Upregulation of Lactobacillus spp . in gut microbiota as a novel mechanism for environmental eustress-induced anti-pancreatic cancer effects DOI Creative Commons
Yiyi Liang, Min Du, Xin Li

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 23, 2025

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited effective treatment options. Emerging evidence links enriched environment (EE)-induced eustress to PDAC inhibition. However, the underlying mechanisms remain unclear. In this study, we explored role of gut microbiota in PDAC-suppressive effects EE. We demonstrated that depletion antibiotics abolished EE-induced tumor suppression, while fecal transplantation (FMT) from EE mice significantly inhibited growth both subcutaneous and orthotopic models housed standard environment. 16S rRNA sequencing revealed enhanced diversity selectively probiotic Lactobacillus, particularly L. reuteri. Treatment reuteri suppressed increased natural killer (NK) cell infiltration into microenvironment. Depletion NK cells alleviated anti-tumor reuteri, underscoring essential cell-mediated immunity response. Clinical analysis patients showed higher Lactobacillus abundance correlated improved progression-free overall survival, further supporting therapeutic potential PDAC. Overall, study identifies as systemic regulator under psychological stress. Supplementation psychobiotic may offer novel strategy for

Language: Английский

Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review DOI Creative Commons
Teng Ma, Xin Shen, Xuan Shi

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 178 - 198

Published: June 11, 2023

The human gut hosts complex microbial communities, which are linked to health and disease. microbiota is continuously reshaped by multiple environmental factors, especially diet. Gut dysbiosis may promote various metabolic, neurological, intestinal, cardiovascular diseases, even tumor development. Probiotics have shown promising prophylactic, mitigating, or curative effects when use as nutrient supplements adjunctive therapy. These beneficial and/or symptom alleviation often accompanied microbiome metabolome changes. Differing from other published review articles, here we summarized the latest knowledge of evidence-based health-promoting probiotics scouring literature recent animal probiotic intervention studies. To elucidate mechanisms in enhancing intestinal homeostasis, barrier function, host immunity, through modulating its metabolites. Meanwhile, also discussed challenges data analysis clinical research comparison between laboratories, provides an outlook for future perspectives applications probiotics. achieved modulation. Current discussed. Finally, provided.

Language: Английский

Citations

146
Probiotics, prebiotics, and postbiotics in health and disease DOI Creative Commons
Jing Ji, Weilin Jin, Shuang‐Jiang Liu

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(6)

Published: Nov. 4, 2023

The gut microbiota and its homeostasis play a crucial role in human health. However, for some diseases related to the microbiota, current traditional medicines can only relieve symptoms, it is difficult solve root causes or even cause side effects like disturbances microbiota. Increasing clinical studies evidences have demonstrated that probiotics, prebiotics, postbiotics prevent treat various diseases, but currently they be used as dietary supplements rather than medicines, which restricts application of probiotics field medicine. Here, this review analyzes importance health problems systematically summarizes effectiveness mechanisms maintaining treating based on animal models trials. And research outcomes development trends field, challenges prospects their health, alleviating are analyzed. It hoped promote disease treatment open up new frontiers probiotic research.

Language: Английский

Citations

144
γδ T cells: origin and fate, subsets, diseases and immunotherapy DOI Creative Commons
Yi Hu,

Qinglin Hu,

Yongsheng Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 22, 2023

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering use allogeneic Vδ2

Language: Английский

Citations

111
Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy DOI
Andrew Maltez Thomas, Marine Fidelle, Bertrand Routy

et al.

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(9), P. 583 - 603

Published: June 26, 2023

Language: Английский

Citations

73
Bifidobacterium mechanisms of immune modulation and tolerance DOI Creative Commons
Samuel J. Gavzy, Allison Kensiski,

Zachariah L Lee

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Dec. 6, 2023

Bifidobacterium is a widely distributed commensal bacterial genus that displays beneficial pro-homeostatic and anti-inflammatory immunomodulatory properties. Depletion or absence of in humans model organisms associated with autoimmune responses impaired immune homeostasis. At the cellular level, upregulates suppressive regulatory T cells, maintains intestinal barrier function, modulates dendritic cell macrophage activity, dampens Th2 Th17 programs. While there has been large volume literature characterizing probiotic properties various Bifidobacterial species, likely multifactorial mechanisms underlying these effects remain elusive, particular, its tolerogenic effect. However, recent work shed light on surface structural polysaccharide protein elements, as well metabolic products, mediators This review aims to discuss several utilizes for modulation their indirect impact regulation gut microbiome structure from molecules produced metabolites. These are pertinent an increasingly networked understanding tolerance homeostasis health disease.

Language: Английский

Citations

71
Intratumoural microbiota: a new frontier in cancer development and therapy DOI Creative Commons

Yaqi Cao,

Hui Xia,

Xueyun Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 10, 2024

Abstract Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of which have been confirmed to be closely related oncogenesis. The concept intratumoural microbiota was subsequently proposed. Microbiota could colonise through mucosal destruction, adjacent tissue migration, hematogenic invasion affect the biological behaviour tumours as an important part microenvironment. Mechanistic demonstrated potentially promote initiation progression by inducing genomic instability mutations, affecting epigenetic modifications, promoting inflammation response, avoiding immune regulating metabolism, activating metastasis. Since more comprehensive profound insights about intratumoral are continuously emerging, new methods for early diagnosis prognostic assessment cancer patients under examination. In addition, interventions based on show great potential open chapter antitumour therapy, especially immunotherapy, although there some inevitable challenges. Here, we aim provide extensive review concept, development history, sources, heterogeneity, carcinogenic mechanisms explore role microorganisms prognosis, discuss current treatment regimens target research prospects limitations this field.

Language: Английский

Citations

69
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition DOI
Weiwei Cui, Meng Guo, Dong Liu

et al.

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(1), P. 124 - 137

Published: Jan. 1, 2024

Language: Английский

Citations

67
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions DOI

Jingjing Cong,

Pianpian Liu,

Zili Han

et al.

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 876 - 889.e11

Published: March 12, 2024

Language: Английский

Citations

66
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential DOI Creative Commons

Yu-Ling Xiao,

Yue Gong,

Ying-Jia Qi

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 11, 2024

Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies

Language: Английский

Citations

66
Ferroptosis: principles and significance in health and disease DOI Creative Commons
Fangquan Chen, Rui Kang, Daolin Tang

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: June 6, 2024

Abstract Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic pathway in 2012, ferroptosis has emerged crucial mechanism numerous physiological pathological contexts, leading to significant therapeutic advancements across wide range diseases. This review summarizes the fundamental mechanisms regulatory pathways underlying ferroptosis, including both GPX4-dependent -independent antioxidant mechanisms. Additionally, we examine involvement various conditions, cancer, neurodegenerative diseases, sepsis, ischemia–reperfusion injury, autoimmune disorders, metabolic disorders. Specifically, explore role response chemotherapy, radiotherapy, immunotherapy, nanotherapy, targeted therapy. Furthermore, discuss pharmacological strategies for modulating potential biomarkers monitoring this process. Lastly, elucidate interplay between other forms regulated death. Such insights hold promise advancing our understanding context human health disease.

Language: Английский

Citations

51