Reactive oxygen species in hypertension

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

Language: Английский

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Transient receptor potential melastatin 7 cation channel, magnesium and cell metabolism in vascular health and disease

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(2)

Published: Jan. 12, 2025

Abstract Preserving the balance of metabolic processes in endothelial cells (ECs) and vascular smooth muscle (VSMCs), is crucial for optimal function integrity. ECs are metabolically active depend on aerobic glycolysis to efficiently produce energy their essential functions, which include regulating tone. Impaired EC metabolism linked damage, increased permeability inflammation. Metabolic alterations VSMCs also contribute dysfunction atherosclerosis hypertension. Magnesium (Mg 2+ ) second most abundant intracellular divalent cation influences molecular that regulate function, including vasodilation, vasoconstriction, release vasoactive substances. Mg critically involved maintaining cellular homeostasis since it an cofactor ATP, nucleic acids hundreds enzymes processes. Low levels have been dysfunction, tone, inflammation arterial remodeling. Growing evidence indicates important role transient receptor potential melastatin‐subfamily member 7 (TRPM7) channel regulation VSMCs. In vasculature, TRPM7 deficiency leads impaired contraction, phenotypic switching VSMCs, fibrosis, characterize phenotype Here we provide a comprehensive overview TRPM7/Mg how VSMC such as glucose homeostasis, redox regulation, phosphoinositide signaling, mineral metabolism. The putative altered hypertension discussed.

Language: Английский

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Isolated Systolic Hypertension in Geriatrics

International Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 16(01), P. 29 - 53

Published: Jan. 1, 2025

Language: Английский

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Endothelium-independent vasorelaxant effects of Curcuma phaeocaulis essential oil and its representative compound isocurcumenol

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 341, P. 119366 - 119366

Published: Jan. 17, 2025

Language: Английский

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Recent advancements in the application of multi-elemental profiling and ionomics in cardiovascular diseases

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127616 - 127616

Published: Feb. 7, 2025

Language: Английский

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Long-term effects of PM2.5 and its components on incident hypertension among the middle-aged and elderly: a national cohort study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 11, 2025

The long-term health effects of fine particulate matter (PM2.5) on hypertension remain incomprehensive. We evaluated the relationship PM2.5 and its components with incidence in middle-aged elderly adults. utilised data from China Health Retirement Longitudinal Study collected between 2011 2018. obtained annual modelled dataset Tracking Air Pollution China, including black carbon (BC), sulphate (SO42-), organic (OM), ammonium (NH4+), nitrate (NO3-). Time-varying Cox models quantile g-computation were employed to explore associations. Exposure-response curves portrayed investigate potential non-linear effects. enrolled 7,032 individuals a mean age 57.14 (range: 45-95) years. Over 36,997 person-years follow-up (average time: 5.26 years), 3,119 suffered hypertension. With per interquartile range increment, hazard ratios 95% confidence intervals (CIs) (3.82 [95% CI: 3.48-4.18]), BC (4.17 3.54-4.92]), SO42- (4.24 3.50-5.12]), OM (3.76 3.14-4.50]), NH4+ (3.20 2.91-3.52]), NO3- (1.94 1.77-2.13]) discovered lag 1 year. And mixed effect was 18.0% 16.8%-19.2%], which mainly driven by (66.0%) (34.0%). Approximate J-shaped exposure-response relationships revealed. positive associations exposure adults aged ≥ 45 Controlling emissions components, especially SO42-, could alleviate burden

Language: Английский

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Exposure to specific polyfluoroalkyl chemicals is associated with cardiovascular disease in US adults: a population-based study

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 9, 2025

Polyfluoroalkyl chemicals (PFCs) present potential health risks due to their persistence and bioaccumulation. However, there is currently insufficient evidence regarding impact on cardiovascular disease (CVD). Consequently, it imperative investigate the correlation between PFCs CVD. The data was collected from National Health Nutrition Examination Survey in 2005-2012. Logistic regression models were employed assess association single PFC Generalized additive model (GAM) used for evaluating nonlinear relationships. Subgroup analyses conducted explore interaction effects. Bayesian kernel machine (BKMR) weighted quantile sum (WQS) evaluate joint effect of exposures In logistic regression, PFDE, MPAH, PFUA positively associated with GAM, a significant relationship MPAH analysis revealed gender race effects correlated CVD males but show no difference females. PFDE among non-Hispanic white individual. results BKMR indicated that mixed increased initially then weakened, showing an overall positive trend. WQS suggested PFDO contributed most effect. Our study showed serum levels PUFA found interact relation A general exists exposure CVD, being contributory PFC. provided important probing laid foundation further mechanism research.

