Makara Journal of Science,
Journal Year:
2021,
Volume and Issue:
25(3)
Published: Sept. 29, 2021
The
emerging
technology
in
biomedical
engineering
requires
biocompatible
materials,
which
are
also
referred
to
as
biomaterials.
For
a
material
be
considered
biocompatible,
it
should
not
interact
with
human
tissues
harmful
way,
and
vice
versa.
Various
properties
of
such
mechanical
optical
properties,
have
for
different
applications.
One
the
most
popular
applications
biomaterials
is
contact
lenses.
Hydrogels,
specifically
poly(2-hydroxyethyl
methacrylate)
(PHEMA)
hydrogels,
among
ones
ophthalmologic
applications,
especially
soft
This
paper
reviews
use
PHEMA
hydrogels
one
important
possible
manufacturing
process
lens
addressed.
Many
studies
shown
that
possess
many
advantages
promising
development
prospects.
Cells,
Journal Year:
2021,
Volume and Issue:
10(9), P. 2302 - 2302
Published: Sept. 3, 2021
In
the
human
cornea,
regeneration
of
epithelium
is
regulated
by
stem
cell
reservoir
limbus,
which
marginal
region
cornea
representing
anatomical
and
functional
border
between
corneal
conjunctival
epithelium.
support
this
concept,
extensive
limbal
damage,
e.g.,
chemical
or
thermal
injury,
inflammation,
surgery,
may
induce
deficiency
(LSCD)
leading
to
vascularization
opacification
eventually
vision
loss.
These
acquired
forms
occur
uni-
bilaterally,
important
for
choice
treatment.
Moreover,
a
variety
inherited
diseases,
such
as
congenital
aniridia
dyskeratosis
congenita,
are
characterized
LSCD
typically
occurring
bilaterally.
Several
techniques
autologous
allogenic
transplantation
have
been
established.
The
limbus
can
be
restored
whole
grafts,
small
biopsies
ex
vivo-expanded
cells.
review,
physiology
epithelium,
pathophysiology
LSCD,
therapeutic
options
will
presented.
