The Influence of Microbiota on Breast Cancer: A Review

Cancers, Journal Year: 2024, Volume and Issue: 16(20), P. 3468 - 3468

Published: Oct. 13, 2024

Breast cancer remains one of the leading causes death among women worldwide, and recent research highlights its growing connection to alterations in microbiota. This review delves into intricate relationship between microbiotas breast cancer, exploring presence healthy tissue, changes during progression, considerable impact on both tumor microenvironment (TME) immune (TIME). We extensively analyze how microbiota influences growth, invasion, metastasis, resistance drugs, evasion system, with a special focus effects TIME. Furthermore, we investigate distinct microbial profiles associated four primary molecular subtypes examining tissues compares that adjacent normal tissues. Emerging studies suggest could serve as valuable diagnostic prognostic biomarkers, well targets for therapy. emphasizes urgent need further improve strategies prevention, diagnosis, treatment. By offering detailed examination microbiota's critical role this aims foster development novel microbiota-based approaches managing disease.

Language: Английский

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Pathogen-Induced Epigenetic Modifications in Cancers: Implications for Prevention, Detection and Treatment of Cancers in Africa

Cancers, Journal Year: 2021, Volume and Issue: 13(23), P. 6051 - 6051

Published: Dec. 1, 2021

Cancer is a major public health burden worldwide. Tumor formation caused by multiple intrinsic and extrinsic factors. Many reports have demonstrated positive correlation between the of infectious pathogens occurrence cancers. However, mechanistic link cancer development remains largely unclear subject to active investigations. Apart from somatic mutations that been widely linked with various cancers, an appreciable body knowledge points alterations host epigenetic patterns as key triggers for development. Several studies associated modifications. It therefore plausible assume induce carcinogenesis via alteration normal patterns. Thus, Africa its disproportionate threatened dramatic increase in pathogen-mediated To curb potential upsurge such better understanding role tropical epigenetics could substantially provide resources improve management among Africans. Therefore, this review discusses burden. In addition, we discuss mechanisms which cancers opportunities challenges pathogen-induced changes prevention, detection management.

Language: Английский

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Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 15531 - 15531

Published: Dec. 8, 2022

Purpose/Objective(s): Microbiome has been shown to affect tumorigenesis by promoting inflammation. However, the association between upper aerodigestive microbiome and head neck squamous cell carcinoma (HNSCC) is not well established. Hypoxia a modifiable factor associated with poor radiation response. Our study analyzed HNSCC tumor samples from The Cancer Genome Atlas (TCGA) investigate relationship different subsites, hypoxia, local composition. Results: A total of 357 patients were included [Oral cavity (OC) = 226, Oropharynx (OPx) 53, Larynx/Hypopharynx (LHPx) 78], which 12.8%, 71.7%, 10.3%, respectively, HPV positive. mean (SD) hypoxia scores 30.18 (11.10), 24.31 (14.13), 29.53 (12.61) in OC, OPx, LHPx tumors, higher values indicating greater hypoxia. score was significantly for OC tumors compared OPx (p 0.044) 0.002). There no significant correlation status. Pseudomonas sp. Actinomyces Sulfurimonas Filifactor, had strongest score. Materials/Methods: Tumor RNAseq TCGA processed, R package “tmesig” used calculate gene expression signature, including Buffa (BH) score, validated signature using 52 hypoxia-regulated genes. Microbe relative abundances modeled primary location high vs. low tertile BH applying gamma-distributed generalized linear regression “stats” R, adjusted p-value < 0.05 considered significant. Conclusions: In our study, oral found be more hypoxic other could potentially contribute their resistance. For each subsite, distinct microbial populations over-represented subsite-specific manner. Further studies focusing on an microbiome, patient outcomes are warranted.

Language: Английский

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Environmental insults and compensative responses: when microbiome meets cancer

Discover Oncology, Journal Year: 2023, Volume and Issue: 14(1)

Published: July 15, 2023

Abstract Tumor microenvironment has recently been ascribed a new hallmark—the polymorphic microbiome. Accumulating evidence regarding the tissue specific territories of tumor-microbiome have opened and interesting avenues. A pertinent question is functional consequence interface between host-microbiome cancer. Given microbial communities predominantly explored through an ecological perspective, it important that foundational aspects stress fight to ‘survive thrive’ are accounted for tumor-micro(b)environment as well. Building on existing classical ecology, here we attempt characterize stresses compensative responses microorganisms inside tumor microenvironment. What insults would microbes experience cancer jungle? How they respond these insults? interplay quest survival influence fate tumor? This work asks questions tries describe this underdiscussed its microbiota. It hoped larger scientific thought importance competition sensing vis-à-vis tumor-microenvironment be stimulated.

Language: Английский

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The impact of intestinal and mammary microbiomes on breast cancer development: A review on the microbiota and oestrobolome roles in tumour microenvironments.

