Protective effects of Fagopyrum dibotrys on oxidized oil-induced oxidative stress, intestinal barrier impairment, and altered cecal microbiota in broiler chickens

Poultry Science, Journal Year: 2023, Volume and Issue: 102(4), P. 102472 - 102472

Published: Jan. 5, 2023

The objective of this study was to evaluate protective effects Fagopyrum dibotrys on antioxidant ability, intestinal barrier functions, and cecal microbiota in broiler chickens fed oxidized soybean oil. A total 640 male Tiejiaoma broilers were randomly assigned 8 treatments with cages (10 birds per cage), as follows: basal diets containing fresh oil 0, 0.5, 1, or 2% F. (FSCON, FSFAL, FSFAM, FSFAH, respectively), (OSCON, OSFAL, OSFAM, OSFAH). Oxidized significantly decreased transcription Nrf2 its downstream genes, including CAT SOD1 the jejunal mucosa, increased mucosa IL-6 mRNA expression, IL-22 expression downregulated Claudin-1 ZO-1; however, all these reversed by dibotrys. Either 1 alleviated liver SOD induced d 42. GPX, MDA adding mucosa. In addition, based 16S rDNA, promoted Firmicutes phylum Candidatus_Arthromitus genera, but suppressed Proteobacteria Streptococcus, Enterococcus, Escherichia genera. summary, oxidative stress ameliorated upregulating genes restore redox balance, reinforcing via higher Claudin-1/ZO-1, ameliorating inflammatory response regulating IL-22, facilitating growth Candidatus_arthromitus cecum. Therefore, has potential a feed additive for poultry caused oil, enhancing function, improving gut microbiome composition.

Language: Английский

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Maternal Gut Inflammation Aggravates Acute Liver Failure Through Facilitating Ferroptosis via Altering Gut Microbial Metabolism in Offspring

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Microbial transmission from mother to infant is important for offspring microbiome formation and health. However, it unclear whether maternal gut inflammation (MGI) during lactation influences mother‐to‐infant microbial microbiota disease susceptibility. In this study, found that MGI altered the of suckling pups by shaping in mammary glands. MGI‐induced changes lasted into adulthood, resulting exacerbation acute liver failure (ALF) caused acetaminophen (APAP) offspring. Specifically, reduced abundance Lactobacillus reuteri ( L. ) its metabolite indole‐3‐acetic acid (IAA) level adult IAA alleviated ALF mice promoting intestinal IL‐22 production. Mechanistically, limits APAP‐induced excessive oxidative stress ferroptosis activating STAT3. The abundances are inversely associated with progression patients ALF. Overall, study reveals role development offspring, highlighting potential strategies intervention based on IAA‐IL‐22‐STAT3 axis.

Language: Английский

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Maternal immunoglobulins differentially bind a diverse bacterial community in human colostrum and the stool of breastfed neonates.

Immunology Letters, Journal Year: 2025, Volume and Issue: unknown, P. 106978 - 106978

Published: Feb. 1, 2025

In the early days, maternal immunoglobulins are essential for sustaining a balanced gut environment by influencing interaction between host and microbiome. The successional establishment of pioneer strains is an interesting topic research where appear to be important. This proof-of-concept study explored binding pattern IgA1, IgA2, IgM, IgG classes commensal bacterial in human colostrum stool breastfed neonates. We used flow cytometry coupled with 16S rRNA gene sequencing neonatal feces samples characterize this Ig-microbiota association. observed that samples, IgA2 IgM bind alfa beta Proteobacteria, which can potentially stimulate immune system development gut. Other like predominantly facultative anaerobes belonging Firmicutes phylum, reported as part milk microbiota colonizers Maternal also wide diversity bacteria stool. For instance, bound more members phylum Bacteroidetes comparison IgG, these some firmicutes have been late gut, their presence important due ability produce short chain fatty acids propionate butyrate. Our results support current view microbial immunoglobulin transference crucial developing neonate's individual microbiota.

Language: Английский

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Insights into the relationship between the acetylation of Dendrobium officinale polysaccharides and the ability to promote sIgA secretion

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140764 - 140764

Published: Feb. 7, 2025

Language: Английский

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Epidemiology and Mortality Risk of Severe Viral Pneumonia During the Pre-Pandemic, COVID-19 Pandemic and Post-Pandemic Era: A Retrospective Study of Hospitalized Children in ShenZhen, China Between 2017 and 2023

Journal of Epidemiology and Global Health, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 3, 2025

