Screening and regulatory mechanism exploration of M1 macrophage polarization and efferocytosis-related biomarkers in coronary heart disease DOI Creative Commons

Hong Gao,

Junhua Li, Huang Jian-xin

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 5, 2024

Background Macrophage polarization and efferocytosis have been implicated in CHD. However, the underlying mechanisms remain elusive. This study aimed to identify CHD-associated biomarkers using transcriptomic data. Methods examined 74 efferocytosis-related genes (ERGs) 17 M1 macrophage polarization-related (MRGs) across two CHD-relevant datasets, GSE113079 GSE42148. Differential expression analysis was performed separately on each dataset differentially expressed (DEGs1 DEGs2). The intersection of upregulated downregulated from both sets then used define final DEGs. Subsequently, MRG ERG scores were calculated within dataset, followed by weighted gene co-expression network (WGCNA) key module genes. overlap between these DEGs yielded candidate biomarkers, which further evaluated through machine learning, receiver operating characteristic (ROC) curve analysis, profiling. These subsequently leveraged explore immune infiltration patterns construct a molecular regulatory network. To validate their expression, quantitative reverse transcriptase PCR (qRT-PCR) clinical CHD samples, confirming relevance disease. Results A total 93 identified intersecting DEGs1 DEGs2. WGCNA 15,936 dataset. Machine learning ROC highlighted four biomarkers: C5orf58, CTAG1A, ZNF180, IL13RA1. Among these, ZNF180 cases, while CTAG1A IL13RA1 upregulated. qRT-PCR results validated findings for showed inconsistent trends. Immune indicated all had positive correlation with M0 macrophage, negative with. NK cells activated. displayed that GATA2 YY1 could regulate ZNF180. Conclusions suggest serve as linking CHD, providing valuable insights diagnosis therapeutic strategies.

Language: Английский

The interactions and biological pathways among metabolomics products of patients with coronary heart disease DOI Open Access

Chun Chu,

Shengquan Liu,

Liangui Nie

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116305 - 116305

Published: Feb. 29, 2024

Through bioinformatics analysis, this study explores the interactions and biological pathways involving metabolomic products in patients diagnosed with coronary heart disease (CHD).

Language: Английский

Citations

5
The relationship between remnant cholesterol and young-onset myocardial infarction in patients with type 2 diabetes: a retrospective study DOI Creative Commons
Yajie Gao, Lei Tang, Peizhu Dang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Remnant cholesterol (RC) has emerged as a novel therapeutic target beyond low-destiny-lipoproteins (LDL-c). While elevated RC levels are strongly associated with cardiovascular disease risk in the general population, their specific role young-onset acute myocardial infarction (AMI) among patients type 2 diabetes mellitus (T2DM) remains insufficiently explored and warrants further investigation. This retrospective study included AMI T2DM admitted to First Affiliated Hospital of Xi'an Jiaotong University from 2018 2022. Patients were stratified into tertiles according compared using thresholds derived commanded values PREDIMED cohort study. The primary outcome was AMI. Group differences analyzed chi-square test Kruskal-Wallis H test, while Spearman correlation analyses assessed relationships between variables. Univariate multivariate logistic regression employed evaluate association Among 2,514 participants (mean age 61.58 ± 11.15 years), 802 (31.9%) had increase increased significantly rising (27.0% vs 29.7% 39.1%, P < 0.001). showed significant positive total (TC, r = 0.497, 0.001), triglycerides (TG, 0.411, LDL-c (r 0.166, independently higher (OR: 1.579; 95% CI: 1.354-1.842; even after adjusting for other traditional factors 1.415; CI 1.189-1.684; Notably, remained linked regardless whether within desired range. is independent factor patients, irrespective level. These findings underscore importance monitoring managing clinical practice mitigate this population.