The American Journal of Surgery, Journal Year: 2024, Volume and Issue: 237, P. 115795 - 115795

Published: June 5, 2024

Language: Английский

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Tumor microenvironment-related multigene prognostic prediction model for breast cancer

Aging, Journal Year: 2022, Volume and Issue: 14(2), P. 845 - 868

Published: Jan. 20, 2022

Breast cancer is an invasive disease with complex molecular mechanisms. Prognosis-related biomarkers are still urgently needed to predict outcomes of breast patients.

Language: Английский

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Metabolic Alteration of MCF-7 Cells upon Indirect Exposure to E. coli Secretome: A Model of Studying the Microbiota Effect on Human Breast Tissue

Metabolites, Journal Year: 2023, Volume and Issue: 13(8), P. 938 - 938

Published: Aug. 11, 2023

According to studies, the microbiome may contribute emergence and spread of breast cancer. E. coli is one Enterobacteriaceae family recently found be present as part tissue microbiota. In this study, we focused on effect secretome free cells MCF-7 metabolism. Liquid chromatography–mass spectrometry (LC-MS) metabolomics was used study its role in intra- extracellular metabolites. A comparison made between secretome-exposed unexposed controls. Our analysis revealed significant alterations 31 intracellular 55 metabolites following exposure. Several metabolic pathways, including lactate, aminoacyl-tRNA biosynthesis, purine metabolism, energy were dysregulated upon can alter cancer cells’ metabolism through which disrupts key pathways cells. These microbial from hold promise biomarkers drug resistance or innovative approaches for treatment, either standalone therapies combination with other medicines.

Language: Английский

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Microorganisms and Other Cancers

Published: Jan. 1, 2024

Language: Английский

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Pan-Cancer Insights: A Study of Microbial Metabolite Receptors in Malignancy Dynamics

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4178 - 4178

Published: Dec. 15, 2024

Background/Objectives: The role of the gut microbiome in cancer biology has become an increasingly prominent area research, particularly regarding microbial metabolites and their receptors (MMRs). These metabolites, through various gut–organ axes, have been proven to influence several pathogenetic mechanisms. This study conducted a comprehensive pan-cancer analysis MMR transcriptomic profiles across twenty-three types, exploring mechanisms which they can development progression. Methods: Utilizing both cell lines from CCLE (Cancer Cell Line Encyclopedia) human tumor samples TCGA (The Cancer Gene Atlas), we analyzed 107 MMRs interacting with such as short-chain fatty acids, bile indole derivatives, others while studying interactions key known genes. Results: Our results revealed that certain MMRs, GPR84 serotonin receptors, are consistently upregulated malignancies, others, like ADRA1A, frequently downregulated, suggesting diverse roles pathophysiology. Furthermore, identified significant correlations between expression hallmark genes pathways, including immune evasion, proliferation, metastasis. Conclusions: findings suggest may serve potential biomarkers for diagnosis, prognosis, therapy, highlighting therapeutic potential. underscores significance microbiota–cancer axis provides novel insights into microbiome-based strategies treatment.

Language: Английский

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USO DE PRECEDEX NA VENTILAÇÃO NÃO INVASIVA PEDIÁTRICA: REVISÃO SISTEMÁTICA

Published: May 19, 2022

Introdução: A ventilação não invasiva é utilizada em pacientes pediátricos unidade de terapia intensiva por ser eficaz para o tratamento insuficiência respiratória relacionada a doenças respiratórias. No entanto, há uma grande taxa falha decorrência da inquietação. Diante disso, dexmedetomidina, agonista α2-adrenérgico, como agente sedação primário ou no período peri-extubação apresentar melhores resultados na comparação com os demais sedativos. Os efeitos adversos mais frequentes descritos são hipotensão e bradicardia. Objetivo: Realizar revisão sistemática estudos observacionais durante mecânica fazendo uso bem seu mecanismo ação, benefícios, suas indicações. Métodos: Levantamento sistemático artigos publicados literatura, que consiste lista verificação contendo 27 itens um fluxograma quatro fases. Não foi limitado ano, fim analisar criticamente principais elementos relacionados à interação entre medicamento população pediátrica invasiva. critérios seleção dos incluíram dexmedetomidina (0 18 anos). Resultados: O emprego apresentou-se forma positiva após extubação causar depressão do sistema ventilatório também eficácia significativa nos apresentaram agitação sedativo teve hemodinâmicos bradicardia hipertensão, além sinais abstinência, quais foram relatados retirada droga. Sendo assim, esse receptor alfa-2 tem sido utilizado escolha ênfase devido ausência efeito depressor respiratório, adequada ação sedativa analgésica antiarrítmicos favoráveis. Conclusão: mostraram extubação, apesar poder hipertensão. Palavras-chave: invasiva, criança, intensiva.

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