Toxic effects of prolonged propofol exposure on cardiac development in zebrafish larvae

BMC Anesthesiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 18, 2025

Propofol, commonly used as an intravenous anesthetic during pregnancy, can easily penetrate the placental barrier, potentially affecting fetal heart development. This study aims to investigate propofol's impact on developing zebrafish structure and function, identify potential drug targets. Zebrafish embryos were exposed different concentrations of propofol (0.5, 1, 5 mg/L) observe changes in larval function (heart rate). In vitro cell experiments conducted assess effects at cardiomyocyte viability migration. Transcriptomic sequencing was utilized validate targets associated with propofol-induced cardiac toxicity. The results demonstrate that dose-dependently reduces hatching survival rates larvae, while increasing rate deformities. Transgenic green fluorescent larvae exhibit enlarged cavities, HE staining reveals thinning myocardial wall. Additionally, propofol-treated show a decrease rate. We also showing decreased viability, reduced migration increased apoptosis. Finally, transcriptome analysis differential gene co-expression network agxt2 target conclusion, our indicates alters heart, mitochondrial-related possibly being its pharmacological effects.

Language: Английский

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Environmental impact of anesthetic drugs

Current Opinion in Anaesthesiology, Journal Year: 2024, Volume and Issue: 37(4), P. 379 - 383

Published: June 4, 2024

Purpose of review The environmental impact anesthesia far exceeds that other medical specialties due to our use inhaled anesthetic agents (which are potent greenhouse gases) and many intravenous medications. Recent findings Calls for reducing the carbon footprint ubiquitous in societies developed nations appearing proposed changes hospital accreditation funding United States. body research on atmospheric, land water impacts pharmaceuticals is growing generally reinforces existing recommendations reduce gas emissions care. Summary care should factor into clinical decisions. onus clinicians safely patients ways contribute least harm environment. Intravenous regional techniques have less than agents; efforts properly dispose pharmaceutical waste central burden; desflurane not be used; nitrous oxide avoided except where clinically necessary; pipelines abandoned; low fresh flows utilized whenever used.

Language: Английский

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Environmental impact of propofol: A critical review of ecotoxicity and greenhouse effects

Best Practice & Research Clinical Anaesthesiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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ADB-FUBINACA-induced developmental toxicity, neurotoxicity, and cardiotoxicity in embryonic zebrafish (Danio rerio)

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121517 - 121517

Published: April 1, 2025

Language: Английский

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The effects of Myo-inositol on antioxidant capacity and immunity in freshwater crayfish

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(4)

Published: April 3, 2025

Language: Английский

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Ecological assessment of stream water polluted by phosphorus chemical plant: Physiological, biochemical, and molecular effects on zebrafish (Danio rerio) embryos

Environmental Research, Journal Year: 2024, Volume and Issue: 247, P. 118173 - 118173

Published: Jan. 14, 2024

Language: Английский

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Accumulation and elimination properties and comparative toxicity of fluxapyroxad in juvenile and adult large yellow croaker (Larimichthys crocea)

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 168979 - 168979

Published: Nov. 28, 2023

Language: Английский

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Alleviation of bovine serum albumin on the neurotoxicity of silver nanoparticles in zebrafish (Danio rerio) larvae

Frontiers in Marine Science, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 19, 2024

Silver nanoparticles (AgNPs) are ubiquitous in the aquatic environment and have attracted extensive attention to their toxic effects on species. However, responses of nervous system AgNPs little known, especially co-existing with natural organic matter (NOM), which is critical for ability act Here, this study investigated neurotoxicology environmentally relevant or without bovine serum albumin (BSA; a classical NOM) zebrafish ( Danio rerio ) using visualized transgenic zebrafish. Exposure reduced locomotor behavior by 28%–45%, including swimming distance velocity, exhibiting obvious behavioral inhibition. The treated showed developmental retardation early development heart, central nervous, motor nerve, as well related neurodevelopment genes, may be responsible lowered behavior. In addition, can specifically interfere cholinergic affect neuronal signaling, ultimately leading abnormalities. BSA alleviated neurotoxicity zebrafish, partially attributed increased size electronegativity caused BSA, thus reducing direct interaction cells. between released Ag + from also alleviation dysfunction These findings provide valuable insights into toxicity risks environments.

Language: Английский

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Environmentally Relevant Concentrations of Propofol-Induced Metabolic Dysfunction in Zebrafish: Mechanistic Insights into Integrated Hepatic Transcriptomic and Metabolomic Analyses

ACS ES&T Water, Journal Year: 2024, Volume and Issue: 4(5), P. 2192 - 2203

Published: April 12, 2024

Propofol is increasingly perceived as an emerging threat to aquatic ecosystems, although the ecotoxicity and underlying mechanisms of propofol on life have not yet been clearly established. In this study, zebrafish (Danio rerio) was exposed different concentrations (0.008, 0.04, 0.2 mg·L–1) probe effect functional metabolism ecological response mechanism in organisms. induced severe hepatic damage, including increased interstitial spaces nuclear malformations at tissue level. Reactive oxygen species (ROS) production lipid peroxidation were after 28 days exposure, while activities aspartate aminotransferase (AST) alanine (ALT) substantially increased, suggesting that may influence injury through exacerbating oxidative damage. Exacerbated levels triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) indicative dysregulated metabolism. Comprehensive transcriptomics metabolomics analyses showed mainly changed glycerophospholipid metabolism, citric acid cycle, purine disorders these pathways can aggravate accumulation Overall, study revealed hepatotoxicity metabolic dysfunction zebrafish, providing constructive insights for a comprehensive assessment toxicity risk posed by environmental health.

Language: Английский

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Insight into Tryptophan-Dependent Interaction Mechanisms between Peptides and Anthocyanins for Stability Enhancement

ACS Food Science & Technology, Journal Year: 2023, Volume and Issue: 3(12), P. 2065 - 2077

Published: Nov. 10, 2023

Anthocyanin degradation from alkaline or heat exposure limits its practical applications. Peptide-based microencapsulation can enhance anthocyanin's physicochemical properties, such as pH and temperature stability. However, the diversity of amino acids makes investigating complex interactions between peptides anthocyanins experimentally challenging. In this study, we engineered four amphiphilic α helix (C6W1, C6W2, C6W4, C6W6) with varying tryptophan contents (one, two, four, six) to explore tryptophan-dependent interaction mechanisms for improved anthocyanin Molecular docking molecular dynamics simulations showed that higher content exhibit stronger anthocyanins, evidenced by electrostatic forces, Lennard-Jones interactions, Gibbs free energy, hydrogen bonds. Notably, computational data aligns our previous experimental findings on coassembly stability enhancement C6W4) anthocyanins. This research offers valuable guidance peptide design enhanced potentially improving their properties broadening

Language: Английский

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