Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3849 - 3849

Published: March 29, 2024

This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on treatment skin wounds. Regenerative hydrogels, composed mainly water-absorbing polymers, have garnered attention in wound healing, particularly for Their unique properties make them well suited tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist environment optimal facilitating cell migration, proliferation. Biocompatibility is key feature, minimizing adverse reactions promoting natural healing process. Acting as supportive scaffold growth, mimic extracellular matrix, aiding attachment proliferation cells like fibroblasts keratinocytes. Engineered controlled drug release, enhance by angiogenesis, reducing inflammation, preventing infection. The demonstrated acceleration process, beneficial chronic or impaired wounds, adds to appeal. Easy application conformity various shapes practical, including irregular challenging areas. Scar minimization through regeneration crucial, especially cosmetic functional regions. Hydrogels contribute pain management protective barrier, friction, fostering soothing environment. Some with inherent antimicrobial properties, aid infection prevention, which crucial aspect successful healing. flexibility ability conform contours ensure contact, enhancing overall effectiveness. In summary, present promising approach improving outcomes across diverse clinical scenarios. provides comprehensive analysis benefits, mechanisms, challenges associated use this review, authors likely delve into rational design principles efficacy performance Through an exploration methodologies approaches, paper poised highlight how these been instrumental refining potentially revolutionizing therapeutic potential addressing By synthesizing current knowledge highlighting avenues future research, aims advancement medicine ultimately improve patients

Language: Английский

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Research progress of injectable hydrogels in the treatment of bone tissue diseases

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155139 - 155139

Published: Aug. 24, 2024

Language: Английский

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Hydrogels for Neural Regeneration: Exploring New Horizons

Materials, Journal Year: 2024, Volume and Issue: 17(14), P. 3472 - 3472

Published: July 13, 2024

Nerve injury can significantly impair motor, sensory, and autonomic functions. Understanding nerve degeneration, particularly Wallerian the mechanisms of regeneration is crucial for developing effective treatments. This manuscript reviews use advanced hydrogels that have been researched to enhance regeneration. Hydrogels, due their biocompatibility, tunable properties, ability create a supportive microenvironment, are being explored effectiveness in repair. Various types hydrogels, such as chitosan-, alginate-, collagen-, hyaluronic acid-, peptide-based discussed roles promoting axonal growth, functional recovery, myelination. Advanced formulations incorporating growth factors, bioactive molecules, stem cells show significant promise overcoming limitations traditional therapies. Despite these advancements, challenges achieving robust reliable remain, necessitating ongoing research optimize hydrogel-based interventions neural

Language: Английский

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Hydrogel-Based Therapies for Ischemic and Hemorrhagic Stroke: A Comprehensive Review

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 476 - 476

Published: July 18, 2024

Stroke remains the second leading cause of death and a major disability worldwide, significantly impacting individuals, families, healthcare systems. This neurological emergency can be triggered by ischemic events, including small vessel arteriolosclerosis, cardioembolism, large artery atherothromboembolism, as well hemorrhagic incidents resulting from macrovascular lesions, venous sinus thrombosis, or vascular malformations, to significant neuronal damage. The resultant motor impairment, cognitive dysfunction, emotional disturbances underscore urgent need for effective therapeutic interventions. Recent advancements in biomaterials, particularly hydrogels, offer promising new avenues stroke management. Hydrogels, composed three-dimensional networks hydrophilic polymers, are notable their ability absorb retain substantial amounts water. Commonly used polymers hydrogel formulations include natural like alginate, chitosan, collagen, synthetic such polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyacrylamide. Their customizable characteristics—such porosity, swelling behavior, mechanical strength, degradation rates—make hydrogels ideal biomedical applications, drug delivery, cell tissue engineering, controlled release agents. review comprehensively explores hydrogel-based approaches both therapy, elucidating mechanisms which provide neuroprotection. It covers application delivery systems, role reducing inflammation secondary injury, potential support neurogenesis angiogenesis. also discusses current technology challenges translating these innovations research into clinical practice. Additionally, it emphasizes limited number trials utilizing therapies addresses associated limitations constraints, underscoring further this field.

