Efficacy of a dual task protocol on neurophysiological and clinical outcomes in migraine: a randomized control trial

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(8), P. 4015 - 4026

Published: May 29, 2024

Abstract The main aim of this study was to investigate the efficacy a dual task protocol in people with episodic migraine respect both active exercises only and cognitive treatments, concerning some neurophysiological clinical outcomes. A randomized control trial adopted without aura. Some outcomes were collected (t0): resting motor threshold (rMT), short intracortical inhibition (SICI) facilitation (ICF), pressure pain (PPT), trail making test (TMT), frontal assessment battery (FAB), headache-related disability (MIDAS) headache parameters. Then, participants into three groups: exercise (n = 10), 10) 10). After 3 months each treatment after 1-month follow-up same revaluated. significant time x group effect found for trapezius muscle (p 0.012, pη2 0.210), suggesting that PPT increased significantly groups. rMT < 0.001, 0.473), MIDAS 0.426), TMT 0.338) FAB 0.462). repeated measures ANOVA SICI at ms highlighted statistically 0.629), but not 0.565, 0.061), training 0.357, 0.108). seems have more evident on habituation sensitization than two monotherapies taken alone migraine.

Language: Английский

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Efficacy of dual-task augmented reality rehabilitation in non-hospitalized adults with self-reported long COVID fatigue and cognitive impairment: a pilot study

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(4), P. 1325 - 1333

Published: Jan. 9, 2024

Language: Английский

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A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1545 - 1545

Published: May 21, 2024

Myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS), and long COVID are complex, multisystemic long-term disabling conditions characterized by debilitating post-exertional malaise other core symptoms related to immune dysregulation resultant from post-viral infection, including mitochondrial dysfunction, neuroinflammation gut dysbiosis. The reported associations between altered microbiota composition cardinal of ME/CFS suggest that the use microbial preparations, such probiotics, restoring homeostasis brain–immune–gut axis, may help in management both conditions. Therefore, this review aims investigate implications alerted microbiome assess evidence supporting microbial-based synbiotics, postbiotics alone and/or combination with nutraceuticals fatigue, inflammation neuropsychiatric gastrointestinal among patients COVID.

Language: Английский

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Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 293 - 293

Published: March 20, 2024

Neurological involvement following coronavirus disease 19 (COVID-19) is thought to have a neuroinflammatory etiology. Co-ultraPEALut (an anti-inflammatory molecule) and luteolin anti-oxidant) shown promising results as neuroinflammation antagonists. The aim of this study was describe cognitive impairment in patients with post-COVID-19 treated co-ultraPEALut. Montreal Cognitive Assessment (MoCA), the Prospective–Retrospective Memory Questionnaire (PRMQ), Fatigue Severity Scale (FSS), subjective assessment were administered at baseline after 10 months. Patients co-ultraPEALut retrospectively compared controls. Twenty-six showed significant improvement PRMQ (T0: 51.94 ± 10.55, T1: 39.67 13.02, p < 0.00001) MoCA raw score 25.76 2.3, 27.2 2, 0.0260); MoCA-adjusted FSS questionnaires also an improvement, even though it not statistically significant; 80.77% reported improvement. In control subjects (n = 15), pronounced (PRMQ T0: 45.77 13.47, 42.33 16.86, 0.2051; 4.95 1.57, 4.06 1.47, 0.1352). corticosteroids different from those alone. Neuro-post-COVID-19 scored better than controls months: may support importance modulation for neuro-long-COVID-19.

Language: Английский

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Management of cognitive impairment associated with post-COVID-19 syndrome: recommendations for primary care

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 22, 2024

Introduction: Although post-COVID-19 syndrome (PCS) with cognitive impairment is increasingly encountered in primary care, evidence-based recommendations for its appropriate management are lacking. Methods: A systematic literature search evaluating the diagnosis and treatment of associated PCS was conducted. Practical PCS-associated care summarized, based on an evaluation pharmacological plausibility clinical applications. Results: Currently, pathology remains unclear no high-quality data to support targeted interventions. Existing approaches directed towards symptom relief where counseling chronicity disease regular reassessments at 4- 8-week intervals considered reasonable. Patients should be informed encouraged adopt a healthy lifestyle that centers around balanced nutrition physical activities. They may also benefit from intake vitamins, micronutrients, probiotics. The administration Ginkgo biloba extract could offer safe potentially beneficial option. Other non-pharmacological measures include physiotherapy, digitally supported training, and, if indicated, ergotherapy or speech therapy. In most patients, symptoms improve within 8 weeks. If serious, ambiguous, when new occur, specialized diagnostic such as comprehensive neurocognitive testing neuroimaging initiated. Very few patients would require inpatient rehabilitation. Conclusion: debilitating condition affect daily functioning reduce work productivity. Management multidisciplinary approach, centering physical, cognitive, therapies.

Language: Английский

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Neurophysiological and Clinical Outcomes in Episodic Migraine Without Aura: A Cross-Sectional Study

Journal of Clinical Neurophysiology, Journal Year: 2023, Volume and Issue: 41(4), P. 388 - 395

Published: Nov. 7, 2023

The aim of this study was to assess differences between people with episodic migraine and healthy controls in some neurophysiological clinical outcomes, which, turn, may highlight the sensory processing, especially cortical excitability, pain executive function.

