants antigens, (b) coupling these platforms appropriate formulation systems. In this context, several considerations exist, intended goals immunization (e.g., achieving immunogenicity versus lessening transmission), reducing likelihood adverse reactogenicity, optimizing route administration. Each is accompanied by challenges. On-going vaccinology will expand target arsenal components for protection populations.
Language: Английский
Citations
7
World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(26), P. 4099 - 4119
Published: July 6, 2023
Coronavirus disease 2019 (COVID-19) has several extrapulmonary symptoms. Gastrointestinal (GI) symptoms are among the most frequent clinical manifestations of COVID-19, with severe consequences reported in elderly patients. Furthermore, impact COVID-19 on patients pre-existing digestive diseases still needs to be fully elucidated, particularly older population. This review aimed investigate GI tract, liver, and pancreas individuals without previous diseases, a particular focus elderly, highlighting distinctive characteristics observed this Finally, effectiveness adverse events anti-COVID-19 vaccination disorders peculiarities found discussed.
Language: Английский
Citations
7
Journal of Energy Storage, Journal Year: 2023, Volume and Issue: 72, P. 108212 - 108212
Published: July 7, 2023
Language: Английский
Citations
6