Inclisiran in patients with acute ischemic stroke: first data DOI Creative Commons
M. S. Cherepyansky, G. M. Ponomareva, I. B. Skiba

et al.

Kardiologiia, Journal Year: 2023, Volume and Issue: 63(10), P. 39 - 46

Published: Nov. 8, 2023

Aim. To evaluate the effect of inclisiran therapy on parameters lipid metabolism in hospitalized patients with acute ischemic stroke. Material and methods. A prospective, observational, non-randomized study was performed. The included 12 stroke prescribed a combination lipid-lowering (284 mg as single dose). At 15 days after start therapy, changes blood composition were assessed. For quantitative variables, median, maximum minimum values determined. significance differences between related samples variables assessed using Mann-Whitney test. Results. Before total cholesterol (TC) 7.33 mmol/l low-density lipoprotein C (LDL-C) 5.23 mmol/l. TC significantly decreased by 52.1 % LDL-C 71.1 %. proportion who reached goal 66.7 There no adverse events considered investigators to be therapy. Conclusion. strategy early administration (or its statin) allows safe achievement significant reduction already

Language: Английский

Potential Correlation Between Hematological Parameters and Palpitation in Outpatients With COVID‐19: A Retrospective Study DOI Creative Commons
Lei Zhang, Ting Chen, Ling Wei

et al.

Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Research on heart injury caused by COVID-19 is limited to large observational and retrospective cohort studies using imaging or pathological data. Reported changes in the levels of myocardial markers severe diseases have been limited, with few mild infections. The effects cardiac function marker not yet reported. We analyzed data from outpatient blood samples collected at Beijing Anzhen Hospital during 2022 outbreak used same periods 2020 2021 as controls, focusing routine tests, coagulation, markers, other indices patients palpitations. number palpitations increased 4.87-fold mass 2022. damage did show any symptom-related increases but decreased within normal range. proportion whose D-dimer fibrinogen/fibrin degradation product (FDP) values exceeded reference ranges increased, numbers neutrophils, monocytes, platelets. In this analysis, we found little change COVID-19. COVID-19, attention should be diverted detecting coagulation test results, improve circulation prevent thrombosis.

Language: Английский

Citations

0
Cardiovascular Symposium on Perspectives in Long COVID DOI Creative Commons

Robert S. Dieter,

Prakasha Kempaiah, Elizabeth G. Dieter

et al.

Clinical and Applied Thrombosis/Hemostasis, Journal Year: 2025, Volume and Issue: 31

Published: Jan. 1, 2025

Significant progress has been made in treating Coronavirus disease (COVID) – an infectious caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ominous turn pandemic is evolving public health crisis emanating from persistent SARS-CoV-2 infection and its associated long-term impact. Long COVID or post–COVID describes protean symptoms that persist at least 3 months after onset of illness last for individuals with a history confirmed infection. become concern. Millions infected are now facing chronic multi-organ failures, including neuropsychiatric, cardiovascular, pulmonary, kidney complications. In general, cause long unclear but factors such as prolonged activation immune responses, viral persistence triggering transcription dysregulation genes normal thrombotic may play role cardiovascular Although inflammatory biomarkers reported other disorders, it remains whether similar manifestations following COVID. Medications sulodexide directed glycocalyx coagulation have demonstrated benefits smaller studies. Here, we describe outcomes symposium on underlying mechanisms

Language: Английский

Citations

0
Impact of Pre-Existing Disability on Long-Term Health Care Use Following Hospitalization for COVID-19: A Population-Based Cohort Study DOI Creative Commons
Hilary K. Brown, Thérèse A. Stukel, Hannah Chung

et al.

Journal of General Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract Background Emerging evidence shows the lasting impact of SARS-CoV-2 infection on health care use and needs. Policy-makers require data population-level service to understand patient needs system impacts following hospitalization for COVID-19. Objective To compare within 12 months COVID-19 among people with without pre-existing disabilities, determine extent which such is related disability other risk factors. Design Population-based cohort study, Ontario, Canada. Participants Adults disabilities hospitalized COVID-19, 01/25/2020–02/28/2022. Main Measures We used Poisson regression model adjusted rate ratios (aRR) ambulatory visits, diagnostic testing, emergency department (ED) hospital admissions, palliative visits 1-year post-discharge, comparing patients disabilities. Models were sequentially sociodemographic factors, comorbidities, prior use. The importance each set covariates in its ability explain observed associations was determined by calculating relative changes parameter coefficients after sequential risk-adjustment. Key Results included 25,320 15,953 without. In year had higher rates tests, ED visits. A significant proportion these explained However, associated remained elevated, even adjustment, (aRR 1.09, 95% CI 1.08, 1.10), tests 1.14, 1.12, 1.16), 1.25, 1.21, 1.29), admissions 1.16, 1.29). Conclusions These findings support need develop evaluate models post-COVID-19 condition that address

Language: Английский

Citations

0
Long COVID management: a mini review of current recommendations and underutilized modalities DOI Creative Commons

Tiffany K. Dietz,

Kirsten N. Brondstater

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: June 14, 2024

Long COVID is a condition that develops in subset of patients after COVID-19 infection comprising symptoms varying severity encompassing multiple organ systems. Currently, long without consensus on formal definition, identifiable biomarkers, and validated treatment. expected to be long-term chronic for associated with suffering incapacity. There an urgent need clear management guidelines the primary care provider, who essential bridging gap more specialized improve quality life functionality their living COVID. The purpose this mini review provide providers latest highlights from existing literature regarding most common current recommendations. This also underutilized interventions stellate ganglion blocks low-dose naltrexone, both well-established safety profiles demonstrated some COVID, encourages prompt referral interventional pain management.

