Self-assembling peptides: Perspectives regarding biotechnological applications and vaccine development DOI Creative Commons
César Reyes, Manuel A. Patarroyo

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 259, P. 128944 - 128944

Published: Dec. 23, 2023

Self-assembly involves a set of molecules spontaneously interacting in highly coordinated and dynamic manner to form specific supramolecular structure having new clearly defined properties. Many examples this occur nature many more came from research laboratories, with their number increasing every day via ongoing concerning complex biomolecules the possibility harnessing it when developing applications. As phenomenon, self-assembly has been described on very different types (biomolecules including), so review focuses what is known about peptide self-assembly, its origins, forces behind it, how properties resulting material can be tuned relation experimental considerations, some biotechnological applications (in which main protagonists are sequences capable self-assembly) yet regarding development.

Language: Английский

Research Progress in Hydrogels for Cartilage Organoids DOI

Xiaolong Li,

Shihao Sheng, Guangfeng Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 21, 2024

The repair and regeneration of cartilage has always been a hot topic in medical research. Cartilage organoids (CORGs) are special tissue created using engineering techniques outside the body. These engineered tissues provide models that simulate complex biological functions cartilage, opening new possibilities for regenerative medicine treatment strategies. However, it is crucial to establish suitable matrix scaffolds cultivation CORGs. In recent years, utilizing hydrogel culture stem cells induce their differentiation into chondrocytes emerged as promising method vitro construction this review, methods establishing CORGs summarized an overview advantages limitations matrigel such provided. Furthermore, importance ECM alternative substitutes Matrigel, alginate, peptides, silk fibroin, DNA derivatives discussed, pros cons these hydrogels outlined. Finally, challenges future directions research discussed. It hoped article provides valuable references design development

Language: Английский

Citations

29
A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly DOI
Si‐Yong Qin, Jiaqi Feng, Yin‐Jia Cheng

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 502, P. 215600 - 215600

Published: Dec. 14, 2023

Language: Английский

Citations

38
Emerging frontiers in drug delivery with special focus on novel techniques for targeted therapies DOI Open Access
Ling Yu,

Shengmao Liu,

Shengnan Jia

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115049 - 115049

Published: June 25, 2023

The management and treatment of disease are achieved via the use pharmacologically active substances or drugs. Drugs do not, however, have an intrinsic ability to be effective; rather, how well they work depends on administered supplied. Treatment a variety biological illnesses, such as autoimmune disorders, cancer, bacterial infections, requires effective drug delivery. Drug absorption, distribution, metabolism, duration therapeutic impact, pharmacokinetics, excretion, toxicity can all impacted by administration. Improved chemistry materials required for delivery concentration novel treatments specified targets within body, necessary time. This requirement is accompanied development new therapeutics. Formulating medication DDS promising strategy directly addressing numerous typical barriers adherence, frequent dosage, side effects, delayed beginning action. In current review, we give compendium controlled release subsequently highlight some newest developments in realm, with particular emphasis cutting-edge methods targeted therapy. each instance, outline obstacles efficient administration chemical material that allowing sector overcome these positive clinical impact.

Language: Английский

Citations

27
Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies DOI Creative Commons
Yubo Wang, Lu Zhang,

Chen Liu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 240 - 240

Published: Feb. 6, 2024

Effective drug delivery is essential for cancer treatment. Drug systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of Peptides play a significant role various biological physiological functions offer high design flexibility, excellent biocompatibility, adjustable morphology, biodegradability, making them promising candidates delivery. This paper reviews peptide-mediated focusing on self-assembled peptides peptide–drug conjugates. It discusses mechanisms structural control peptides, varieties roles conjugates, strategies augment peptide stability. The review concludes by addressing challenges future directions.

Language: Английский

Citations

11
Injectable Hydrogels for Nervous Tissue Repair—A Brief Review DOI Creative Commons

Gladys Arline Politrón-Zepeda,

Gabriela Fletes-Vargas, Rogelio Rodríguez‐Rodríguez

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 190 - 190

Published: March 9, 2024

The repair of nervous tissue is a critical research field in engineering because the degenerative process injured system. In this review, we summarize progress injectable hydrogels using vitro and vivo studies for regeneration tissue. Traditional treatments have not been favorable patients, as they are invasive inefficient; therefore, promising treatment damaged This review will contribute to better understanding potential scaffolds drug delivery system neural applications.

Language: Английский

Citations

10
Gasotransmitter delivery for bone diseases and regeneration DOI Open Access

Yaoyao Xu,

Yanyue Li,

Ang Gao

et al.

