Veterinary Clinics of North America Food Animal Practice, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative antimicrobial materials due their low cost, easy synthesis, good stability. Herein, we develop novel sprayable hydrogel based on carboxymethyl chitosan (CMCS) oxidized hyaluronic acid (OHA), incorporating Au nanoparticle-carbon nitride (AuNPs-C3N4) nanozyme, glucose, Mn2+ for bacteria-infected healing. forms rapidly in situ upon spraying gradually degrades the area, releasing AuNPs-C3N4 which exhibits robust glucose oxidase-like (GOx-like) activity, initiating comprehensive catalytic cascade through Mn2+-mediated Fenton-like reaction that generates hydroxyl radicals (•OH) eliminate Staphylococcus aureus (S. aureus) Methicillin-resistant S. (MRSA). Computational results indicate interactions between AuNPs g-C3N4 maximize synergistic effects heterojunction, improving O2 adsorption facilitating electron-O2 optimize activity. Further experiments demonstrate can cover wounds situ, while CMCS promotes collagen production fibroblast proliferation, offering viable strategy
Language: Английский
Citations
1
British Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 81
Published: Aug. 7, 2024
The global issue of antimicrobial resistance poses significant challenges to public health. World Health Organization (WHO) has highlighted it as a major health threat, causing an estimated 700,000 deaths worldwide. Understanding the multifaceted nature antibiotic is crucial for developing effective strategies. Several physiological and biochemical mechanisms are involved in development resistance. Bacterial cells may escape bactericidal actions drugs by entering physiologically dormant state known bacterial persistence. Recent findings this field suggest that persistence can be one main sources chronic infections. tolerance developed persister could tolerate high levels antibiotics give rise offspring. These offspring attributed mechanisms, especially This review attempts shed light on persister-induced current therapeutic
Language: Английский
Citations
8
Microorganisms, Journal Year: 2024, Volume and Issue: 12(10), P. 2099 - 2099
Published: Oct. 21, 2024
The contamination of surfaces by antibiotic-resistant pathogens presents an escalating challenge, especially on touchscreens in public settings such as hospitals, airports, and means transport. Traditional chemical cleaning agents are often ineffective leave behind harmful residues. Thus, the application optical radiation is gaining relevance a rapid, effective, environmentally friendly disinfection method. This study examines publicly accessible efficacy irradiation approach for microorganisms quartz with UVC LEDs. In this setup, LED laterally coupled into plate that serves cover glass simplified touchscreen model. process allows surface, without user being exposed to hazardous radiation. To assess process, range bacteria, mostly ESKAPE surrogates,
Language: Английский
Citations
4
Published: Jan. 1, 2025
The aquatic environment plays a central role in the selection and spread of antimicrobial resistance genes (ARGs). Using metagenomic approaches, several studies have provided comprehensive view resistome across different ecosystems. However, unique systems, such as oceanic blue holes, remain largely unexplored. In this study, free-living particle-associated shotgun metagenome sequencing data, collected Sansha Yongle Blue Hole (South China Sea) water column, were analyzed to reveal (total content ARGs within defined bacterial community) potential for horizontal gene transfer detected ARGs. diversity overall significantly decreased with depth, although trend was driven by community, while it remained stable communities. Additionally, latter showed higher frequency co-occurring mobile genetic elements on same contigs, frequent plasmid localization these genes. Overall, bacteria proved essential sustaining diversity. Furthermore, findings suggest potentially rate ARG microbial communities along column ensuring persistence resistances deep marine waters.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125283 - 125283
Published: Jan. 1, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Abstract Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non‐polar nature of most sonosensitizers. To address this, acid‐responsive zinc‐porphyrin‐based sonosensitizer (Zn‐TCPP) is developed via simple thermal reaction, which then coated with phenylboronic acid‐modified hyaluronic acid (B‐HA), fabricate B‐HA@Zn‐TCPP. While in mildly acidic microenvironment mimicking infected wound site, released B‐HA@Zn‐TCPP achieves effective SDT activity. The disruption membrane and levels intracellular reactive oxygen species (ROS) verified that inhibition rate can reach 99% within 5 min, without any development resistance after 15 consecutive generations culture. Additionally, under ultrasound (US) ‐mediated cavitation, exhibits excellent penetration into biofilms, achieving 90.04% bactericidal for bacteria biofilms. In vivo studies further demonstrated effectively accelerate healing wounds 98.65% 9 days. Therefore, novel offers viable strategy overcome limitations traditional sonosensitizers infections.
Language: Английский
Citations
0
Polymer Engineering and Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Abstract Antibacterial fabrics have garnered significant attention due to bacterial infection‐related public safety problems. However, the challenge of creating textiles with efficient and durable antibacterial properties remains significant. In this study, an eco‐friendly calcination technique was applied synthesize a nanostructured CuO@ZIF‐8 agent. The resulting material exhibits both performance. Polyethylene terephthalate (PET) used as fiber matrix, PET/CuO@ZIF‐8 fibers were produced using melt spinning technology. results indicate that is well dispersed within PET which promotes crystallization during cooling process. With 99.9% maximum bactericidal rate against E. coli S. aureus , altered polyester demonstrated strong activity. Furthermore, modified exhibited excellent wash resistance, maintaining rates 93.7% 92.6% after 50 washes. This work presents fresh method for producing fibers. Highlights Eco‐friendly synthesizes incorporated via well‐dispersed in PET, promoting crystallization. exhibit
Language: Английский
Citations
0
Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Language: Английский
Citations
0
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Lugdunin was the first reported new class of thiazolidine cyclopeptide antibiotic from human microbiomes. However, its structure could not accommodate polar amino acids or modules, limiting potential for chemical modification and clinical application. Herein, we developed a combinatorial strategy based on in situ tryptophan through radical reaction acid site-specific mutation, transforming lugdunin into cationic cyclic peptide antibiotic. Among derivatives lugdunin, WK6 identified as highly potent membrane-active with rapid bactericidal activity low resistance development potential. Remarkably, it showed therapeutic efficacy MRSA-infected murine models keratitis, pneumonia, peritonitis. Additionally, when grafted onto contact lens Surfaces, exhibited antifouling capabilities, highlighting implant applications. Therefore, this study an effective to optimize unveiled novel derivative WK6, which be recognized promising lead compound combat multidrug-resistant bacteria.
Language: Английский
Citations
0
Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 222 - 222
Published: Feb. 21, 2025
The discovery, commercialization, and regular administration of antimicrobial agents have revolutionized the therapeutic paradigm, making it possible to treat previously untreatable fatal infections. However, excessive use antibiotics has led develop resistance soon after their in clinical practice, point becoming a global emergency. mechanisms bacterial are manifold, including destruction or inactivation, target site modification, active efflux, represent main examples evolutionary adaptation for survival species. acquirement new is consequence great genetic plasticity bacteria, which triggers specific responses that result mutational adaptation, acquisition material, alteration gene expression, virtually producing all currently available antibiotics. Understanding processes critical development counteract drug-resistant microorganisms. In this review, both action antibiotic (AMR) genes (ARGs) mainly found environmental bacteria will be reviewed. Furthermore, background multidrug-resistant examined, some promising elements control reduce emergence spread AMR proposed.
Language: Английский
Citations
0