Language: Английский

Citations

3
Prescripción de ejercicio en condición pos-COVID. Un reto en Atención Primaria DOI
M.M. Yagüe Sebastián,

Sevilla Quintanilla

Medicina de Familia SEMERGEN, Journal Year: 2024, Volume and Issue: 50(4), P. 102190 - 102190

Published: Feb. 2, 2024

Language: Английский

Citations

2
Cardiovascular abnormalities of long-COVID syndrome: Pathogenic basis and potential strategy for treatment and rehabilitation DOI Creative Commons

Kainuo Wu,

Jonathan Van Name, Lei Xi

et al.

Sports Medicine and Health Science, Journal Year: 2024, Volume and Issue: 6(3), P. 221 - 231

Published: March 24, 2024

Cardiac injury and sustained cardiovascular abnormalities in long-COVID syndrome, i.e. post-acute sequelae of coronavirus disease 2019 (COVID-19) have emerged as a debilitating health burden that has posed challenges for management pre-existing conditions other associated chronic comorbidities the most vulnerable group patients recovered from acute COVID-19. A clear evidence-based guideline treating cardiac issues syndrome is still lacking. In this review, we summarized common symptoms reported months after COVID-19 illness further evaluated possible pathogenic factors underlying pathophysiology process long-COVID. The mechanistic understanding how Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) damages heart vasculatures critical developing targeted therapy preventive measures limiting viral attacks. Despite currently available therapeutic interventions, considerable portion severe reduced functional reserve due to deconditioning. Therefore, rigorous comprehensive rehabilitation program with individualized exercise protocols would be instrumental regain physical fitness levels comparable their pre-illness baseline.

Language: Английский

Citations

2
Imaging Acute and Chronic Cardiac Complications of COVID-19 and after COVID-19 Vaccination DOI
Felipe Sánchez Tijmes, Constantin Marschner, João Matos

et al.

Radiographics, Journal Year: 2023, Volume and Issue: 43(9)

Published: Aug. 24, 2023

COVID-19 is associated with acute and longer-term cardiovascular manifestations including myocardial injury, myopericarditis, stress-induced cardiomyopathy, infarction, thromboembolic disease. Although the morbidity mortality related to have decreased substantially, there growing concern about effects of disease postacute sequelae. Myocarditis has also been reported after messenger ribonucleic acid (mRNA)-based vaccination, highest risk among adolescent boys young adult men. Noninvasive imaging cardiac MRI a key role in identifying presence disease, evaluating for potential mechanisms stratifying future adverse events, potentially guiding treatment patients suspected injury vaccination. Patterns identified at include myocarditis pericarditis, ischemia, infarction. Myocardial edema late gadolinium enhancement described months initial infection minority persistent symptoms COVID-19. In receiving most common pattern subepicardial basal inferolateral wall, tend milder abnormalities compared those from other causes myocarditis. This article describes multimodality findings an mRNA-based ©RSNA, 2023 Online supplemental material available this article. Quiz questions are through Learning Center.

Language: Английский

Citations

4
The negative effects of long COVID-19 on cardiovascular health and implications for the presurgical examination DOI Creative Commons

Hannah L. Stimart,

Brittany Hipkins

Journal of Osteopathic Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

In 2019, emergence of the novel and communicable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection took scientific communities by surprise imposed significant burden on healthcare systems globally. Although advent this disease piqued interest academic centers, systems, general public, there is still much yet to be elucidated regarding epidemiology, pathophysiology, long-term impacts 2019 (COVID-19). It has been established that long COVID-19 can impact multiple organ including cardiovascular system, unfavorably. pathophysiology damage not well understood, adverse sequelae may range from chest pain arrhythmias heart failure (HF), myocardial infarction, or sudden cardiac death. For any postacute patient requiring a surgical procedure, potential for injury secondary must considered in preoperative examination.

Language: Английский

Citations

1
Treatments for Long COVID autonomic dysfunction: a scoping review DOI
Jonathan Treadwell, Jesse Wagner, James Reston

et al.

Clinical Autonomic Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Language: Английский

Citations

0
Return-to-work for People Living with Long COVID: A Scoping Review of Interventions and Recommendations DOI Creative Commons
Gagan Nagra, Victor E. Ezeugwu, Geoff P. Bostick

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

ABSTRACT Introduction Long COVID affects individuals’ labour market participation in many ways. While some cannot work at all, others may return to (RTW) a limited capacity. Determining what rehabilitation or related strategies are safe and effective for facilitating RTW is necessary. Objectives To synthesize evidence on interventions people living with identify ‘promising’ enhancing ability RTW. Methods We followed Arksey & O’Malley’s methodology the PRISMA extension scoping reviews. Five electronic bibliographic databases grey literature were searched. The included various study designs, such as randomized controlled trials (RCT), quasi-experimental observational studies. Two reviewers conducted screening data extraction, disagreements resolved through consensus. Intervention studies categorized promising (statistically significant outcomes ≥ 50% RTW), somewhat (20% < not (non-statistically 20% RTW). Results Eleven recommendations eleven intervention identified. Of studies, 6 cohort 3 1 RCT case report. Promising multimodal interdisciplinary work-focused (1 article), psychoeducation, pacing, breathing (2 articles), shifting focus from symptom monitoring optimizing functional enhanced external CounterPulsation (EECP) inflatable pressure improve blood flow article). Conclusion Many uncertainties remain regarding which optimal characteristics of these interventions.

Language: Английский

Citations

0