Language: Английский

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Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 52 - 52

Published: Jan. 9, 2025

Carpal Tunnel Syndrome (CTS) is a prevalent neuropathic disorder caused by chronic compression of the median nerve, leading to sensory and motor impairments. Conventional treatments, such as corticosteroid injections, wrist splinting, surgical decompression, often fail provide adequate outcomes for or recurrent cases, emphasizing need innovative therapies. Hydrogels, highly biocompatible three-dimensional biomaterials with customizable properties, hold significant potential CTS management. Their ability mimic extracellular matrix facilitates localized drug delivery, anti-adhesion barrier formation, tissue regeneration. Advances in hydrogel engineering have introduced stimuli-responsive systems tailored biomechanical environment carpal tunnel, enabling sustained therapeutic release improved integration. Despite these promising developments, applications remain underexplored. Key challenges include absence CTS-specific preclinical models rigorous clinical validation. Addressing gaps could unlock full hydrogel-based interventions, which offer minimally invasive, solutions that improve long-term reduce recurrence rates. This review highlights hydrogels transformative approach therapy, advocating continued research address translational barriers. These innovations redefine treatment landscape, significantly enhancing patient care quality life.

Language: Английский

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Nanomedicines for treatment of full-thickness wound

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 417 - 438

Published: Jan. 1, 2025

Language: Английский

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Modern advances in spinal cord regeneration: hydrogel combined with neural stem cells

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Severe spinal cord injuries (SCI) lead to loss of functional activity the body below injury site, affect a person’s ability self-care and have direct impact on performance. Due structural features role in body, consequences SCI cannot be completely overcome at expense endogenous regenerative potential and, developing over time, severe complications years after injury. Thus, primary task this type treatment is create artificial conditions for growth damaged nerve fibers through area SCI. Solving problem possible using tissue neuroengineering involving technology replacing natural environment with synthetic matrices (for example, hydrogels) combination stem cells, particular, neural/progenitor cells (NSPCs). This approach can provide maximum stimulation support axons neurons their myelination. In review, we consider currently available options improving condition (use NSC transplantation or/and replacement matrix, specifically hydrogel). We emphasise expediency effectiveness hydrogel matrix + NSCs complex system used reconstruction Since such (a engineering cell therapy), our opinion, allows not only creation supporting regeneration or mechanical cord, but also strengthen regeneration, prevent spread inflammatory process, promote restoration lost reflex, motor sensory functions injured cord.

Language: Английский

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Physical chitosan hydrogels loaded with TiO2 nanoparticles/resveratrol hydroalcoholic extract: Hemocompatibility, swelling, microstructural, and EDX mapping analysis

Materials Letters, Journal Year: 2024, Volume and Issue: 374, P. 137180 - 137180

Published: Aug. 10, 2024

Language: Английский

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Marine biopolymers in drug delivery applications

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 639 - 676

Published: Oct. 4, 2024

Language: Английский

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A Comprehensive Review on the Utilization of Biomaterials for Bio-Based Hydrogel in Therapeutic Applications

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

A bio-based hydrogel is a complex compound that consists of natural biomaterials and widely applied for various therapeutic purposes. The modification from traditional to reformulated hydrogels has gained place at biomedical field due the growth benefits such as drug delivery, tissue engineering, regenerative medicine. Moreover, increasing global demand resulted in worldwide shortage mass formulations raised environmental awareness. By using instead synthetic ones, these minimize their negative effects on environment while simultaneously maximizing successful execution product. However, mechanisms governing degradation bioactivity hydrogels, which dictate release profiles, stability, effectiveness, are not yet comprehensively understood. Therefore, by analyzing recent progress ongoing challenges, this review will reveal how advanced quietly transforming future healthcare offering novel solutions pressing health problems.

Language: Английский

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