Multiclass Determination of Endocrine-Disrupting Chemicals in Meconium: First Evidence of Perfluoroalkyl Substances in This Biological Compartment

Toxics, Journal Year: 2024, Volume and Issue: 12(1), P. 75 - 75

Published: Jan. 15, 2024

Major concerns have been raised about human exposure to endocrine-disrupting chemicals (EDCs) during pregnancy. Effective methodologies for the assessment of this are needed support implementation preventive measures and prediction negative health effects. Meconium has proven a valuable non-invasive matrix evaluating cumulative xenobiotics last two trimesters The study objective was develop novel method determine presence in meconium perfluoroalkyl substances (PFASs), bisphenols, parabens, benzophenones, EDCs that widely used manufacture numerous consumer goods personal care products, including cosmetics. Ten PFASs, four benzophenones were measured samples prepared by using combination Captiva Enhanced Matrix Removal (EMR) lipid cartridges with salt-assisted liquid–liquid extraction (SALLE) dispersive microextraction (DLLME) before application liquid chromatography–tandem mass spectrometry (LC–MS/MS). Experimental parameters optimized applying different chemometric techniques. Limits detection ranged from 0.05 0.1 ng g−1, between-day variabilities (relative standard deviations) 6.5% 14.5%. validated matrix-matched calibration followed recovery assay spiked samples, obtaining percentage recoveries 89.9% 114.8%. then employed measure compounds not previously studied 20 samples. proposed analytical procedure yields information on utero selected EDCs.

Language: Английский

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Flavonoid‐based yellow dye extract from safflower (Carthamus tinctorius L.) combined with chitosan for anti‐bacterial and ultraviolet‐protective functionalisation of silk

Coloration Technology, Journal Year: 2024, Volume and Issue: 140(6), P. 900 - 912

Published: Feb. 11, 2024

Abstract In the modern period, scientists are interested in functional properties of natural materials. The present study is first report on use safflower ( Carthamus tinctorius L.) yellow dye extract combined with chitosan bio‐mordant for enhancing anti‐bacterial and ultraviolet‐protective activities silk. presence flavonoid‐based compounds was verified using liquid chromatography–mass spectrometry, Fourier transform‐infrared spectroscopy, ultraviolet‐visible techniques. Moreover, alum mordant also utilised silk dyeing process to compare efficiency bio metallic mordanting agents. Experiment outcomes revealed that mordanted‐dyed sustained adequate fastness after being tested by washing, light, wet‐rubbing, dry‐rubbing. addition, superb bacterial inhibition percentages 89% 76% against Escherichia coli Staphylococcus aureus , individually, were accomplished. Furthermore, behaviour this sample demonstrated a 50+ ultraviolet protection factor low‐grade transmittance. This reveals great performance an organic flavonoid as sustainable environmentally‐friendly substance functionalising silk, well efficacy green over increasing dyeability

Language: Английский

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The Impact of Organic Micropollutants on the Biochemical Composition and Stress Markers in Wolffia arrhiza

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 445 - 445

Published: Jan. 21, 2025

For many years, there has been a growing pollution of the aquatic environment with personal care products and industrial chemicals, main source which is municipal wastewater. This raises need to assess impact these pollutants on ecosystems, including plants living in environment. It important develop methods for their removal from wastewater, among using phytoremediation promising solution. study aimed evaluate response plant Wolffia arrhiza (Lemnaceae) low concentrations bisphenol A (BPA), N,N-diethyl-m-toluamide (DEET), triclosan (TRC), benzophenone (BPH), endosulfan alpha (α-END), beta (β-END). The growth, content cellular components, oxidative stress markers were assessed contact single compounds at 0.1 mg/L 1 mg/L, mixture total concentration mg/L. All used inhibited W. growth stimulated degradation proteins but enhanced level saccharides. TRC, BPH, α-END, β-END had negative photosynthetic pigments. Increased MDA H2O2 registered exposed BPA, β-END. higher toxic effects than individual substances.

