Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157852 - 157852
Published: Nov. 1, 2024
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 1, 2025
Language: Английский
Citations
3
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 15, 2024
The tumour microenvironment represents a novel frontier in oncological research. Over the past decade, accumulating evidence has underscored importance of (TME), including cells, stromal immune and various secreted factors, which collectively influence growth, invasion, responses to therapeutic agents. Immune cells within TME are now widely acknowledged play pivotal roles development treatment. While some perspectives have posited that facilitate progression confer resistance interventions, contrasting conclusions also exist. Affirmative negative appear be context dependent, unified consensus yet reached. burgeoning body research on relationship between gut microbiota tumours recent years led growing understanding. Most studies indicated specific components microbiota, such as unique bacterial communities or secretory diverse regulating TME, thereby influencing prognosis outcomes cancer treatments. A detailed understanding these factors could provide insights into therapy. In this study, we aimed synthesise information interactions providing an in-depth exploration potential guiding implications for future therapies.
Language: Английский
Citations
5
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Micro- and nanoplastics, particularly those derived from food-contact materials like polyethylene terephthalate (PET), can damage gut barriers, making the gastrointestinal system more vulnerable to inflammation infections. Here, a probiotic-based drug delivery (EcNT@L) is devised mitigate nanoplastics-induced barrier dysfunction by modulating immunity microbiota. Escherichia coli Nissle 1917 (EcN) genetically engineered produce transforming growth factor-β (TGF-β) then modified with an Eudragit L100-55 coating. This probiotic acts as in vivo "drug factory", exerting anti-inflammatory immune-regulatory effects, improved retention bioavailability tract. EcNT@L effectively protects Caco-2 cells infections induced nano PET, primarily activating NF-κB signaling pathway. Besides, demonstrates superior therapeutic efficacy treating infection caused combined presence of PET Salmonella, outperforming commercial antibiotics due its ability modulate immune responses study highlights potential systems addressing dysfunctions, offering promising strategy for mitigating environmental impact micro- nanoplastics.
Language: Английский
Citations
0
Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23
Published: April 11, 2025
Probiotics offer substantial health benefits, leading to their increased consumption in various food products. The viability of probiotics is a critical factor that influences the nutritional and therapeutic efficacy these foods. However, as often lose during production oral administration, effective preservation encapsulation technologies are needed overcome this challenge. This review elucidates diverse sources incorporation strategies probiotics, while systematically analyzing effects water transformation (ice front velocity, glass transition temperature, collapse temperature), processing conditions (food matrix, dissolved oxygen), gastrointestinal challenges (gastric fluid, digestive enzymes, bile salts) on probiotic viability. Effective strengthen encompass three primary domains: fermentation processes, techniques, methods. Specifically, include meticulous control (nitrogen sources, lipids, carbon sources), pre-stress treatments (pre-cooling, heat shock, NaCl stress, acid stress), optimized lyoprotectant selection (carbohydrates, proteins, polyols), synergistic freeze-drying (infrared technology, spray drying, microwave), bulk approaches (polysaccharide or protein-based microencapsulation), single-cell methods (self-assembly surface functionalization). Despite advancements, targeting specific matrices remains challenging, necessitating further research enhance
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 10, 2025
The fundamental step in microbiological detection is the preparation of culture medium. reliability and accuracy assay heavily relies on this step. Currently China, most recognized standard method for such medium evaluation ISO 11133-2014. However, requires highly complicated biosafety management, detailed strains record-keeping substantial working time. Bacterial tablet considered to be a novel strategy bacteria evaluation. filter membrane as carrier ensures uniform cell dispersion, forming singular colony that can facilitate counting. We examined viability storage durability vacuum freeze-dried bacterial tablets using utilized results evaluate found recipe GBSS (Glycerinum, Brain Heart Infusion, Sucrose, Sodium Glutamate) showed highest survival rate Escherichia coli freeze-drying. As qualified medium, productivity target bacterium should greater than 0.7. A comparison with 11133-2014 quantitative sensitivity specificity were 94.1% 88.9% respectively. suggested had high conformity when compared (χ 2 = 0.25, p > 0.05; Kappa 0.75). Hence, freeze-drying an integral part preservation related biological products. In conclusion, we have developed effective disposable product estimating efficiency
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 17, 2025
Intratumoral microbiota has been found to be a crucial component of hepatocellular carcinoma (HCC). Due insufficient recognition, technical limitations, and low biomass intratumoral microbiota, it is poorly understood. exhibit significant diversity in HCC tissues. It involved the development through several mechanisms, such as remodeling immunosuppressive microenvironment, metabolic reprogramming, genetic alterations. Moreover, associated with metastasis cells. Herein, we reviewed history applied biotechnology depict signatures investigated potential sources assessed their functions, heterogeneity. Furthermore, this review, summarized therapeutics that can used treatment proposed future perspectives for research field.
Language: Английский
Citations
0
Langmuir, Journal Year: 2025, Volume and Issue: unknown
Published: April 18, 2025
Probiotic oral delivery is challenged by harsh gastrointestinal conditions and environmental stressors in the body. This study presents construction of durable nanoshells composed an Fe3+-phytic acid metal-organic complex around individual probiotic cells, providing exceptional cytoprotective properties, single-cell nanoencapsulation. Nanoencapsulated Levilactobacillus brevis maintains high viability under simulated gastric fluid antibiotic tetracycline. The provide effective platform for improving functionality probiotics therapeutic nutritional applications.
Language: Английский
Citations
0
Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(3)
Published: May 1, 2025
Abstract Quercetin (Qu), a naturally occurring flavonoid abundant in various fruits, vegetables, and grains, has garnered significant attention due to its potent antioxidant properties wide range of functional activities, including anti‐inflammatory, antibacterial, anti‐tumor, neuroprotective effects. These attributes make Qu promising candidate for extending the shelf‐life food, enhancing human health preventing chronic diseases. However, practical application faces challenges such as poor stability during food processing storage, susceptibility environmental factors, low water solubility, bioavailability, which limit effective potential. To address these challenges, innovative Qu‐based delivery systems are being developed, protect from degradation improve absorption gastrointestinal tract, maximizing efficacy. Additionally, combinations explored enhance activity utilization by integrating their advantages, increasing effectiveness. This review comprehensively summarizes associated with biomedicine applications reviews advanced strategies overcome obstacles. It systematically introduces structure characteristics derivatives, discusses instability processing, digestion, highlights factors contributing degradation. By reviewing recent advances systems, this provides insights into how technologies can stability, targeted efficacy Qu, presenting current future development prospects more safety health‐promoting applications.
Language: Английский
Citations
0
Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105076 - 105076
Published: May 1, 2025
Language: Английский
Citations
0