Mathematical modeling of swelling and shrinking dynamics in pH-sensitive hydrogels composed of alginate, anionic cellulose, and chitosan

Polymer, Journal Year: 2025, Volume and Issue: unknown, P. 128452 - 128452

Published: April 1, 2025

Language: Английский

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Bioprinting Taurine-Incorporated Gelatin Methacrylate Hydrogels for Enhanced Muscle Tissue Regeneration

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Skeletal muscle diseases like myopathies and muscular dystrophies present significant clinical challenges with few effective treatments. To better understand disease mechanisms accelerate therapy development, robust in vitro models are needed. Extrusion- light-based bioprinting offer precise fabrication of tissue-like constructs, but creating bioinks that support cell function remains difficult. Here, we report a novel bioink which taurine is first methacrylated—substituting its –NH 2 groups to afford methacrylate (TMA)—enabling covalent integration into gelatin methacryloyl (GelMA) networks. We systematically compared GelMA-Taur (physical blend) versus GelMA-TMA (covalent) hydrogels, assessing mechanical stiffness, swelling behavior, photocrosslinking kinetics. Incorporating TMA yielded tighter crosslinking control, minimized overcure DLP-printed features, improved shape fidelity. SEM revealed finer pore structures homogeneous distribution, release assays confirmed prolonged retention rapidly leaching taurine. Photopatterning 3D printing complex geometries demonstrated excellent printability the bioink. Finally, C2C12 myoblasts encapsulated scaffolds exhibited accelerated early differentiation, higher myosin heavy chain expression, more extensive myotube formation than controls. Together, these results establish as printable, mechanically tunable, biologically active platform for engineering skeletal tissue modeling regenerative applications.

Language: Английский

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Nanoarchitectonics in colloidal hydrogels: Design and applications in the environmental and biomedical fields

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 342, P. 103529 - 103529

Published: April 30, 2025

Language: Английский

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Beta‐glucan modification and incorporation of peptide for infected wound healing applications

Polymer Engineering and Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Hydrogel dressings, known for their breathability and hygroscopic properties, have garnered significant attention in the field of bioactive wound care. Among them, hydrogels composed polysaccharides peptides offer superior biocompatibility, intrinsic antibacterial ability to mimic extracellular matrix. In this study, we developed hybrid hydrogels, BAA/C 8 G 2 , BAA/G 3 BAA/c(KW), by crosslinking immunomodulatory β‐glucan derivatives with antimicrobial via enamine bonds. These exhibited enhanced mechanical strength compared those crosslinked oxidized through imine bonding, alongside pH responsiveness controlled drug release behavior. The demonstrate broad‐spectrum activity against both Gram‐positive Gram‐negative bacteria, including methicillin‐resistant Staphylococcus aureus (MRSA), maintain sustained inhibition Escherichia coli over 10 days. Furthermore, they displayed excellent vitro biocompatibility effectively promoted fibroblast cell migration. results highlight potential enamine‐linked polysaccharide–peptide as promising candidates bacterial‐infected treatment. Highlights Acetoacetyl AMPs dynamic BAA‐peptide demonstrated improved properties. pH‐responsive bonds enabled AMPs. activity. are biocompatible promote

Language: Английский

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A drug-loaded nano chitosan/hyaluronic acid hydrogel system as a cartilage tissue engineering scaffold for drug delivery

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137314 - 137314

Published: Nov. 6, 2024

Language: Английский

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