Language: Английский

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Exposure Profiles, Determinants, and Health Risks of Chemicals in Personal Care Products Among Healthy Older Adults from the China BAPE Study

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137365 - 137365

Published: Jan. 25, 2025

Language: Английский

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Pattern Recognition-Driven Detection of Circadian-Disruptive Compounds from Gene Expressions: High-Throughput Screening and Experimental Verification

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Circadian rhythms regulate the timing of numerous biological functions in organisms. Besides well-known external stimuli like light–dark cycle and temperature, circadian can also be modulated by environmental substances. However, this area remains largely underexplored. Here, we developed a robust Pattern Recognition-Driven Prediction Approach (PRD–PA) that enables identification circadian-disruptive compounds from large-scale zebrafish transcriptomic profiling. The approach utilizes gene panel consisting over 270 Circadian-Indicating Genes (CIGs) with stable periodicity combines it predictive model, known as Differential Gene Expression Values an Individual Comparison Model (DGVICM), effectively predict internal phases samples. By analyzing 692 aggregated expression profiles across 40 substances, several were identified having significant potential. These include glucocorticoids (e.g., prednisone (PRE) triamcinolone (TRI)), antithyroid agent propylthiouracil (PTU), widely used UV filter benzophenone-3 (BP-3). Both PTU are well-documented disruptors rhythms, BP-3's circadian-disrupting properties validated through experimental exposures. Moreover, BP-3 analogs, including 2,4-dihydroxybenzophenone (BP-1) 2,2'-dihydroxy-4-methoxybenzophenone (BP-8), found to exhibit similar effects. Overall, present findings demonstrated reliability PRD–PA for disruption screening highlighted presence diverse substances our environment.

Language: Английский

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Safety of new food contact materials: Migration and sorption studies based on Tenax, powdered milk, baby cereal and oat flakes

Food Chemistry, Journal Year: 2025, Volume and Issue: 483, P. 144148 - 144148

Published: April 6, 2025

Language: Английский

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Analysis of potential human accumulation differences and mechanisms of environmental new flame retardants: Based on in vitro experiments and theoretical calculations

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 963, P. 178542 - 178542

Published: Jan. 17, 2025

Language: Английский

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Biotransformation of oxybenzone and 3-(4-methylbenzylidene)camphor in Cunninghamella species: potential for environmental clean-up of widely used sunscreen agents

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137544 - 137544

Published: Feb. 11, 2025

Language: Английский

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Covalent Organic Framework Nanofilm‐Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products

Rapid Communications in Mass Spectrometry, Journal Year: 2025, Volume and Issue: 39(10)

Published: Feb. 14, 2025

ABSTRACT Rational Benzophenone derivatives, commonly used as UV filters in personal care products (PCPs), are widely prevalent and raise concerns due to their endocrine‐disrupting effects. Sensitive efficient analytical methods demand for detection. In this study, we developed a TAPB‐DMTP‐covalent organic framework (COF) nanofilm‐assisted laser desorption ionization mass spectrometry (LDI‐MS) method the quantitative analysis of 2,4‐dihydroxybenzophenone (BP‐1) PCPs. Methods The TAPB‐DMTP‐COF nanofilm was synthesized on indium tin oxide (ITO) glass utilized an LDI‐MS substrate. performance analyzing small molecules (e.g., benzophenone phthalates, amino acids, sugars, nucleosides) compared conventional matrices (α‐cyano‐4‐hydroxycinnamic acid [CHCA], 2,5‐dihydroxybenzoic [DHB], sinapinic [SA]). reproducibility, salt resistance, sensitivity, stability were further evaluated. Finally, technique applied quantify BP‐1 Results provided stronger spectral signals cleaner backgrounds CHCA, DHB, SA. exhibited high reproducibility (RSD = 6.10%) up 30 days. PCPs quantified with excellent linearity (1–20 μg/mL, r 0.9993), low detection limit (0.3 μg/mL), recovery rates 94.2%–104.4%, demonstrating potential sensitive reliable small‐molecule analysis. Conclusion offered advantages rapid analysis, clean backgrounds, detecting molecules, including derivatives. This successfully PCPs, highlighting its suitability complex samples.

Language: Английский

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Exposure of individuals aged 18–44 years to personal care products in Beijing, China: Exposure profiles, possible influencing factors, and risk assessment

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 148, P. 691 - 701

Published: Feb. 10, 2024

Language: Английский

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