Neopterin, the Cell-Mediated Immune Response Biomarker, in Inflammatory Periodontal Diseases: A Narrative Review of a More than Fifty Years Old Biomarker

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1294 - 1294

Published: April 27, 2023

Neopterin is a biomarker of the activation cellular immunity. The purpose this review to summarise neopterin metabolism, methods its detection, and role in inflammation, focusing on periodontal inflammatory diseases. This derivative guanosine non-enzymatic product 7,8-dihydroneopterin oxidation caused by free radicals which protect activated macrophages from oxidative stress. Various methods, usually based enzyme-linked immunosorbent essay, high-performance liquid chromatography, or radioimmunoassay were developed for isolation neopterin. A wide spectrum diseases conditions are known affect levels, including cardiovascular, bacterial, viral, degenerative diseases, as well malignant tumours. levels found increase subjects with periodontitis, especially when oral fluid gingival crevicular evaluated. These findings confirm immunity appear be most valuable biologic fluids evaluation periodontitis. For fluid, can determined concentration so-called total amount. Nonsurgical treatment was associated decrease but an also reported, suggesting possible resolution lesion.

Language: Английский

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GDF15, EGF, and Neopterin in Assessing Progression of Pediatric Chronic Kidney Disease Using Artificial Intelligence Tools—A Pilot Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2344 - 2344

Published: March 6, 2025

Cell-mediated immunity and chronic inflammation are hallmarks of kidney disease (CKD). Growth differentiation factor 15 (GDF15) is a marker an integrative signal in stress conditions. Epidermal growth (EGF) tubule-specific protein that modulates the regeneration injured renal tubules. Neopterin product activated monocytes macrophages serves as cell-mediated immunity. Our aim was to assess role above-mentioned parameters progression CKD children using artificial intelligence tools. The study group consisted 151 with stages 1-5. EGF, GDF15, neopterin serum concentrations were assessed by ELISA. patients' anthropometric data, biochemical parameters, values implemented into neural network (ANN). most precise model contained input classified patients either 1-3 or 4-5 groups excellent accuracy 96.77%. presented AI model, may serve useful predictor progression. It suggests essential inflammatory processes function decline course children.

Language: Английский

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Low serum neopterin early indicates durable benefits of atezolizumab and pembrolizumab therapy in advanced lung cancer

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 16, 2025

Language: Английский

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Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 17, 2022

Abstract Multisystem inflammatory syndrome in children (MIS-C) is a rare, life-threatening complication of severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. MIS-C develops with high fever, marked inflammation and shock-like picture several weeks after exposure to, or mild infection SARS-CoV-2. Deep immune profiling identified activated macrophages, neutrophils, B-plasmablasts CD8 + T cells as key determinants pathogenesis together multiple markers. The disease rapidly responds to intravenous immunoglobulin (IVIG) treatment clear changes features. Here we present the results comprehensive analysis complement system context activity describe characteristic during IVIG treatment. We show that activation markers classical, alternative terminal pathways are highly elevated, largely independent anti-SARS-CoV-2 humoral response, but strongly associated macrophage activation. Decrease closely rapid improvement

Language: Английский

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Neopterin and kynurenine in serum and urine as prognostic biomarkers in hospitalized patients with delta and omicron variant SARS-CoV-2 infection

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2023, Volume and Issue: 61(11), P. 2053 - 2064

Published: June 7, 2023

Currently, no biomarker or scoring system could clearly identify patients at risk of progression to a severe coronavirus disease (COVID)-19. Even in with known factors, the fulminant course cannot be predicted certainty. Analysis commonly determined clinical parameters (frailty score, age, body mass index) together routine biomarkers host response (C-reactive protein and viral nucleocapsid protein) combination new neopterin, kynurenine, tryptophan, aid predicting patient outcome.In 2021 2022, urine serum samples were prospectively collected on 1st 4th day after hospital admission 108 consecutive COVID-19 hospitalized University Hospital Hradec Králové, Czech Republic. Delta omicron virus variants studied. Neopterin, kynurenine tryptophan by liquid chromatography.A significant correlation was observed between urinary concentrations. Urinary kynurenine/tryptophan ratio significantly (p≤0.05) higher who subsequently needed oxygen therapy vs. without therapy. These also increased died during hospitalization compared survivors. Complex equations have been derived using investigated other laboratory predict subsequent death hospitalization.Present data demonstrate that represent promising management may help guide important therapeutic decisions.

Language: Английский

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Ferric Ions Modulated Carbon Dots as a Fluorescent Probe for the Detection of Neopterin: An Inflammatory Prognostic Marker for Risk Prediction and Severity of Covid‐19

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(22)

Published: June 6, 2023

Abstract Neopterin (NPT) is a Guanosine Tri Phosphate (GTP) metabolite produced by activated macrophages and considered pro‐inflammatory atherosclerotic agent. Beyond this NPT multi‐utility biomarker for assessing the status of various diseases including cardiovascular disease, depression, malignant tumors as well infections viral bacterial origin. Recent clinical investigations suggest use prognostic marker early prediction severity Covid‐19, which prime concern global public health. One main immunopathological characteristics Covid‐19 an excessive inflammatory response, infection linked with macrophage activation syndrome (MAS). Hence assessment neopterin serves effective diagnostic tool risk Covid‐19. We present fluorescence turn‐on sensor using ferric ion‐modulated sulfur nitrogen co‐doped carbon quantum dots. The linear detection was achieved limit 3.11 nM.

