Association between oxidative balance score and cardiovascular diseases: mediating analysis of methylmalonic acid based on the NHANES database

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 11, 2024

To explore the association between oxidative balance score (OBS) and cardiovascular diseases (CVD) in patients with hypertension, further clarify mediating role of methylmalonic acid (MMA) relationship OBS CVD risk.

Language: Английский

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Alimentation-dependent prevalence: regional study

Hygiene and Sanitation, Journal Year: 2024, Volume and Issue: 103(11), P. 1398 - 1404

Published: Dec. 16, 2024

Introduction. It is widely known that suboptimal nutrition can trigger the mechanisms of development or progression alimentary-dependent diseases (ADD). Aim to study trend in morbidity adult population Republic Buryatia (RB). Materials and methods. The was conducted on basis for 2014–2023. RB comparison with data Far Eastern Federal District Russian Federation. assessment actual power supply carried out using software. Results. Comparison average ADD indices 2019–2023 compared 2014–2018 showed an increase by 1.23 times circulatory system 1.17 endocrine system. sigmal deviation method revealed prevalence exceeds regional level from 2.1 8.5% thyrotoxicosis, diabetes mellitus, including type II, obesity, federative 4.4 9.7% thyrotoxicosis. In diet, there a deficiency B vitamins, calcium, magnesium, potassium, sodium surplus. Limitations. results among region nutritional characteristics workers industrial center clearly do not prove causality formation these diseases. Conclusion. identified features require coordinated work interdisciplinary team experts entire community focused optimal nutrition.

Language: Английский

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Relationship between lipid levels, TyG, TyG-BMI index and hypertension in Tibetan population in Tibet, China based on restricted cubic spline model

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 27, 2024

The prevalence of hypertension among the Tibetan population in Tibet is higher than other regions China, and there a lack unified epidemiological surveys. This study aims to conduct standardized investigation assess current status population, as well explore dose–response relationship between cholesterol (TC), triglyceride glucose index (TyG), glucose-body mass (TyG-BMI), this population. From June 2020 July 2023, total 5042 Tibetans aged 18 80 years from three cities one region were randomly sampled for study. Logistic regression analysis models combined with restricted cubic splines used analyze LDL-C, TC, TyG, TyG-BMI index, HTN (1) Tibet, was 32.35%, which men slightly women. (2) Age, BMI, fasting blood (FBG), uric acid (UA), triglycerides (TG), homocysteine (Hcy), populations compared non-HTN (P < 0.05). (3) risk increased individuals borderline elevated second(Q2), third(Q3), fourth quartile groups(Q4) TyG third(Q3) TyG-BMI. gradually levels trend 0.001). (4) results spline showed nonlinear developing 0.001, P Nonlinear 0.05), linear > Higher are factors China. Effective prevention can be achieved by controlling lipid indices.

Language: Английский

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Stability Indicating Reverse Phase Ultra Performance Liquid Chromatography Method Development and Validation for Amiloride and Hydrochlorothiazide Tablet in the Presence of Degradation Products and Application to Green Analytical Principles

International Journal of Pharmaceutical Quality Assurance, Journal Year: 2023, Volume and Issue: 14(04), P. 1058 - 1066

Published: Dec. 25, 2023

Amiloride (AML) and hydrochlorothiazide (HCTZ) combination is used alone or with other medicines to treat high blood pressure (hypertension). The present article provides the development validation of an reverse phase ultra performance liquid chromatography (RP-UPLC) approach for quantification AML, HCTZ, related impurities in pharmaceutical dosage forms. analytical column separation Waters X bridge C18 3.5 μm (50 mm 4.6 mm). Used 0.1% formic acid ethanol as MP isocratic mode 0.3 mL/min flow rate 3 μL injection volume, at 254 nm detection UV 12 minutes total run time. samples were prepared specifically undergo forced degradation, which involved subjecting them hydrolysis, oxidation, thermal, photolytic conditions. technique underwent by principles set forth ICH Q2 guidelines. confirmed that method possesses specificity, linearity, ruggedness, robustness accuracy. methodology employed exhibited a linear relationship extending from 10 150% all impurities. recovery analysis was conducted throughout range concentrations, starting concentration. average value determined be within acceptable limits. evidence degradation findings verified study suggest nature subject under investigation stable. Hence, this might domains research quality control departments. Green chemistry tools are assess method’s greenness calculated using GAPI, AGREE ecological-scale found excellent green >75%.

Language: Английский

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Not for the Faint of Heart: Environmental Influences on Cardiovascular Health

Canadian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 39(9), P. 1163 - 1165

Published: Sept. 1, 2023

Language: Английский

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