Use of fermented Chinese medicine residues as a feed additive and effects on growth performance, meat quality, and intestinal health of broilers

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: March 28, 2023

Introduction The purpose of this research was to investigate how dietary supplementation with fermented herbal residues (FCMR) affected birds' development capacity, quality meat, gut barrier, and cecum microbiota. Methods 540 cyan-shank partridge birds aged 47 days were chosen divided into two groups six replicates each 45 for replicate. control group (CON) received a basal diet, while the trial decreased basic diet containing 5% FCMR. Results discussion findings revealed that addition FCMR FCR increased ADG in broilers ( P < 0.05). Adding steaming loss broiler chicken breasts p Supplementation significantly enhanced VH/CD VH bird's intestine (jejunum, duodenum, ileum) In addition, down-regulated mRNA expression INF-γ, IL-6, IL-1β, TNF-α up-regulated ZO-1, Occludin, Claudin Microbial 16S rDNA high-throughput sequencing study supplements modified microbiota, α-diversity analysis showed reduced bacterial abundance At phylum level, relative Spirochaetota considerably following cecum's close lot Prevotellaceae_UCG-001 0.05), Desulfovibrio, Muribaculaceae , Fusobacterium 0.05) when supplemented. can promote growth capacity maintain intestinal health by enhancing barrier function modulating inflammatory response microbial composition.

Language: Английский

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Dietary curcumin supplementation alleviates diquat-induced oxidative stress in the liver of broilers

Poultry Science, Journal Year: 2023, Volume and Issue: 102(12), P. 103132 - 103132

Published: Sept. 20, 2023

This study purposed to investigate the alleviating effect of dietary curcumin supplementation on oxidative stress in liver broilers induced by diquat. One-day-old Cobb (400) were selected and randomly divided into 5 groups, with 8 replicates 10 per replicate. The control group diquat fed basal diet, while groups diet supplemented different amounts (50, 100, 150 mg/kg). On d 21 test, 1 broiler was from each replicate intraperitoneally injected 20 mg/mL solution at a dose mL/kg BW or equivalent physiological saline (for group). After 48 h feeding, slaughtered for analysis. results show that treatment reduced antioxidant capacity liver, caused stress, affected its lipid metabolism. However, using completely partially reversed broilers. blood alanine aminotransferase activity, total bilirubin protein levels, Caspase-3 mRNA abundance lower significantly than (P < 0.05). had higher activity but malondialdehyde triglyceride level activities cetyl coenzyme A carboxylase mg/kg DQ In conclusion, could ameliorate effects diquat-induced capacity, tissue morphology, metabolism broilers, thus protecting liver. recommended dosage diets is 100 curcumin.

Language: Английский

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Modulating effects of mycotoxin and oxidized oil on intestinal microbiota in broiler chickens

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0314821 - e0314821

Published: March 3, 2025

Climatic change and increased use of alternative sources feed ingredients could influence poultry production. Mycotoxin oxidized oil are two contaminations that may occur in chicken as a result climate ingredients, these factors have differential potentially additive effects on birds' intestinal microbiota. The study objective was to determine the main corn, quality, their interaction ileal content, scrapings, cecal whole cecum (content tissue) microbiota broiler chickens. Broiler chickens were raised for 21 days post-hatch fed diet made with regular or mycotoxin-contaminated corn (7,959 ppb deoxynivalenol, 2.1 ppm aflatoxin, 23,200 fumonisin, 1,403 zearalenone), (148 meq/kg) oil. Bacterial genomic DNA extracted sequenced targeting variable (V3-V4) region 16S gene. bioinformatic statistical analysis data showed mycotoxin by richness evenness content only content. also beta diversity based variability microbial community while increasing abundance bacterial taxa, including Streptomyces Escherichia-Shigella, predicted pathways related RNA synthesis (Mycothiol pyrimidine deoxyribonucleotides synthesis) redox regulation (ergothioneine biosynthesis) glycol metabolism degradation amino acids has been associated detoxication, its increase reduce negative mycotoxins contrary which negatively correlated weight gain These results show alone combination affect mostly ileum metabolic across sections.

Language: Английский

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Effects of oxidized soybean meal and oxidized soybean oil on growth, intestinal oxidative stability, inflammation, structure, digestive and absorptive capacity of Megalobrama amblycephala

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742394 - 742394

Published: March 1, 2025

Language: Английский

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Dietary Supplementation of Ancientino Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2798 - 2798

Published: June 19, 2023

Ancientino, a complex dietary fiber supplement mimicking the ancient diet, has improved chronic heart failure, kidney function, and constipation. However, its effect on ulcerative colitis is unknown. This study explores impact of Ancientino caused by dextran sulfate sodium (DSS) mechanisms. Data analyses showed that alleviated bodyweight loss, colon shortening injury, disease activity index (DAI) score, regulated levels inflammatory factors (tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), interleukin-1 beta (IL-1β), interleukin 6 (IL-6)), reduced intestinal permeability (d-lactate endotoxin), fluorescein isothiocyanate-dextran (FITC-dextran), diamine oxidase (DAO), repaired colonic function (ZO-1 occludin), suppressed oxidative stress (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA)) in vivo vitro. In short, this demonstrated alleviates exerts an anticolitis reducing response, suppressing stress, repairing barrier function. Thus, may be effective therapeutic resource for colitis.

