The long and winding road of faecal microbiota transplants to targeted intervention for improvement of immune checkpoint inhibition therapy DOI Creative Commons

Jasmijn I. Verhoef,

Ediz Klont,

Frans J. van Overveld

et al.

Expert Review of Anticancer Therapy, Journal Year: 2023, Volume and Issue: 23(11), P. 1179 - 1191

Published: Sept. 25, 2023

Immune checkpoint inhibition (ICI) therapy has revolutionized the treatment of cancer. Inhibitory molecules, either on tumor or cells immune system, are blocked, allowing system patient to attack and eradicate tumor. Not all patients respond ICI therapy, response non-response been associated with composition gut microbiota.Fecal microbiota transplantation (FMT) is used as adjunctive in order improve outcome ICI. ClinicalTrials.gov, other databases were searched (October 2022) for studies dealing modification ICI.There ample evidence beneficial effect FMT cancer, especially melanoma. Progress being made unraveling mechanisms by which their metabolites (butyrate tryptophan metabolite indole-3-aldehyde) interact mucosal host. A better understanding involved will allow identification key bacterial species mediate FMT. Promising Faecalibacterium prausnitzii, Eubacterium rectale, Bifidobacterium adolescentis, B. bifidum, longum, because they important direct indirect butyrate producers.

Language: Английский

Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment DOI Creative Commons
Mackenzie Bender,

Alex McPherson,

Catherine M. Phelps

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(9), P. 1846 - 1862.e26

Published: April 1, 2023

Language: Английский

Citations

342
Intratumoural microbiota: a new frontier in cancer development and therapy DOI Creative Commons

Yaqi Cao,

Hui Xia,

Xueyun Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 10, 2024

Abstract Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of which have been confirmed to be closely related oncogenesis. The concept intratumoural microbiota was subsequently proposed. Microbiota could colonise through mucosal destruction, adjacent tissue migration, hematogenic invasion affect the biological behaviour tumours as an important part microenvironment. Mechanistic demonstrated potentially promote initiation progression by inducing genomic instability mutations, affecting epigenetic modifications, promoting inflammation response, avoiding immune regulating metabolism, activating metastasis. Since more comprehensive profound insights about intratumoral are continuously emerging, new methods for early diagnosis prognostic assessment cancer patients under examination. In addition, interventions based on show great potential open chapter antitumour therapy, especially immunotherapy, although there some inevitable challenges. Here, we aim provide extensive review concept, development history, sources, heterogeneity, carcinogenic mechanisms explore role microorganisms prognosis, discuss current treatment regimens target research prospects limitations this field.

Language: Английский

Citations

86
The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects DOI Creative Commons
C.-L. Li, Kaixin Peng,

Siqi Xiao

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Sept. 29, 2023

Abstract Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn’s (CD). IBD closely related to systemic reaction affects the progression many extraintestinal diseases. As one representative bacteria for probiotic-assisted therapy in IBD, multiple strains Lactobacillus have been proven alleviate damage strengthen immunological barrier, epithelial cell mucus barrier. also spares no effort alleviation IBD-related diseases such as Colitis-associated Colorectal cancer (CAC), Alzheimer’s (AD), Depression, Anxiety, Autoimmune Hepatitis (AIH), so on via gut-brain axis gut-liver axis. This article aims discuss role diseases, including its underlying mechanisms curative strategies from present future.

Language: Английский

Citations

75
Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review) DOI Creative Commons

Jinzhe Sun,

Shiqian Chen,

Dan Zang

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(4)

Published: Feb. 29, 2024

Cancer is one of the leading causes mortality worldwide. The etiology cancer has not been fully elucidated yet, and further enhancements are necessary to optimize therapeutic efficacy. Butyrate, a short‑chain fatty acid, generated through gut microbial fermentation dietary fiber. Studies have unveiled relevance butyrate in malignant neoplasms, comprehensive understanding its role imperative for realizing full potential oncological treatment. Its antineoplastic effects via activation G protein‑coupled receptors inhibition histone deacetylases also confirmed. However, underlying mechanistic details remain unclear. present study aimed review involvement carcinogenesis molecular mechanisms, with particular emphasis on association efficacy tumor immunotherapy, as well discussing relevant clinical studies target neoplastic diseases provide new insights into

Language: Английский

Citations

39
Immunopathogenesis of Primary Biliary Cholangitis, Primary Sclerosing Cholangitis and Autoimmune Hepatitis: Themes and Concepts DOI
Palak Trivedi, Gideon M. Hirschfield, David H. Adams

et al.