The Innovation Life, Journal Year: 2023, Volume and Issue: 1(1), P. 100015 - 100015

Published: Jan. 1, 2023

<p>Endogenous gaseous signaling molecules, nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H<sub>2</sub>S), collectively called gasotransmitters, regulate various physiological pathophysiological processes. Thus, they offer significant advantages over traditional small-molecule drugs in treating bone diseases. However, their clinical use is limited by nature, extensive reactivity, short half-life. Also, these gasotransmitters behave as a double-edged sword, providing therapeutic effects at concentrates while exhibiting acute toxicity high concentrations. Therefore, controlled, sustained, even targeted delivery of highly desirable. In this review, we emphasize recent advances gasotransmitter materials, including the gas-releasing molecules platforms. We further focus on application diseases, implant-associate infection, immunomodulation, regeneration, osteoporosis, arthritis, aiming to provide references for development novel strategies diseases.</p>

Language: Английский

Citations

22
Recent research of peptide-based hydrogel in nervous regeneration DOI

Chunmei Xie,

Yueyang Chen,

Lang Wang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 40, P. 503 - 523

Published: June 29, 2024

Language: Английский

Citations

8
Harnessing the Potential of Self‐Assembled Peptide Hydrogels for Neural Regeneration and Tissue Engineering DOI
Haniyeh Najafi, Ghazal Farahavar, Mahboobeh Jafari

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 24(6)

Published: March 28, 2024

Abstract Spinal cord injury, traumatic brain and neurosurgery procedures usually lead to neural tissue damage. Self‐assembled peptide (SAP) hydrogels, a type of innovative hierarchical nanofiber‐forming sequences serving as hydrogelators, have emerged promising solution for repairing defects promoting regeneration. SAPs possess numerous features, such adaptable morphologies, biocompatibility, injectability, tunable mechanical stability, mimicking the native extracellular matrix. This review explores capacity cell regeneration examines critical aspects in neuroregeneration, including their biochemical composition, topology, behavior, conductivity, degradability. Additionally, it delves into latest strategies involving central or peripheral engineering. Finally, prospects SAP hydrogel design development realm neuroregeneration are discussed.

Language: Английский

Citations

5
Functionalized hydrogels as smart gene delivery systems to treat musculoskeletal disorders DOI Creative Commons

Mohammadsaeid Enayati,

Wei Liu, Henning Madry

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 331, P. 103232 - 103232

Published: June 14, 2024

Despite critical advances in regenerative medicine, the generation of definitive, reliable treatments for musculoskeletal diseases remains challenging. Gene therapy based on delivery therapeutic genetic sequences has strong value to offer effective, durable options decisively manage such disorders. Furthermore, scaffold-mediated gene provides powerful alternatives overcome hurdles associated with classical therapy, allowing spatiotemporal candidate genes sites injury. Among many scaffolds research, hydrogels raised increasing attention addition other potent systems (solid, hybrid scaffolds) due their versatility and competence as drug cell carriers tissue engineering wound dressing. Attractive functionalities include injectability, stimuli-responsiveness, self-healing, nanocomposition that may further allow upgrade them "intelligently" efficient mechanically platforms, rather than just inert vehicles. Such functionalized also be tuned successfully transfer a minimally invasive manner order protect cargos long-term effects. In light features, this review focuses demonstrates treatment disorders using procedures, from principles hydrogel functionalization methods applications hydrogel-mediated disorders, while remaining challenges are being discussed perspective translation patients. offering Scaffold-mediated therapy. attention. Functionalities including tune This introduces disorder

Language: Английский

Citations

4
Techno-Functional Properties and Potential Applications of Peptides from Agro-Industrial Residues DOI Creative Commons

Chaichawin Chavapradit,

Wonnop Visessanguan,

Suwan Panjanapongchai

et al.

JOURNAL OF RENEWABLE MATERIALS, Journal Year: 2025, Volume and Issue: 0(0), P. 1 - 10

Published: Jan. 1, 2025

The growing population and industrialization have led to significant production in agro-industrial sectors, resulting large amounts of residues often left untreated, posing potential environmental issues.Therefore, finding effective ways utilize these bio-based is crucial.One promising approach use low-or no-value wastes as raw materials for producing renewable biomaterials, including proteins peptides.Research has extensively explored peptide extraction using plant animal-based residue.Due lower processing costs beneficial bioactive properties, peptides derived from waste could replace synthetic those extracted food sources.The isolation, purification, analysis processes are thoroughly examined optimize their ensure purity efficacy.These peptides' properties mechanisms being analyzed applications the biomedical field.Additionally, medical fields, such drug delivery systems, tissue engineering, bioprinting, discussed.

Language: Английский

Citations

0