Fibrosis: from mechanisms to medicines

Nature, Journal Year: 2020, Volume and Issue: 587(7835), P. 555 - 566

Published: Nov. 25, 2020

Language: Английский

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mTOR signalling and cellular metabolism are mutual determinants in cancer

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(12), P. 744 - 757

Published: Nov. 13, 2018

Language: Английский

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Metabolic regulation of cell growth and proliferation

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(7), P. 436 - 450

Published: April 11, 2019

Language: Английский

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Lipid metabolism reprogramming and its potential targets in cancer

Cancer Communications, Journal Year: 2018, Volume and Issue: 38(1), P. 1 - 14

Published: May 21, 2018

Abstract Reprogramming of lipid metabolism is a newly recognized hallmark malignancy. Increased uptake, storage and lipogenesis occur in variety cancers contribute to rapid tumor growth. Lipids constitute the basic structure membranes also function as signaling molecules energy sources. Sterol regulatory element‐binding proteins (SREBPs), family membrane‐bound transcription factors endoplasmic reticulum, play central role regulation metabolism. Recent studies have revealed that SREBPs are highly up‐regulated various promote SREBP cleavage‐activating protein key transporter trafficking activation well critical glucose sensor, thus linking de novo synthesis. Targeting altered metabolic pathways has become promising anti‐cancer strategy. This review summarizes recent progress our understanding malignancy, highlights potential molecular targets their inhibitors for cancer treatment.

Language: Английский

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Metabolomics in cancer research and emerging applications in clinical oncology

CA A Cancer Journal for Clinicians, Journal Year: 2021, Volume and Issue: 71(4), P. 333 - 358

Published: May 13, 2021

Abstract Cancer has myriad effects on metabolism that include both rewiring of intracellular to enable cancer cells proliferate inappropriately and adapt the tumor microenvironment, changes in normal tissue metabolism. With recognition fluorodeoxyglucose‐positron emission tomography imaging is an important tool for management many cancers, other metabolites biological samples have been spotlight diagnosis, monitoring, therapy. Metabolomics global analysis small molecule like ‐omics technologies can provide critical information about state are otherwise not apparent. Here, authors review how therapies interact with at cellular systemic levels. An overview metabolomics provided a focus currently available they applied clinical translational research setting. The also discuss could be further leveraged future improve patients cancer.

Language: Английский

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Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(1), P. 21 - 32

Published: Jan. 4, 2021

Language: Английский

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Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy

Cell, Journal Year: 2020, Volume and Issue: 183(5), P. 1436 - 1456.e31

Published: Nov. 1, 2020

The integration of mass spectrometry-based proteomics with next-generation DNA and RNA sequencing profiles tumors more comprehensively. Here this "proteogenomics" approach was applied to 122 treatment-naive primary breast cancers accrued preserve post-translational modifications, including protein phosphorylation acetylation. Proteogenomics challenged standard cancer diagnoses, provided detailed analysis the ERBB2 amplicon, defined tumor subsets that could benefit from immune checkpoint therapy, allowed accurate assessment Rb status for prediction CDK4/6 inhibitor responsiveness. Phosphoproteomics uncovered novel associations between suppressor loss targetable kinases. Acetylproteome highlighted acetylation on key nuclear proteins involved in damage response revealed cross-talk cytoplasmic mitochondrial metabolism. Our results underscore potential proteogenomics clinical investigation through annotation pathways biological features remarkably heterogeneous malignancy.

Language: Английский

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Cuproptosis: mechanisms and links with cancers

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 7, 2023

Abstract Cuproptosis was a copper-dependent and unique kind of cell death that separate from existing other forms death. The last decade has witnessed considerable increase in investigations programmed death, whether copper induced an independent form long been argued until mechanism cuproptosis revealed. After that, increasing number researchers attempted to identify the relationship between process cancer. Thus, this review, we systematically detailed systemic cellular metabolic processes copper-related tumor signaling pathways. Moreover, not only focus on discovery its mechanism, but also outline association cancers. Finally, further highlight possible therapeutic direction employing ion ionophores with cuproptosis-inducing functions combination small molecule drugs for targeted therapy treat specific

Language: Английский

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Targeting immunometabolism as an anti-inflammatory strategy

Cell Research, Journal Year: 2020, Volume and Issue: 30(4), P. 300 - 314

Published: March 4, 2020

Abstract The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP biosynthetic precursors, but are also way controlling immunity inflammation. Metabolic reprogramming immune cells is essential for both inflammatory as well anti-inflammatory responses. Four therapies, DMF, Metformin, Methotrexate Rapamycin all work by affecting metabolism and/or regulating or mimicking endogenous metabolites with effects. Evidence emerging the targeting specific events strategy limit inflammation in different contexts. Here we discuss these recent developments speculate on prospect effort develop novel therapeutics. As accumulating evidence roles an intricate elaborate network processes, including lipid, amino acid nucleotide provides key focal points developing new here turn our attention glycolysis TCA cycle examples intermediates enzymes can potential therapeutic targets.

Language: Английский

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Improving the metabolic fidelity of cancer models with a physiological cell culture medium

Science Advances, Journal Year: 2019, Volume and Issue: 5(1)

Published: Jan. 3, 2019

Plasmax, a physiological cell culture medium, prevents metabolic artifacts imposed on cancer cells by commonly used media.

Language: Английский

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