Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Antibiotics, Journal Year: 2023, Volume and Issue: 12(10), P. 1495 - 1495

Published: Sept. 29, 2023

Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by activation digestive enzymes in pancreatic tissue. The main causes AP are cholelithiasis and alcohol abuse; less commonly, it can be drugs, with a prevalence up to 5%. Causal associations between drugs largely based on case reports or series limited evidence. We reviewed available data drug-induced AP, focusing antimicrobial antivirals, discussed current evidence relation classification systems literature. found 51 suspected antiviral AP. most correlation didanosine, protease inhibitors, metronidazole. In addition, other have been described demonstrating positive rechallenge. However, there major differences various classifications available, where same drug being assigned different probability classes. It likely that presence multiple association should serve as basis for conducting prospective randomized controlled trials improve quality

Language: Английский

---

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(12)

Published: Dec. 1, 2023

Abstract The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development pancreatitis is a subject ongoing debate within academic discourse. Establishing causal link between COVID‐19 and may not be fully supported by relying only retrospective studies or case reports. This study examined relationship phenotypes Mendelian randomization (MR) method. identification instrumental variables (single nucleotide polymorphisms) that exhibit robust association with was accomplished through meticulous process rigorous screening procedures. We included chronic (CP) as outcomes in MR analysis, even though no definitive exist CP. A direct genetically predicted risk cannot established. There an over designation cause pancreatitis.

Language: Английский

---

COVID-19, Possible Hepatic Pathways and Alcohol Abuse—What Do We Know up to 2023?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2212 - 2212

Published: Feb. 12, 2024

The pandemic period due to coronavirus disease 2019 (COVID-19) revolutionized all possible areas of global health. Significant consequences were also related diverse extrapulmonary manifestations this pathology. liver was found be a relatively common organ, beyond the respiratory tract, affected by severe acute syndrome coronavirus-2 (SARS-CoV-2). Multiple studies revealed essential role chronic (CLD) in general outcome infection. Present concerns field are direct hepatic caused COVID-19 and pre-existing disorders as risk factors for course Which mechanism has key phenomenon—previously existing disorder or failure SARS-CoV-2—is still not fully clarified. Alcoholic (ALD) constitutes another elucidated context Should toxic effects ethanol already developed cirrhosis its perceived causative triggering factor impairment patients? In face these discrepancies, we decided summarize whole picture infection, paying special attention ALD focusing on pathological pathways COVID-19, toxicity cirrhosis.

Language: Английский

---

Recent advances in COVID-19-induced liver injury: causes, diagnosis, and management

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2649 - 2680

Published: Aug. 10, 2024

Language: Английский

---

Semi-quantitative CT score reflecting the degree of pulmonary infection as a risk factor of hypokalemia in COVID-19 patients: a cross-sectional study

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 21, 2024

Background Hypokalemia is a common electrolyte disorder observed in patients afflicted with coronavirus disease 2019 (COVID-19). When COVID-19 accompanied by pulmonary infection, chest computed tomography (CT) the preferred diagnostic modality. This study aimed to explore relationship between CT semi-quantitative score reflecting degree of infection and hypokalemia from patients. Methods A single-center, cross-sectional was conducted investigate diagnosed December 2022 January 2023 who underwent scans upon admission revealing typical signs. These were categorized into two groups based on their blood potassium levels: normokalemia group group. Medical history, symptoms, vital signs, laboratory data, severity compared. Binary regression analysis employed identify risk factors associated infection. Results total 288 enrolled study, which 68 (23.6%) had hypokalemia. The found be higher compared [4.0 (3.0–5.0) vs. 3.0 (2.0–4.0), p = 0.001]. result binary logistic revealed that after adjusting for sex, vomiting, sodium, using potassium-excretion diuretics, identified as an independent factor (OR 1.229, 95% CI 1.077–1.403, 0.002). Conclusion In this cohort patients, may serve

Language: Английский

---

Navigating new horizons in inflammatory bowel disease: Integrative approaches and innovations

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(41), P. 4411 - 4416

Published: Oct. 23, 2024

This editorial offers an updated synthesis of the major advancements in management and treatment inflammatory bowel disease (IBD), as documented World Journal Gastroenterology between 2023 early 2024. explores substantial developments across key research areas, such intestinal microecology, computational drug discovery, dual biologic therapy, telemedicine, integration lifestyle changes into patient care. Furthermore, discussion emerging topics, including preparation colonoscopy, impact coronavirus 2019 pandemic, intersection IBD mental health, reflects a shift toward more holistic approach to research. By integrating these diverse areas research, this seeks promote multidisciplinary treatment, combining technologies, personalized medicine, conventional therapies improve outcomes.

Language: Английский

---

Temporal, spatial and demographic distributions characteristics of COVID-19 symptom clusters from chinese medicine perspective: a systematic cross-sectional study in China from 2019 to 2023

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 18, 2024

Language: Английский

---