The Causal Relationship between Gut Microbiota and Non-alcoholic Fatty Liver Disease: A Mendelian Randomization Study DOI Creative Commons

Liwei Li,

Fuqing Cai,

Guang Xiong

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Abstract Aims The association between the gut microbiota and non-alcoholic fatty liver disease (NAFLD) has been documented; however, causal relationship them remains unclear. aim of this study was to explore NAFLD using Mendelian randomization. Methods We conducted a randomization study, data (n = 18340) from MiBioGen consortium as exposure dataset FinnGen R9 release 377,277) outcome. Inverse variance weighted employed primary analysis method, sensitivity performed. Additionally, network graph resembling phylogenetic tree created further reveal evolutionary relationships among microbiota. Results Six bacterial features exhibited with NAFLD: Actinomycetales (OR 1.50, 95% CI: 1.01–2.21, p 0.043), Actinomycetaceae 1.49, 1.01–2.20, Actinomyces 1.36, 1.09–1.71, 0.006), Prevotella 7 1.19, 1.01–1.39, 0.039) potential detrimental effects on NAFLD, whereas Anaerofilum 0.85, 0.72–0.99, 0.042) Gordonibacter 0.84, 0.72–0.98, 0.024) protective effects. Furthermore, , are located same branch. Conclusions Our revealed six bacteria NAFLD. These findings shed light role specific in pathogenesis offer valuable insights into future therapeutic interventions preventive strategies.

Language: Английский

Estimates of microbiome heritability across hosts DOI
Andrew H. Morris, Brendan J. M. Bohannan

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(12), P. 3110 - 3119

Published: Nov. 15, 2024

Language: Английский

Citations

2
Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives DOI Creative Commons
Lusheng Huang, Congying Chen

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 30, 2023

The gut microbiota is a complex and diverse ecosystem comprised of trillions microbes plays an essential role in host's immunity, metabolism, even behaviors. Environmental host factors drive the huge variations microbiome among individuals. Here, we summarize accumulated evidences about genetic effect on microbial compositions with emphases correlation between kinship similarity compositions, heritability estimates taxa, identification genomic variants associated pigs as well humans. A proportion bacterial taxa have been reported to be heritable, numerous diversity or specific identified both humans pigs. LCT ABO gene replicated multiple studies, its mechanism elucidated clearly. We also discuss main advantages challenges using experimental animals exploring composition provided our insights perspectives this area.

Language: Английский

Citations

5
MicroRNA sensing and regulating microbiota-host crosstalk via diet motivation DOI

Yaotian Fan,

Mengran Qin, Jiahao Zhu

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(13), P. 4116 - 4133

Published: Oct. 26, 2022

Accumulating evidence has demonstrated that diet-derived gut microbiota participates in the regulation of host metabolism and becomes foundation for precision-based nutritional interventions biomarker potential individual dietary recommendations. However, specific mechanism microbiota-host crosstalk remains unclear. Recent studies have identified noncoding RNAs, as important elements initiation termination gene expression, mediate communication. Besides, cross-kingdom non-host derived microRNAs also influence via diet motivation. Hence, understanding relationship between microbiota, miRNAs, is indispensable to revealing differences motivation providing targeted recommendations strategies. In this review, we first present an overview interaction diet, genetics, collected some latest research associated with modulated intestinal homeostasis. Then, specifically described possible molecular mechanisms sensing regulating crosstalk. Lastly, summarized prospect biomarkers disease diagnosis, disadvantages We speculated could become novel circulating personalized strategies achieve precise nutrition future clinical implications.

Language: Английский

Citations

9
Gut Microbiome-Driven Metabolites Influence Skin Pigmentation in TYRP1 Mutant Oujiang Color Common Carp DOI Open Access

Roland Nathan Mandal,

Jing Ke, Nusrat Hasan Kanika

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 5, 2024

Abstract The gut microbiome is one of the major regulators gut-skin axis and partly regulated by host genetics. In present study, using comparative high-throughput omics data on CRISPR/Cas9-mediated TYRP1 mutant wild-color common carp populations, we quantified proportion inter-individual variation in skin transcriptome blood metabolome genetic architecture microbiomes. We found 525 differential metabolites (DMs) 45 microbial genera fishes relative to wild type. Through interaction analysis causal mediation analyses, revealed that TYRP1-mutant derived background may exert an inflammatory Acinetobacter - Leukotrience-C4 – Spermine metabolic pathway under regulation anti-inflammatory cardio-vascular network underlying upregulating expression COMT , PLG C2 C3 F10 TDO2 MHC1 SERPINF2 gene for evolving unusual coffee-like color phenotype. This unique appears underlie “coffee-like” propose -mediated effect atypical patterns through pathway. Article Summary R.N. Mandal et al. report microbiome-driven pattern regulatory genes It suggests Mutation rise microbiome-skin be balanced leading coloration Oujiang Color Common Carp.

