International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1807 - 1807
Published: Feb. 2, 2024
The
relationship
between
gut
dysbiosis
and
body
mass
index
(BMI)
in
non-diabetic
patients
with
non-alcoholic
fatty
liver
disease
(NAFLD)
is
not
adequately
characterized.
This
study
aimed
to
assess
microbiota's
signature
individuals
NAFLD
stratified
by
BMI.
16S
ribosomal
RNA
sequencing
was
performed
for
microbiota
composition
100
16
healthy
individuals.
differential
abundance
of
bacterial
groups
analyzed
using
the
DESeq2
method.
alpha
diversity
(Chao1,
Shannon,
observed
feature)
beta
significantly
differed
controls.
However,
significant
differences
their
diversities
were
among
subgroups
NAFLD.
At
phylum
level,
there
no
trend
an
elevated
Clinical and Molecular Hepatology,
Journal Year:
2022,
Volume and Issue:
29(Suppl), P. S17 - S31
Published: Nov. 29, 2022
“Metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)”
is
the
term
suggested
in
2020
to
refer
related
systemic
metabolic
dysregulation.
The
name
change
from
nonalcoholic
(NAFLD)
MAFLD
comes
with
a
simple
set
of
criteria
enable
easy
diagnosis
at
bedside
for
general
medical
community,
including
primary
care
physicians.
Since
introduction
term,
there
have
been
key
areas
which
superiority
over
traditional
NAFLD
terminology
has
demonstrated,
risk
and
extrahepatic
mortality,
associations,
identifying
high-risk
individuals.
Additionally,
adopted
by
number
leading
pan-national
national
societies
due
its
concise
diagnostic
criterion,
removal
requirement
exclude
concomitant
diseases,
reduction
stigma
associated
this
condition.
current
article
explores
differences
between
diagnosis,
benefit,
some
potential
limitations,
how
opened
up
new
fields
research.
Liver International,
Journal Year:
2023,
Volume and Issue:
43(11), P. 2425 - 2433
Published: Aug. 17, 2023
The
aim
of
the
present
study
is
to
explore
epidemiologic
impact
definition
steatotic
liver
disease
(SLD)
proposed
by
a
multi-society
(American
Association
for
Study
Liver-the
European
Liver
Diseases-Asociación
Latinoamericana
para
el
Estudio
del
Hígado)
Delphi
consensus
statement.This
cross-sectional
US
adults
participating
in
2017-2020
cycles
National
Health
and
Nutrition
Examination
Survey
who
were
evaluated
vibration-controlled
transient
elastography.
Hepatic
steatosis
fibrosis
diagnosed
median
value
controlled
attenuation
parameter
stiffness
measurement
using
cut-offs
274
dB/m
8.0
kPa,
respectively.
Recently
criteria
metabolic
dysfunction-associated
(MASLD),
MetALD
(MASLD
+
significant
alcohol
consumption),
MASLD-Viral
hepatitis
cryptogenic
SLD
applied.SLD
was
42.1%
(95%
CI:
40.3-43.9)
3173
included
participants.
Among
patients
with
SLD,
99.4%
met
dysfunction
definition.
Moreover,
89.4%,
7.7%,
2.4%,
0.4%
0.1%
defined
as
MASLD,
MetALD,
MASLD-Viral,
alcoholic
(ALD)
(significant
consumption
without
dysfunction)
cryptogenic,
No
had
fibrosis,
which
15.2%,
9.5%
19.5%
MASLD-viral,
Approximately,
90%
overall
adult
population
could
be
according
criteria.
A
high
degree
concordance
found
between
MASLD
previously
fatty
definition.Metabolic
almost
all
United
States.
new
change
diagnostic
did
not
significantly
prevalence.
Experimental Gerontology,
Journal Year:
2023,
Volume and Issue:
174, P. 112121 - 112121
Published: Feb. 17, 2023
The
current
pandemic
of
obesity
represents
a
major
global
public
health
problem,
mainly
due
to
its
association
with
chronic
non-communicable
disabling
conditions
and
increased
mortality.
Population
aging
increases
the
chances
diseases
allowing
longer
exposure
risk
factors
for
these
conditions.