Language: Английский

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Blood Pressure Trends, Demographic Data, Workload, and Lifestyle Factors Among Nurses in the Subcarpathian Region of Poland: A Cross-Sectional Observational Study

Medical Science Monitor, Journal Year: 2024, Volume and Issue: 30

Published: July 3, 2024

BACKGROUND Hypertension is one of the main modifiable risk factors linked to cardiovascular disease and its prevalence currently increasing in various age groups. This study aimed evaluate blood pressure, demographic data, workload, lifestyle nurses employed hospitals Subcarpathian region southeastern Poland. MATERIAL AND METHODS cross-sectional observational was conducted among 627 professionally active nurses. Certified devices were used for measurements: body mass analyzer (Tanita MC-980 PLUS MA), automated sphygmomanometer (Welch Allyn 4200B), stadiometer (Seca 213), tape measure 201). The frequency consumption specific product groups assessed using a survey method. Analysis R software (version 4.3.1) logistic regression examine variables affecting hypertension occurrence. RESULTS found that elevated pressure more prevalent than they self-report. Logistic analysis identified significant predictors hypertension, including (odds ratio; OR=1.061; OR=1.045), working 1 job (OR=1.579; OR=1.864), index (OR=1.152; OR=1.113). CONCLUSIONS Regular monitoring necessary early detection timely intervention hypertension. Enhancing nurses' awareness their own health will encourage proactive preventive measures. Implementing comprehensive education programs focused on latest advances prevention essential.

Language: Английский

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The Effect of Plasma Treatment on the Mechanical and Biological Properties of Polyurethane Artificial Blood Vessel

Materials, Journal Year: 2023, Volume and Issue: 16(22), P. 7231 - 7231

Published: Nov. 19, 2023

In recent years, the incidence of cardiovascular disease has increased annually, and demand for artificial blood vessels been increasing. Due to formation thrombosis stenosis after implantation, application many materials in human body inhibited. Therefore, choice surface modification process is very important. this paper, small-diameter polyurethane were prepared through electrospinning, their surfaces treated with plasma improve biological properties. The samples before treatment characterized by SEM, contact angle, XPS, tensile testing; meanwhile, cell compatibility evaluated. results show that there are no significant changes fiber morphology or diameter distribution on sample treatment. Plasma can increase proportion oxygen-containing functional groups its wettability, thereby increasing infiltration ability cells promoting proliferation. reduce risk hemolysis, does not cause platelet adhesion. etching effect plasma, mechanical properties decreased extension time, which should be used as a basis balance property vessels. But whole, positive significance improving comprehensive performance samples.

Language: Английский

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Impact of cotton dust, endotoxin exposure, and other occupational health risk due to indoor pollutants on textile industry workers in low and middle- income countries

Journal of Air Pollution and Health, Journal Year: 2024, Volume and Issue: unknown

Published: March 10, 2024

The textile industry consists of several units that engage different processes namely ginning, spinning, weaving, dyeing, printing, and other which required for converting raw cotton fiber into finished fabrics. Exposure to dust, endotoxin, chemicals, noise, musculoskeletal disorders causes health-related hazards workers. This review article aims study the health issues due various risk factors associated with working environment in detail its impacts on workers' health. also reports dust endotoxin concentrations indoor environments industries, as well discusses association between workplace exposure prevalence respiratory disorders. In this review, focus is given pollutants like Particulate Matter (PM), Carbon dioxide (CO2), monoxide (CO), Volatile Organic Compounds (VOCs), Formaldehyde (HCHO) effects human expands aspects influence comfort during hours occupational disorders, eyesight problems. addition, advanced technologies monitoring air quality control reduction current regulatory limits pollutants, suggestions enhance safety conditions sectors are pointed out. conclusion, stresses need regulate apply international standards sector prevent short- long-term illness.

Language: Английский

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