Language: Английский

Citations

0
The application and effect evaluation of continuity precision nursing in patients undergoing coronary angiography and stent implantation: A study of clinical outcomes DOI Creative Commons
L Tan,

Xiaojing Tan,

C C Zhang

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(12), P. e41879 - e41879

Published: March 21, 2025

Coronary artery disease is a major global health burden, with percutaneous coronary intervention (PCI) serving as key treatment strategy. Despite its efficacy, challenges such in-stent restenosis, medication nonadherence, unhealthy lifestyles, and psychological distress hinder optimal recovery. Continuity-based precision nursing, which integrates personalized care multidisciplinary support, offers potential solution. Therefore, the purpose of this study to evaluate effectiveness continuity-based nursing compared conventional in improving postoperative outcomes for PCI patients. This includes assessing impact on cardiac function recovery, complication prevention, adherence, lifestyle modifications, well-being, overall quality life. included 112 patients treated from January 2023 2024, divided into an experimental group (continuity-based nursing) control (conventional nursing). Propensity score matching resulted 45 matched pairs. Data collected demographics, function, changes, status, complications, satisfaction, health-related Statistical analyses were performed using SPSS, P < .05 considered significant. showed significant benefits over nursing. At 1 month post-PCI, had higher left ventricular ejection fraction ≥ 50% rates (86.7% vs 75.6%) lower restenosis (6.7% 17.8%) residual stenosis (8.9% 24.4%, = .048). Medication adherence was improved 66.7%, .02), eof smoking cessation (77.8% 55.6%, .01), healthy eating (84.4% .03), regular exercise (80.0% 62.2%, .02). Anxiety depression scores significantly post-intervention. Patient satisfaction (92.5 ± 4.2 85.7 6.1, .01) life (88.4 5.0 81.2 6.0, also markedly higher. enhances patients, behaviors, well-being. model provides comprehensive framework care, broader clinical application. Further research should long-term scalability diverse settings.

Language: Английский

Citations

0
Research progress of regulating intestinal flora by traditional Chinese medicine in treating coronary heart disease DOI Open Access

Qiwen Lu,

Sang Luo,

Chengyan Guan

et al.

Chinese Herbal Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Angiopoietin-like protein Inhibitors: Promising Prospects for the Treatment of Familial Hypercholesterolemia and Atherogenic Dyslipidemia DOI

Fatemeh Vahdat‐Lasemi,

Leila Farhoudi,

Seyedeh Maryam Hosseinikhah

et al.

Atherosclerosis, Journal Year: 2025, Volume and Issue: 405, P. 119235 - 119235

Published: May 2, 2025

Language: Английский

Citations

0
Association between left ventricular remodeling and lipid profiles in obese children: an observational study DOI Creative Commons
Ying Tang, Guangbin Yang, Jun Chen

et al.

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 23, 2024

Objective Childhood obesity has become a prominent issue in the society, which can lead to left ventricular remodeling and severe cardiovascular complications adulthood. It is beneficial identify causes of so that targeted measures be taken prevent disease. Therefore, this study aimed explore relationship between changes blood lipid indexes obese children. Methods This was conducted on 40 healthy non-obese children 140 diagnosed pediatric health department our hospital. Clinical data collected from two groups were compared. Echocardiography performed examine configuration cardiac function. Multiple linear regression analysis assess independent effects levels echocardiographic parameters. Blood indicators among different structural patterns classified according mass relative wall thickness Results Obese exhibited significantly increased height, weight, body index (BMI), fat percentage (BFP), pressure, triglycerides, total cholesterol, internal diameter (LVIDd), interventricular septum (IVSd), posterior diastolic (LVPWd), myocardial (LVM) (RWT), as well lower high-density lipoprotein cholesterol (HDL-C) ejection fraction (LVEF) compared ( P &lt; 0.05). correlation showed LVM had positive with BMI r = 3.21, 0.002) SBP 2.61, 0.01); LVMI negative HDL-C −2.45, 0.015); RWT 2.50, 0.013) but −2.35, 0.02). Furthermore, there significant differences values configurations 0.05), lowest value recorded concentric hypertrophy group. Conclusion will develop remodeling. The are most associated serum HDL-C. Lower level contributes severer hypertrophy, indicating pattern.

