FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets

Cancer Letters, Journal Year: 2020, Volume and Issue: 490, P. 174 - 185

Published: July 25, 2020

T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain immune homeostasis inhibit responses in various diseases, including cancer. Proportions of Tregs the peripheral blood some cancer patients increase by approximately two-fold, compared to those healthy individuals. contribute development progression suppressing effector cell functions, thereby compromising tumor killing promoting growth. Highly immunosuppressive express upregulated levels transcription factor, Forkhead box protein P3 (FoxP3). Elevated FoxP3+ within microenvironment (TME) showed a positive correlation with poor prognosis patients. Despite success immunotherapy, use checkpoint inhibitors, significant proportion show low response rates as result primary or acquired resistance against therapy. Some mechanisms which underlie therapy are associated Treg suppressive function. In this review, we describe contribution development/progression, Treg-mediated immunosuppression. We discuss prognostic significance different cancers their potential biomarkers. also therapeutic strategies target combination other types immunotherapies aiming overcome improve clinical outcomes Overall, understanding could help more effective targeted enhance

Language: Английский

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Immune Cell Interactions and Immune Checkpoints in the Tumor Microenvironment of Gastric Cancer

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1156 - 1156

Published: Jan. 29, 2025

Gastric cancer (GC) ranks as the fifth most prevalent malignant neoplasm globally, with an increased death rate despite recent advancements in research and therapeutic options. Different molecular subtypes of GC have distinct interactions immune system, impacting tumor microenvironment (TME), prognosis, reaction to immunotherapy. Tumor-infiltrating lymphocytes (TILs) TME are crucial for preventing growth metastasis, evidenced by showing that patients who a significant density TILs better survival rates. But cells evolved variety mechanisms evade surveillance, both sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) Programmed Death-Ligand 1 (PD-L1) playing pivotal role development immunosuppressive TME. They prevent T cell activation proliferation resulting decrease system’s capacity recognize eliminate cells. These checkpoint molecules function via different but complementary mechanisms, expression Siglec-15 being mutually exclusive PD-L1 and, therefore, providing approach. The review explores how affect patient outcomes GC, particular emphasis on their within potential targeting pathways

Language: Английский

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Brave new world—new and emerging treatments for gastric cancer

Chinese Clinical Oncology, Journal Year: 2023, Volume and Issue: 12(5), P. 54 - 54

Published: Sept. 11, 2023

Despite considerable international heterogeneity in the incidence and histological subtypes of gastric cancer (GC), addition to more recent epidemiological trends, chemotherapy has long represented main systemic therapeutic option its treatment. For roughly 20% GC with human epidermal growth factor receptor 2 (HER2) overexpression, there is a recently established role for HER2+ based therapy form trastuzumab. However, while immune checkpoint inhibitors (ICIs) have revolutionised treatment other malignancies including melanoma renal cell carcinoma over past decade, they only gained foothold years. This article reviews existing evidence ICIs as novel option. It also looks ongoing trials inhibition both perioperative advanced setting, combination targets HER2+. Other investigational therapies chimeric antigen T-cell (CAR-T) anti-T immunoreceptor immunoglobulin tyrosine-based inhibitory motif domain (anti-TIGIT) are considered, reviewing building alternative currently under investigation GC, fibroblast 2b (FGFR2b) claudin 18.2 amongst others. These evolving represent brave new world intervention potential transform outcomes patients internationally.

Language: Английский

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The Immune Microenvironment Impacts Survival in Western Patients with Gastric Adenocarcinoma

Journal of Gastrointestinal Surgery, Journal Year: 2019, Volume and Issue: 24(1), P. 28 - 38

Published: Oct. 17, 2019

Language: Английский

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Genetically engineered neural stem cells expressing cytosine deaminase and interferon-beta enhanced T cell-mediated antitumor immunity against gastric cancer in a humanized mouse model

Life Sciences, Journal Year: 2023, Volume and Issue: 328, P. 121866 - 121866

Published: June 16, 2023

Language: Английский

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Gastric cancer patients display a distinctive population of IFNg+IL10+ double positive CD8 T cells, which persists longer during prolonged activation

Experimental Cell Research, Journal Year: 2019, Volume and Issue: 382(2), P. 111487 - 111487

Published: June 28, 2019

Language: Английский

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