Obesity
is
factor
contributing
pathological
aging.
Numerous
epidemiological
studies
have
shown
that
death
cardiovascular
disease
cancer
progressively
as
overweight
rise.
Nutrition
research
now
focused
on
effects
combinations
foods
in
dietary
patterns
instead
those
single
nutrients
or
foods.
model
largest
body
evidence
benefit
traditionally
followed
by
inhabitants
some
Mediterranean
countries.
There
confirming
inverse
adhering
diet
obesity.
Four
meta-analyses
randomized
controlled
trials,
including
up
16
greater
reduction
weight
BMI
MedDiet
compared
other
diets,
while
meta-analysis
7
prospective
cohort
studies,
found
reduced
becoming
obese
gaining
over
time
associated
higher
adherence
MedDiet.
This
narrative
review
examines
reporting
associations
overweight/obesity
age-associated
related
Clinical and Molecular Hepatology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 19, 2024
As
the
rates
of
obesity
and
type
2
diabetes
(T2D)
continue
to
increase
globally,
so
does
prevalence
metabolic
dysfunction
associated
steatotic
liver
disease
(MASLD).
Currently,
38%
all
adults
7-14%
children
adolescents
have
MASLD.
By
2040,
MASLD
rate
for
is
projected
over
55%.
Although
many
with
will
not
develop
progressive
disease,
given
vast
number
patients
MASLD,
it
has
now
become
top
indication
transplant
in
United
States
those
hepatocellular
carcinoma
(HCC)
women.
However,
most
common
cause
mortality
among
remains
death
cardiovascular
diseases.
In
addition
outcomes
(cirrhosis
HCC),
increased
risk
developing
de-novo
T2D,
chronic
kidney
sarcopenia
extrahepatic
cancers.
Furthermore,
decreased
health
related
quality
life,
work
productivity,
fatigue
healthcare
resource
utilization
substantial
economic
burden.
Similar
other
lifestyle
interventions
heathy
diet
physical
activity
remain
cornerstone
managing
these
patients.
a
T2D
drugs
are
available
treat
co-morbid
Resmetirom
only
MASH-targeted
medication
that
was
recently
approved
by
Federal
Drug
Administration
use
stage
2-3
fibrosis.
The
following
review
provides
an
overview
epidemiology,
its
factors
demonstrates
without
further
global
initiatives,
may
increase.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(1), P. 278 - 278
Published: Jan. 3, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
affects
more
than
30%
of
the
world’s
adult
population.
While
it
is
associated
with
obesity
and
metabolic
syndrome,
emerging
evidence
has
shown
that
a
substantial
number
MASLD
patients
have
normal
body
mass
index
(“lean
individuals
MASLD”).
In
this
article,
we
provide
an
overview
definition,
epidemiology,
pathogenesis,
clinical
outcomes
lean
updates
on
current
management.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Feb. 4, 2025
Abstract
As
a
highly
complex
organ
with
digestive,
endocrine,
and
immune-regulatory
functions,
the
liver
is
pivotal
in
maintaining
physiological
homeostasis
through
its
roles
metabolism,
detoxification,
immune
response.
Various
factors
including
viruses,
alcohol,
metabolites,
toxins,
other
pathogenic
agents
can
compromise
function,
leading
to
acute
or
chronic
injury
that
may
progress
end-stage
diseases.
While
sharing
common
features,
diseases
exhibit
distinct
pathophysiological,
clinical,
therapeutic
profiles.
Currently,
contribute
approximately
2
million
deaths
globally
each
year,
imposing
significant
economic
social
burdens
worldwide.
However,
there
no
cure
for
many
kinds
of
diseases,
partly
due
lack
thorough
understanding
development
these
Therefore,
this
review
provides
comprehensive
examination
epidemiology
characteristics
covering
spectrum
from
conditions
manifestations.
We
also
highlight
multifaceted
mechanisms
underlying
initiation
progression
spanning
molecular
cellular
levels
networks.
Additionally,
offers
updates
on
innovative
diagnostic
techniques,
current
treatments,
potential
targets
presently
under
clinical
evaluation.
Recent
advances
pathogenesis
hold
critical
implications
translational
value
novel
strategies.