Language: Английский

Citations

1
Gut microbial metabolism is linked to variations in circulating non-high density lipoprotein cholesterol DOI Creative Commons

Shiyi Zhou,

Ludi Liu,

Bingqi Ye

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 104, P. 105150 - 105150

Published: May 9, 2024

Non-high-density lipoprotein cholesterol (non-HDL-c) was a strong risk factor for incident cardiovascular diseases and proved to be better target of lipid-lowering therapies. Recently, gut microbiota has been implicated in the regulation host metabolism. However, its causal role variation non-HDL-c remains unclear. Microbial species metabolic capacities were assessed with fecal metagenomics, their associations evaluated by Spearman correlation, followed LASSO linear regression adjusted established factors. Moreover, integrative analysis plasma metabolomics performed determine key molecules linking microbial metabolism non-HDL-c. Furthermore, bi-directional mendelian randomization potential selected metabolites Decreased Eubacterium rectale but increased Clostridium sp CAG_299 causally linked higher level A total 16 found independently associated after correcting age, sex, demographics, lifestyles comorbidities, strongest association observed tricarboxylic acid (TCA) cycle. decreased 3-indolepropionic N-methyltryptamine, resulting from suppressed reductive TCA cycle, functioned as major effectors elevation circulating Overall, our findings provided insight into effects microbes on uncovered novel link between metabolism, highlighting possibility regulating microbiota-modifying interventions. full list funding bodies can Sources section.

Language: Английский

Citations

1
Early life factors shaping infant gut anellovirus composition and associations with childhood atopic disease DOI
Ulrika Boulund, Jonathan Thorsen, Frej Larsen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract The Anelloviridae family is highly prevalent and genetically diverse, but factors shaping the composition relationship with disease remain elusive. Here, we characterised faecal viromes of 647 one-year-old children from deeply phenotyped Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) mother-child cohort. In this study, anelloviruses showed immense prevalence individual variability. Early-life exposures such as being day care having older siblings were associated a reduced anellovirus abundance diversity, influenced composition. Additionally, genetic secretors FUT2 enzyme had higher compared to non-secretors. We observed an association between allergic rhinitis, no associations infections or development other atopic traits. Our findings indicate that are commensal component all infants' virome, further investigations into how immune-training influence their longitudinally pertinent.

Language: Английский

Citations

1
Gut Microbiome-Driven metabolites influence skin pigmentation in TYRP1 mutant Oujiang Color Common Carp DOI

Roland Nathan Mandal,

Jing Ke, Nusrat Hasan Kanika

et al.

Gene, Journal Year: 2024, Volume and Issue: 928, P. 148811 - 148811

Published: July 31, 2024

Language: Английский

Citations

1
Climate Change, Racism, and Food Insecurity: Cyclical Impacts of Stressors Exacerbate Health Disparities DOI Creative Commons

Christina Ek,

James R. Hébert, Daniela B. Friedman

et al.

Journal of Racial and Ethnic Health Disparities, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Introduction Disadvantaged populations have higher rates of chronic disease, including heart cancer, and diabetes. Race, ethnicity, lower socioeconomic status, poverty all contribute to these disproportionate rates. Other factors, systemic racism, climate change, poor diet, lack food access, epigenetic influences, that are distributed experienced differently across vulnerable also play a significant role in the development diseases. This comprehensive review contributors diseases emphasizes unique focus on identified emerging factors. Methods An ad hoc literature using OVID Medline Web Science was conducted. Results Findings from prior studies indicate multiple stressors, both isolation combination, their negative impacts physical mental health minorities exacerbated by change. Discussion Various stressors dramatically increase disease risk minority groups. Recommendations for future research elucidate climatic, racial, dietary adversity with presented. Further study this area is critical achieving UN Sustainable Development Goals improving public outcomes.

Language: Английский

Citations

1
Causal Link between Gut Microbiota and Infertility: A Two-sample Bidirectional Mendelian Randomization Study DOI
Jiaxin Zhang, Qinlan Li, Xiaoyan Wang

et al.

Current Medical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Language: Английский

Citations

1
Genome-wide association study (GWAS) of host germline variation and the gut microbiome: The Multiethnic Cohort Study DOI Creative Commons
Meredith A.J. Hullar, Keith R. Curtis, Yuqing Li

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 17, 2023

Abstract Patterns of microbiome diversity vary across human populations largely driven by lifestyle and environmental factors. However, differences in genetically-encoded traits the host may also be important shaping related health outcomes. We report results from a GWAS gut 5,202 individuals Multiethnic Cohort Study, including African American, Japanese Native Hawaiian, Latino, White individuals. Genotyping was derived previous studies (n = 3,337) using various Illumina Infinium arrays (660,000 to 2.5 million SNPs) MEGA EX array 1,865). Single nucleotide polymorphism (SNP) imputation conducted cosmopolitan reference panel 1000 Genomes Project. The stool assessed paired-end sequencing (Illumina MiSeq) the16S rRNA gene (V 1 − 3 ). SNP-genera association tests were ordinal logistic regression with quintiles bacterial abundance regressed on SNPs, adjusted for age, ancestry estimates, season sample collection, batch, genotyping study, genome-wide statistical significance threshold p < 5*10 8 . identified associations between 53 SNPs 11 chromosomes 16 bacterial/archaeal genera at .The coding regions categorized into broad categories: genes known exploited pathogens; involved nutrition, obesity, diabetes, cancer; immune function. Most significantly, Bifidobacterium associated 2 chromosome (rs182549 3.8*10 ; rs4988235 4.8*10 ) MCM6 that lactose intolerance overall Latinos 4.12*10 09 6.90*10 replicated other studies. A significant Coriobacteriales CDH18 (rs7701767,p 1.5*10 08 East Asian cohorts. Genetic variants non-coding primarily defenses against infection via solubilizing pathogen cell membranes, restricting growth intracellular pathogens, triggering inflammation though innate response. Fusicatenibacter SNP (rs8067381,p 1.63*10 6 found SOCS7 ARHGAP23 several cohort. Expansion cohorts include racial ethnic genetics interactions support an understanding outcomes population.

Language: Английский

Citations

1