This study aims to investigate the spectrum of viruses leading severe viral pneumonia (SVP) and associated risk factors for mortality among pediatric patients in intensive care unit (PICU). Taking outbreak end COVID-19 pandemic as a aboundary, The pre-pandemic period spans from 01/2017 12/2019, 01/2020 12/2021, post-pandemic 01/2022 12/2023. Patients were subsequently stratified into survivor non-survivor groups based on clinical outcomes. A total 1007 (median age 1.42 years, range 0.58-4.00; male: female ratio 1.7:1) diagnosed with SVP. Cases (n = 419, 41.6%), 272, 27.0%), 316, 31.4%) periods. Viral predominance varied across phases: Pre-pandemic: Influenza (IVA, 37.0% [155/419]), respiratory syncytial virus (RSV, 29.8%), adenovirus (19.8%), influenza B (15.5%). Pandemic phase: Human rhinovirus (HRV, 40.1% [109/272]), RSV (33.1%), parainfluenza (11.4%), bocavirus (HBoV, 10.7%). Post-pandemic: HRV (24.4% [77/316]), (22.8%), HBoV (14.2%), IVA (13.6%). Comparative analysis revealed significant intergroup differences proportion aged < 3 primary immunodeficiency disorders (PIDs), sepsis between pure infection deaths coinfection-associated fatalities SVP cases. Logistic regression identified eight independent predictors: acute leukemia, other malignant tumors, PIDs, moderate-to-severe underweight, rhabdomyolysis, distress syndrome (ARDS), infection-related encephalopathy, multiorgan dysfunction (MODS). prediction model demonstrated robust discriminative capacity mortality: sensitivity 73.8%, specificity 90.2%, AUC 0.888 (95%CI 0.838-0.938) via ROC curve analysis. has altered landscape causing children. presence underlying health conditions, particularly malignancies, immunodeficiency, significantly increases death children pneumonia. offers reliable tool practice predict these patients.

Language: Английский

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Maternal consumption of urbanized diet compromises early-life health in association with gut microbiota

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 2, 2025

Urbanization has significantly transformed dietary habits worldwide, contributing to a globally increased burden of non-communicable diseases and altered gut microbiota landscape. However, it is often overlooked that the adverse effects these changes can be transmitted from mother offspring during early developmental stages, subsequently influencing predisposition various later in life. This review aims delineate detrimental maternal urban-lifestyle diet (urbanized diet) on early-life health assembly, provide mechanistic insights how urbanized mediates mother-to-offspring transfer bioactive substances both intrauterine extrauterine thus affects fetal neonatal development. Moreover, we also further propose framework for developing microbiome-targeted precision nutrition strategies specifically pregnant lactating women. The establishment such knowledge help develop proactive preventive measures beginning life, ultimately reducing long-term risk disease improving public outcomes.

Language: Английский

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Dietary Angelica sinensis Enhances Sow Lactation and Piglet Development Through Gut Microbiota and Metabolism

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(4), P. 370 - 370

Published: April 15, 2025

Piglets weaned per sow year (PSY) is a crucial metric for assessing the reproductive performances of sows and directly affects both productivity economic profitability pig farms [...]

Language: Английский

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Pilot Study of Growth Factors in Colostrum: How Delivery Mode and Maternal Health Impact IGF-1, EGF, NGF, and TGF-β Levels in Polish Women

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1386 - 1386

Published: April 20, 2025

Background: Breast milk is the most important nutrition for newborns. Growth factors such as insulin-like growth factor 1 (IGF-1), epidermal (EGF), transforming factor-β (TGF-β), and nerve (NGF) are among its components that play pivotal roles in neonatal development, immune system priming, gastrointestinal maturation. This study examined effects of gestational diabetes mellitus (GDM), maternal hypothyroidism, method delivery on concentrations these colostrum collected at three distinct postpartum time points. Methods: A group 39 women was included, 20 whom gave birth vaginally, whereas caesarean section performed 19 patients. total 18 volunteers were diagnosed with GDM, 17 suffered from hypothyroidism. Colostrum samples first 3 days after under hospital conditions. like IGF-1, EGF, NGF, TGF-β measured using commercial immunoenzymatic assays. Results: No significant differences observed values parameters between groups (with GDM or hypothyroidism healthy, well giving naturally by section). In addition, exhibited good stability within few (CVs all studied parameters: range 0.7–5.0%). Conclusions: The pregnancy disorders properly controlled treated specialists appeared not to affect levels analyzed factors—just type day collection.

Language: Английский

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The ontogeny of immune tolerance: a model of the early-life gut microbiome and adaptive immunity

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract To achieve immune and microbial homeostasis during adulthood, the developing system must learn to identify which microbes tolerate defend against. How such ‘immune education’ unfolds remains a major knowledge gap. We address this gap by synthesizing existing literature develop mechanistic mathematical model representing interplay between gut ecology adaptive immunity in early life. Our results indicate that inflammatory tone of microenvironment is mediator information flow from pre- post- weaning periods. evaluate power postnatal fecal samples for predicting immunological trajectories, explore breastfeeding scenarios when maternal conditions affect breastmilk composition. work establishes quantitative basis ’immune education’, yielding insights into questions applied relevance.

Language: Английский

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Role of maternal milk in providing a healthy intestinal microbiome for the preterm neonate

Pediatric Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Language: Английский

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