Next generation probiotics: Engineering live biotherapeutics

Biotechnology Advances, Journal Year: 2024, Volume and Issue: 72, P. 108336 - 108336

Published: March 2, 2024

Language: Английский

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Targeting methionine metabolism in cancer: opportunities and challenges

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 395 - 405

Published: April 5, 2024

Language: Английский

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Empowering probiotics with high xanthine transport for effective hyperuricemia management

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 17, 2024

Hyperuricemia, a prevalent metabolic disorder, poses susceptibility to various complications. The conventional pharmacotherapeutic approaches for hyperuricemia often entail notable adverse effects, posing substantial clinical challenges. Hence, the imperative lies in development of novel, safe and effective strategies preventing treating hyperuricemia. Here, we developed probiotic

Language: Английский

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Methionine restriction diets: Unravelling biological mechanisms and enhancing brain health

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 149, P. 104532 - 104532

Published: May 14, 2024

Language: Английский

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Engineered bacterial therapeutics with material solutions

Trends in biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Recent advances in engineered bacterial therapeutics underscore their potential treating diseases via targeted, live interventions. Despite promising performance early clinical phases, no therapeutic bacteria have yet received approval, primarily due to challenges proving efficacy while ensuring biosafety. Material science innovations, particularly the encapsulation of within hydrogels, present a avenue enhance survival, efficacy, and safety applications. This review discusses this interdisciplinary approach develop living materials. Hydrogels not only safeguard from harsh physiological conditions but also enable controlled release prevent unintended dissemination. The strategic use materials could redefine delivery functionality therapeutics, facilitating translation.

Language: Английский

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A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy

Nutrition and Cancer, Journal Year: 2024, Volume and Issue: 76(6), P. 463 - 468

Published: April 9, 2024

Methionine is an essential amino acid critical for cell growth and survival. Preclinical evidence suggests a methionine restricted diet (MRD) sensitizes cancer to radiation therapy (RT), without significant adverse effects. However, this has never been evaluated in humans. The purpose of pilot study was evaluate the safety feasibility concurrent MRD with standard-of-care definitive RT adults any non-skin malignancy. extended from 2 wk before initiation, through beyond completion. primary endpoint assessed as rate grade 3 or higher acute late toxicities. Feasibility quantitative plasma panel every during (target 13 μM). Nine patients were accrued over two-year period, five able complete treatment course. trial closed due slow accrual subjects' difficulty maintaining diet. No events observed. Subjects' average level 18.8 μM treatment, nadir 16.8 μM. These findings suggest RT, toxicities comparable those expected alone. challenging, unacceptable most patients.

Language: Английский

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The Future of Microbiome Therapeutics

Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

The human microbiome exerts profound influence over various biological processes within the body. Unlike many host determinants, it represents a readily accessible target for manipulation to promote health benefits. However, existing commercial microbiome-directed products often exhibit low efficacy. Advancements in technology are paving way development of novel therapeutics, across wide range indications. In this narrative review, we provide an overview state-of-the-art technologies late-stage development, examining their advantages and limitations. By covering spectrum, from fecal-derived live biotherapeutics, phage therapy, synthetic biology, illuminate path toward future therapeutics.

Language: Английский

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Engineered microbial living matter for diagnostics, prevention, and therapy

Current Opinion in Biotechnology, Journal Year: 2025, Volume and Issue: 92, P. 103269 - 103269

Published: Feb. 6, 2025

Language: Английский

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Enhancing the persistence of engineered biotherapeutics in the gut: Adhesion, glycan metabolism, and environmental resistance

Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115591 - 115591

Published: April 1, 2025

Language: Английский

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Methionine Dependency and Restriction in Cancer: Exploring the Pathogenic Function and Therapeutic Potential

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 640 - 640

Published: April 28, 2025

Methionine, an essential amino acid, is obtained by dietary intake to fulfill the requirements of our bodies. Accumulating evidence indicates that methionine plays a pivotal role in various biological processes, including protein synthesis, energy metabolism, redox balance maintenance, and methylation modifications. Numerous advances underscore heightened dependence cancer cells on methionine, which significant factor pathogenesis development. A profound comprehension intricate relationship between metabolism tumorigenesis imperative for advancing field therapeutics. Herein, we delve into supporting growth, impact epigenetic modifications, interaction tumor microenvironment. Additionally, provide insights development methionine-targeted therapy strategies. This paper summarizes current state research its translational potential, emphasizing challenges opportunities associated with harnessing as target innovative treatments.

Language: Английский

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