Language: Английский

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The usability of neopterin in determining disease course in COVID-19

Saudi Medical Journal, Journal Year: 2023, Volume and Issue: 44(8), P. 767 - 772

Published: Aug. 1, 2023

To investigate the usability of neopterin in demonstrating progression COVID-19. As a result uncontrolled activation COVID-19 monocytes and macrophages, IFN gamma increases resulting inflammatory response causes organ damage. released from T cells an increase levels. Therefore, measurement levels can be used to indicate immune system disease progression.The study was carried out prospectively two different centers. The patients were divided into groups (mild-moderate severe) clinical, laboratory, imaging findings at hospitalization compared.100 included our study, 41 these male. Forty-six identified as severe C-reactive protein, lymphocyte count, fibrinogen, D dimers, lactate dehydrogenase, procalcitonin, troponin significant indicating severity. (p<0.05). In ROC analysis, 0.642 for neopterin, 0.698 0.331 0.679 0.633 0.667 0.655 0.706 dehydrogenase detected values significant.In important indicator determining course

Language: Английский

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Evaluation of serum neopterin levels in severe COVID-19 patients: An observational study

Medicine, Journal Year: 2024, Volume and Issue: 103(30), P. e38996 - e38996

Published: July 26, 2024

In patients with coronavirus disease (COVID-19), a massive inflammatory response is significant cause of morbidity and mortality. Inflammatory markers are prognostic indicators severity the ultimate clinical outcome. Several studies have demonstrated correlation between serum levels neopterin, which can be an immune system marker, severity, poor outcomes in COVID-19 patients. Our study aimed to determine diagnostic significance neopterin conjunction routinely measured severe COVID-19. Serum C-reactive protein (CRP), albumin levels, complete blood count were determined 39 30 healthy individuals. Demographic characteristics, other laboratory data compared volunteers statistically analyzed. High observed volunteers. Furthermore, decreased, while CRP increased patients, significantly. Also, positive correlations shown negative levels. Systemic inflammation markers, CRP/albumin ratio, neutrophil/lymphocyte platelet/lymphocyte ratio significantly higher, lymphocyte/monocyte was also lower than However, not linked or ratio. On hand, they negatively findings highlight association high Neopterin correlated traditional biomarkers may indicate general activation

Language: Английский

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Neopterin production in relation to COVID-19 in the Haut-Ogooué Province, Gabon

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 24, 2023

Background At the beginning of COVID-19 pandemic, immunological aspects SARS-CoV-2 were not at forefront research in sub-Saharan Africa. In this context, study aimed to investigate association between plasma neopterin concentrations and infection, with a focus on changes over time age-related immune response. Methods We included cohort 325 individuals, consisting 124 201 healthy controls June August 2020. Whole blood associated symptoms comorbidities collected from all individuals enrollment longitudinally 28 days. Concentrations measured using commercial competitive ELISA (Neopterin ELISA, IBL International GmbH, Germany). Results found elevated concentration (mean ± SD: 50.0 15) compared 34.0 1.6), indicating active responses cases. Longitudinal analysis showed decline levels time, initial sampling (first day) it was 42.00 12.00 nmol/l, measure day 10 30.00 02.00 nmol/l 14 25.00 05.00 nmol/l. Moreover, significant positive correlation age. This increase may indicate more pronounced response older individuals. Conclusion provides evidence an indicates as marker capable diagnosing age related young one. Our suggests also that serve valuable biomarker for assessing monitoring disease progression during outbreak.

Language: Английский

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Immunopterin: A prospective therapy and preventative to fight COVID-19?

Pteridines, Journal Year: 2022, Volume and Issue: 33(1), P. 11 - 20

Published: Jan. 1, 2022

Abstract Background The authors explore the therapeutic and prophylactic efficacies of Immunopterin (calcium pterin-6-carboxylate chelate) against coronavirus colds as a therapy COVID-19. Methods To determine Immunopterin’s efficacy flus, 5-year observational study was conducted with 34 subjects who took when feeling symptoms cold or flu. mean sample recovery time compared to US population mean. A review Moheno (2014) 2-year evaluate colds. Early COVID-19 case studies, treated Immunopterin, were collected COVID19 disease. Results for in cold/flu 30 h 168 ( N = 34; p < 0.001). Subjects taking reported 0% incidences flus 31). successfully four confirmed subjects. fifth clinical nurse demonstrates prevention. Conclusions colds, along cross-reactivity between SARS-CoV-2 strongly suggest can act preventative COVID- 19 infection associated

Language: Английский

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