Uncovering layer by layer the risk of nanoplastics to the environment and human health DOI
Joana Antunes, Paula Sobral, Vasco Branco

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2024, Volume and Issue: 28(2), P. 63 - 121

Published: Dec. 13, 2024

Nanoplastics (NPs), defined as plastic particles with dimensions less than 100 nm, have emerged a persistent environmental contaminant potential risk to both environment and human health. might translocate across biological barriers accumulate in vital organs, leading inflammatory responses, oxidative stress, genotoxicity, already reported several organisms. Disruptions cellular functions, hormonal balance, immune responses were also linked NPs exposure vitro assays. Further, been found adsorb other pollutants, such organic pollutants (POPs), leach additives potentially amplifying their advere impacts, increasing the threat organisms greater alone. However, toxic effects remain largely unexplored, requiring further research elucidate risks health, especially accumulation, degradation, migration, interactions systems long-term consequences of chronic these compounds. This review provides an overview current state-of-art regarding mechanisms toxicity within cells.

Language: Английский

Long-term polystyrene nanoplastic exposure disrupt hepatic lipid metabolism and cause atherosclerosis in ApoE-/- mice DOI
Jing Wen, Hang Sun, Bingwei Yang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 466, P. 133583 - 133583

Published: Jan. 22, 2024

Language: Английский

Citations

17
Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: Insights from in vivo and in vitro studies DOI

Reza Nozari asl,

N. Jaafarzadeh, Faezeh Jahedi

et al.

Annales de Toxicologie Analytique, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

3
Microplastics exposure promotes the proliferation of skin cancer cells but inhibits the growth of normal skin cells by regulating the inflammatory process DOI Creative Commons
Yuchen Wang,

Xinqi Xu,

Guan Jiang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 267, P. 115636 - 115636

Published: Nov. 1, 2023

Cutaneous squamous cell carcinoma (CSCC) is one of the most common malignant tumors skin, occurring primarily in elderly population. CSCC second nonmelanoma skin malignancy humans. The development cutaneous closely linked to environmental factors. Microplastics, as a new pollutant, are currently being intensively studied for their potential health effects. However, effect microplastics on cancer not yet known and an important scientific question that needs be addressed. To this end, current study, two lines (SCL-1 A431) were utilized investigate effects cancer, behavior experiments showed internalized into line time- dose-dependent manner. Further promoted proliferation cells by MTT, flow cytometry, laser confocal microscopy, Western blotting other experimental techniques. Mechanistic studies could lead increased mitochondrial ROS cells, which turn caused change membrane potential, thus opening mPTP, release mt-DNA from mitochondria cytoplasm, activating NLRP3 ultimately causing proliferation. We further evaluated HaCaT normal model damage through NLRP3-mediated inflammation scorch death. study suggests microplastics, contaminant, may promote tumor while skin.

Language: Английский

Citations

34
A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis DOI
R. K. Gautam,

Laltanpuia,

Nishant Singh

et al.

Inhalation Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 11, 2025

In the past decade, microplastics (MPs) have drawn significant attention as widespread environmental contaminants, with research increasingly highlighting their harmful effects on respiratory health in aquatic and terrestrial organisms. Findings revealed human lung tissues, raising concerns about potential role damaging tissue integrity contributing to pulmonary fibrosis-a chronic inflammatory condition characterized by scarring of epithelial tissues due accumulated extracellular matrix, triggered factors such alcohol, pathogens, genetic mutations, pollutants. this review, we explore both well-studied lesser-studied mechanisms signaling pathways, aiming shed light how might act mediators that activate distinct, often overlooked cascades. This review searched PubMed Google Scholar using keywords like "plastic," "microplastic," "lung fibrosis," "pulmonary system," "exposure route," "signaling pathways," combined "OR" "AND" singular plural forms. These pathways could not only induce damage but also play a development fibrosis. be targeted reduce microplastic-induced fibrosis, opening new avenues for future treatments.

Language: Английский

Citations

1
Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review DOI Open Access

Eliasz Dzierżyński,

Piotr Gawlik, Damian Puźniak

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703

Published: Nov. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Language: Английский

Citations

7
Predictive metabolomic signatures for safety assessment of three plastic nanoparticles using intestinal organoids DOI
Lihui Xuan, Jinhua Luo,

Can Qu

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 913, P. 169606 - 169606

Published: Dec. 28, 2023

Language: Английский

Citations

15
Nasal instillation of polystyrene nanoplastics induce lung injury via mitochondrial DNA release and activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-signaling cascade DOI
Jing Liu, Fang Xu,

Mingzhu Guo

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174674 - 174674

Published: July 11, 2024

Language: Английский

Citations

5
Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion DOI Creative Commons
Lu Wang, Jiaqi Ma,

Li-Jia Song

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117711 - 117711

Published: Jan. 1, 2025

Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis internal environment in patients with chronic diseases. The effects NP contamination on health chronically ill populations must urgently be elucidated. In this study, NPs injected via tail vein were distributed brain and organs mouse model carotid occlusion. Mice artery occlusion exposed showed behavioral abnormalities, such as depression anxiety, thus indicating detrimental brain. Subsequently, we used proteomics metabolomics analyze specific mechanisms underlying damaging deposition findings helped explain differences biochemical responses at microscopic level mice after exposure. not only accumulated caused pathologic damage, but also contributed accelerating atherosclerosis This work confirms risk elucidates mechanism harm; moreover, it provides theoretical support for developing strategies decrease microplastic intake

Language: Английский

Citations

0
Biological Effects of Micro-/Nano-Plastics in Macrophages DOI Creative Commons
Massimiliano G. Bianchi, Lavinia Casati,

Giulia Sauro

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 394 - 394

Published: March 4, 2025

The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence micro- (MPs) and nanosized (NPs) plastic particles. MPs NPs are thus widely present in water air inevitably enter food chain, with inhalation ingestion as main exposure routes for humans. Many recent studies have demonstrated that gain access several body compartments, where they taken up cells, increase production reactive oxygen species, lead inflammatory changes. In most tissues, resident macrophages engage first approach foreign materials, this interaction largely affects subsequent fate material possible pathological outcomes. On other hand, organizers controllers both responses tissue repair. Here, we aim summarize available information on NPs. Particular attention will be devoted consequences macrophage viability functions, well implications pathology.

Language: Английский

Citations

0
Environmental low-dose nanosized carbon black exposure aggravates lung fibrosis-induced by radiation in vivo and in vitro DOI

Can Qu,

Chenjun Bai,

Jinhua Luo

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 972, P. 179119 - 179119

Published: March 15, 2025

Language: Английский

Citations

0