Language: Английский

Citations

1
Coronary Heart Disease Risk and Associated Risk Factor Among Workers at PT.X in 2023 DOI Open Access

Jeanita Haldy,

L. Meily Kurniawidjaja

Media Publikasi Promosi Kesehatan Indonesia (MPPKI), Journal Year: 2024, Volume and Issue: 7(6), P. 1636 - 1641

Published: June 3, 2024

Introduction: Coronary heart disease is also a major cause of death and permanent disability among workers. In Indonesia, the estimated loss due to decreased productivity treatment costs for CHD 6.8% GDP per year. The risk in industry increased stress from long working hours, shift work affecting work, eating, sleeping patterns. Objective: To evaluate workers at PT. X, an oil gas company, describe frequency distribution factors Method: research design descriptive analytics with cross-sectional design. Sample data was collected annual health examination X 2023. Framingham score (FRS) used predict incidence rate next 10 years. Result: indicates that man employees comprise 76.2%, age <40 years old 44.9%, 8.8% have hypertension, 2.6% diabetes, 62.1% obese. results prediction calculations using are 0.4% high risk, 15.9% intermediate risk. Risk factor found gender (pvalue = 0,000 ; OR 18,6), 0,000; 54,3), SBP 0,002; 3,2), TC 0,032; 2,1), HDL 0,017; 0,4), fasting blood sugar 6,5), smoking habits 4,8), BMI 0,013; 4,2). Conclusion: predicting coronary over PT.X indicate Gender, age, systolic pressure, total cholesterol, HDL, sugar, habits, body mass index (BMI) significantly associated disease.

Language: Английский

Citations

0
Exploring global research trends in Chinese medicine for atherosclerosis: a bibliometric study 2012–2023 DOI Creative Commons

Moye Tan,

J. Wang,

Zhengxin Chen

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: June 17, 2024

Background While Traditional Chinese Medicine (TCM) boasts an extensive historical lineage and abundant clinical expertise in addressing atherosclerosis, this field is yet to be penetrated adequately by bibliometric studies. This study envisaged evaluate the contemporary scenario of TCM conjunction with atherosclerosis over preceding decade while also identifying forthcoming research trends emerging topics via lens analysis. Methods Literature pertaining circulated between January 1, 2012 November 14, 2023, was garnered for purpose research. The examination embraced annual publications, primary countries/regions, engaged institutions authors, scholarly journals, references, keywords, utilizing analytical tools like Bibliometrix, CiteSpace, ScimagoGraphica, VOSviewer present R package. Result a total 1,623 articles, majority which have been contributed China field, significant contributions stemming from Academy Beijing University Medicine. Moreover, has received financial support both National Natural Science Foundation Key Basic Research Development Program. Wang Yong tops list terms publication count, Xu Hao's articles take lead number citations, positioning them at core authors’ collaborative network. Journal Ethnopharmacology leads most publications greatest citations. Principal foci within intersection Atherosclerosis encompass disease characteristics pathogenic mechanisms, theoretical underpinnings syndrome-specific treatments medicine, potentialities herbal interventions, modulation exerted medicines on gut microbiota. Conclusion analysis offers sweeping survey condition, principal foci, progressive worldwide related atherosclerosis. It further delves into in-depth dissection prominent countries, institutions, scholars that made noteworthy strides discipline. Additionally, report analyzes cited developments, hotspots providing reference future directions researchers practitioners.

Language: Английский

Citations

0
Research Progress of Relationship between Bilirubin Level and Coronary Heart Disease DOI

松林 胡

Asian Case Reports in Emergency Medicine, Journal Year: 2024, Volume and Issue: 12(03), P. 82 - 87

Published: Jan. 1, 2024

Language: Английский

Citations

0
Risk factors associated with the false positive of cardiopulmonary exercise test in the diagnosis of coronary heart disease DOI Creative Commons
Xinwei Wang, Haibo Zhu,

Sheng Jing

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 11, 2024

Cardiopulmonary exercise test (CPET) is a common method for preliminary evaluating coronary heart disease (CHD), but it may experience false positive. The present study aimed to reveal the potential factors relating positive of CPET, including blood glucose and lipids.

Language: Английский

Citations

0