Language: Английский

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Zhishi Daozhi decoction alleviates constipation induced by a high-fat and high-protein diet via regulating intestinal mucosal microbiota and oxidative stress

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 18, 2023

Background A growing body of evidence has demonstrated that a high-fat and high-protein diet (HFHPD) causes constipation. This study focuses on understanding how the use Zhishi Daozhi decoction (ZDD) affects intricate balance intestinal microorganisms. The insights gained from this investigation hold potential to offer practical clinical approaches mitigate constipation-related issues associated with HFHPD. Materials methods Mice were randomly divided into five groups: normal (MN) group, natural recovery (MR) low-dose ZDD (MLD) medium-dose (MMD) high-dose (MHD) group. After constipation model was established by HFHPD combined loperamide hydrochloride (LOP), different doses used for intervention. Subsequently, contents cholecystokinin (CCK) calcitonin gene-related peptide (CGRP) in serum, superoxide dismutase (SOD), malondialdehyde (MDA) liver determined. DNA mucosa extracted, 16S rRNA amplicon sequencing analyze changes mucosal microbiota. Results treatment, CCK content MR group decreased CGRP increased, but not significant. In addition, SOD significantly lower than MLD, MMD, MHD groups, MDA higher MN, groups. Constipation modeling intervention changed structure induced HFHPD, relative abundance pathogenic bacteria such as Aerococcus, Staphylococcus, Corynebacterium, Desulfovibrio, Clostridium , Prevotella increased. ZDD, these decreased, Candidatus Arthromitus Tropane, piperidine, pyridine alkaloid biosynthesis pathways increased Conclusion can increase mucosa, while effectively relieve constipation, reduce bacteria, alleviate oxidative stress injury. beneficial which is more conducive treatment

Language: Английский

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The Effects of 1-Deoxynojirimycin from Mulberry on Oxidative Stress and Inflammation in Laying Hens and the Direct Effects on Intestine Epithelium Cells In Vitro

Animals, Journal Year: 2023, Volume and Issue: 13(18), P. 2830 - 2830

Published: Sept. 6, 2023

The intestine is highly vulnerable to various factors and has been proposed as a promising determinant for poultry health. Phytogenic or plant-derived feed additives can be used help improve intestinal In this study, we aimed investigate the effects of DNJ on antioxidative parameters, including malondialdehyde (MDA), total superoxide dismutase (T-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), inflammatory cytokines (IL-6, IL-1β, TNF-α), in plasma tissues using layers supplemented with without extract mulberry leaves (DNJ-E) via ELISA method. A 192 healthy Hy-Line Brown layers, aged 47 weeks old, were conduct 56-day study. All hens randomly separated into four groups follows: basal diet containing 0 mg/kg DNJ-E(CON), 50 mg/kg, 100 150 DNJ-E. Furthermore, potential mechanism by which influences function was also investigated vitro cultured epithelium cells (IEC) quantification methods use cell counting kit-8 (CCK8), ELISA, qRT-PCR, ROS detection. results showed that CAT significantly increased following DNJ-E supplementation. Moreover, supplementation associated increases T-SOD jejunum ileum. However, there no significant difference between vivo experiments. Subsequent IEC studies revealed viability 5 µM 10 treatments while decreasing 20 treatment. Antioxidative parameters improved at concentrations. ameliorative antioxidant observed under expression levels Nrf2 mRNA treatment changes genes cytokines. conclusion, our study could oxidative stress inflammation responses chicken intestine. These findings provide theoretical reference development functional regulate health lay foundation systematically revealing DNJ.

Language: Английский

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Oleanolic acid improves antioxidant capacity and the abundance of Faecalibacterium prausnitzii in the intestine of broilers

Poultry Science, Journal Year: 2024, Volume and Issue: 103(12), P. 104340 - 104340

Published: Sept. 26, 2024

Language: Английский

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Some species of the genus Fagopyrum: chemical composition, pharmacological effects, prospects of use

chemistry of plant raw material, Journal Year: 2024, Volume and Issue: 1, P. 31 - 56

Published: Feb. 7, 2024

This review analyzes and summarizes the information of research by domestic foreign scientists on chemical composition, pharmacological activity metabolites plants genus Fagopyrum. The Fagopyrum, a member Polygonaceae family, includes 15 species, most them are cultivated an industrial scale territory Russian Federation, China, India, Indonesia North American countries. greatest interest in medicine pharmacy is represented four types buckwheat: seed buckwheat (Fagopyrum esculentum) Tatar tataricum), perennial dibotrys) red-stem rubricaulis). These widely used traditional Tibet, for treatment lung diseases, skin, edematous syndromes infectious diseases. Currently, more than 150 compounds related to flavonoids, phenylpropanoids, tannins, phagopyritols, triterpenoids, steroids, fatty acids, essential oils, alkaloids, anthraquinones, coumarins, vitamins, amino macro- microelements have been isolated identified from studied species. Extracts individual wide range effects: antitumor, antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic, antiallergic, antibacterial, angioprotective adaptogenic. given indicates that Fagopyrum promising further study use various industries.

Language: Английский

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Fagopyrum dibotrys extract improves nonalcoholic fatty liver disease via inhibition of lipogenesis and endoplasmic reticulum stress in high-fat diet-fed mice

BMC Research Notes, Journal Year: 2024, Volume and Issue: 17(1)

Published: Oct. 16, 2024

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, presenting a treatment challenge due to limited options. Endoplasmic reticulum (ER) stress and associated lipid metabolism disorders are main causes NAFLD, making it important inhibit ER for effective treatment. Fagopyrum dibotrys has hypolipidemic, anti-inflammatory hepatoprotective properties, showing promise in treating NAFLD. However, its effects on NAFLD remain unclear. This study used high-fat diet (HFD) establish mouse models supplemented with extract (FDE) evaluate therapeutic effect underlying mechanisms.

Language: Английский

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