Gastroenterology, Journal Year: 2024, Volume and Issue: 166(6), P. 995 - 1019

Published: Feb. 10, 2024

Language: Английский

Citations

25
Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity DOI Creative Commons
Amanda Lee, David Álvarez Jiménez, Marlies Meisel

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. historical roots of probiotics are traced back to Nobel Laureate Élie Metchnikoff, who linked the longevity Bulgarian villagers their consumption sour milk fermented by Lactobacilli. His pioneering work led global recognition as beneficial supplements, now multibillion-dollar industry. Modern have been extensively studied for immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), widely used probiotic, has garnered significant attention its systemic immune-regulatory properties, particularly relation autoimmunity cancer. This review delves into L. modulating immune responses, with focus on impact diseases.

Language: Английский

Citations

6
Translocating gut pathobiont Enterococcus gallinarum induces T H 17 and IgG3 anti-RNA–directed autoimmunity in mouse and human DOI

Konrad Gronke,

Mytien Nguyen,

H. Fuhrmann

et al.

Science Translational Medicine, Journal Year: 2025, Volume and Issue: 17(784)

Published: Feb. 5, 2025

Chronic autoimmune diseases often lead to long-term sequelae and require lifelong immunosuppression because of an incomplete understanding the triggers drivers in genetically predisposed patients. Gut bacteria that escape gut barrier, known as translocating pathobionts, have been implicated instigators perpetuators extraintestinal mice. The microbial contributions autoimmunity humans remain largely unclear, including whether specific pathological human adaptive immune responses are triggered by such pathobionts. Here, we show pathobiont Enterococcus gallinarum can induce both mouse interferon-γ + T helper 17 (T H 17) differentiation immunoglobulin G3 (IgG3) subclass switch anti– E. RNA antibodies, which correlated with anti-human autoantibody patients systemic lupus erythematosus (SLE) hepatitis, two diseases. RNA, but not Toll-like receptor 8 (TLR8), TLR8-mediated monocyte activation promoted induction . Translocation increased anti-RNA titers renal pathophysiology murine gnotobiotic models disease activity SLE. These studies elucidate cellular mechanisms how a induces cell– B cell–dependent provide framework for developing host- microbiota-derived biomarkers targeted therapies

Language: Английский

Citations

3
The Role of Inflammation in the Initiation and Progression of Myeloid Neoplasms DOI
Juan Carlos Balandrán, Audrey Lasry, Iannis Aifantis

et al.

Blood Cancer Discovery, Journal Year: 2023, Volume and Issue: 4(4), P. 254 - 266

Published: April 13, 2023

Myeloid malignancies are devastating hematologic cancers with limited therapeutic options. Inflammation is emerging as a novel driver of myeloid malignancy, important implications for tumor composition, immune response, options, and patient survival. Here, we discuss the role inflammation in normal malignant hematopoiesis, from clonal hematopoiesis to full-blown leukemia. We how shapes output hematopoietic stem cells, alters microenvironment bone marrow, therapies aimed at targeting disease.

Language: Английский

Citations

23
The aryl hydrocarbon receptor in immune regulation and autoimmune pathogenesis DOI
Wei Huang, Ke Rui,

X Wang

et al.

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 138, P. 103049 - 103049

Published: May 23, 2023

Language: Английский

Citations

19
The role of the microbiome in liver disease DOI
David Schöler, Bernd Schnabl

Current Opinion in Gastroenterology, Journal Year: 2024, Volume and Issue: 40(3), P. 134 - 142

Published: Feb. 16, 2024

Purpose of review The intestinal microbiome and the gut-liver axis play a major role in health disease. human gut harbors trillions microbes disruption homeostasis can contribute to liver In this review, progress field within last 3 years is summarized, focusing on metabolic dysfunction-associated steatotic disease (MASLD), alcohol-associated (ALD), autoimmune (AILD), hepatocellular carcinoma (HCC). Recent findings Changes fecal virome fungal mycobiome have been described patients with various diseases. Several microbial derived metabolites including endogenous ethanol produced by bacteria, mechanistically linked such as MASLD. Virulence factors encoded bacteria ALD, AILD HCC. Novel therapeutic approaches focused phages, pre- postbiotics successfully used preclinical models. Fecal microbiota transplantation has effective attenuating Probiotics are safe hepatitis improve alcohol addiction. Summary gut–liver plays key pathophysiology Understanding help develop precise centered therapies.

Language: Английский

Citations

7