Language: Английский

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Neuroimmunological Effect of Vitamin D on Neuropsychiatric Long COVID Syndrome: A Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3802 - 3802

Published: Aug. 30, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of disease 2019 (COVID-19). COVID-19 now recognized as a multiorgan with broad spectrum manifestations. A substantial proportion individuals who have recovered from are experiencing persistent, prolonged, and often incapacitating sequelae, collectively referred to long COVID. To date, definitive diagnostic criteria for COVID diagnosis remain elusive. An emerging public health threat neuropsychiatric COVID, encompassing range manifestations, such sleep disturbance, anxiety, depression, brain fog, fatigue. Although precise mechanisms underlying complications presently not fully elucidated, neural cytolytic effects, neuroinflammation, cerebral microvascular compromise, breakdown blood–brain barrier (BBB), thrombosis, hypoxia, neurotransmitter dysregulation, provoked neurodegeneration pathophysiologically linked long-term consequences, in addition systemic hyperinflammation maladaptation renin–angiotensin–aldosterone system. Vitamin D, fat-soluble secosteroid, potent immunomodulatory hormone potential beneficial effects on anti-inflammatory responses, neuroprotection, monoamine neurotransmission, BBB integrity, vasculometabolic functions, gut microbiota, telomere stability different phases SARS-CoV-2 infection, acting through both genomic nongenomic pathways. Here, we provide an up-to-date review pathophysiology plausible neurological contributions vitamin D mitigating

Language: Английский

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Height-dependent variation in corticospinal excitability modulation after active but not sham intermittent theta burst stimulation

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: 18, P. 498 - 511

Published: March 13, 2025

Poor reproducibility and high inter-individual variability in responses to intermittent theta burst stimulation (iTBS) of the human motor cortex (M1) are matters concern. Here we recruited 17 healthy young adults a randomized, sham-controlled, crossover study. Transcranial magnetic (TMS)-elicited evoked potentials (MEPs) were measured pre-iTBS (T0) post-iTBS at 4-7 (T1), 9-12 (T2), 17-20 (T3), 27-30 minutes (T4) from right first dorsal interosseous muscle. MEP grand average (MEPGA) was defined as mean normalized-to-baseline MEPs all timepoints post-iTBS. As secondary objectives, blood pressure, heart rate, capillary glucose pre-iTBS, 0 30 The TMSens_Q structured questionnaire filled out end each session. Two-way repeated ANOVA did not show significant TIME×INTERVENTION interaction effect on amplitude, latency, (p > 0.05). Sleepiness most reported sensation (82.3 %) both groups. Surprisingly, subjects' height negatively correlated with normalized amplitudes T3 (r = -0.65, p 0.005), T4 -0.66, 0.004), MEPGA -0.68, 0.003), trend correlation T1 -0.46, 0.062) T2 0.065) active but sham group. In view this, urge future studies delve deeper into influence neuroplasticity induction M1 representation peripheral muscles. end, highlight unique methodological considerations our study protocol recommendations for M1-iTBS studies.

Language: Английский

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Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 19, 2025

Abstract Background and purpose The glymphatic system, a waste clearance pathway, has been implicated in several neurological conditions associated with neuroinflammation. COVID-19 neurocognitive impairment, part of the post-acute sequelae SARS-CoV-2 infection (PASC), is strongly neuroinflammation disrupted blood-brain barrier (BBB). Several studies have synergistic interaction between system dysfunction BBB disruption. In this proof-of-concept study, we investigated role MRI metric diffusion along perivascular spaces DTI (DTI-ALPS) patients PASC correlated capillary permeability metric- K trans derived from Dynamic contrast enhanced (DCE) perfusion. Materials methods 14 subjects who had persisting symptoms anosmia, ageusia, fatigue, cognitive impairment (CI) ten healthy age sex matched controls were recruited. All underwent routine advanced MR brain imaging at two time points, (3 months +/- 2 weeks) after initial - referred as Time Point 1 (TP-1) 10 repeated scan 12 (+/- later (TP-2), while done only TP-1. mild impairment. final analysis included those study both points (n-10). DCE perfusion addition to anatomical imaging. Statistical Given small size sample nonnormality data descriptive analyses, nonparametric analyses used for group comparisons. A two-sample Wilcoxon rank sum test was show differences DTI-ALPS predefined regions interest. Spearman’s correlation coefficient (rho) assess index trans. Results There significant reduction left hemisphere (z = 2.04, p < 0.04). However, there no change over index. strong inverse central white matter (rho 0.66, 0.03). Conclusion Our indicates that disordered para vascular drainage, marker damage may contribute (NCI) among PASC. index, which does not require injection, potential serve non-invasive biomarker.

Language: Английский

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Lower Urinary Tract Symptoms in a prospective cohort of COVID-19 survivors

International braz j urol, Journal Year: 2024, Volume and Issue: 50(3), P. 287 - 295

Published: May 27, 2024

Purpose: To analyze the prevalence of lower urinary tract symptoms (LUTS) in patients who survived moderate and severe forms COVID-19 risk factors for LUTS six months after hospitalization. Materials Methods: In this prospective cohort study, were evaluated hospitalization due to COVID-19. assessed using International Prostate Symptom Score. General health was through Hospital Anxiety Depression Scale EQ5D-L5 scale, which evaluates mobility, ability perform daily activities, pain discomfort completed a self-perception evaluation. Results: Of 255 participants, 54.1% men median age 57.3 [44.3 – 66.6] years. Pre-existing comorbidities included diabetes (35.7%), hypertension (54.5%), obesity (30.2%) physical inactivity (65.5%). One hundred twenty-four (48.6%) had hospital stay >15 days, 181 (71.0%) admitted an ICU 124 needed mechanical ventilation. Median IPSS 6 [3-11] did not differ between genders. Moderate affected 108 (42.4%) (40.6% 44.4% women; p=0.610). Nocturia (58.4%) frequency (45.9%) most prevalent urgency only symptom that (29.0%) women (44.4%) differently (p=0.013). impacted quality life 60 (23.5%) with more severely (p=0.004). Diabetes, hypertension, worse general associated LUTS. Conclusions: are highly bothersome Assessment may help ensure appropriate diagnosis treatment these patients.

Language: Английский

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