Navigating the Role and Approach of Gut Microbiota in Addressing Alzheimer's Disease Pathogenesis DOI Creative Commons

Imrana Jazuli,

Akeela Jazeel,

Lakshmi Selvaratnam

et al.

Progress In Microbes & Molecular Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 29, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta plaques and tau protein neurofibrillary tangles, leading to cognitive decline. The lack of effective treatments compounds the significant human financial burdens AD poses. Despite extensive research, exact mechanisms remain elusive. Recent studies have shown promise in using anti-Aβ antibodies reduce accumulation slow dementia progression. However, diversifying therapeutic strategies crucial for making meaningful progress. In recent years, research has increasingly focused on microbiota-gut-brain axis AD. Mounting evidence suggests that changes gut microbiota composition are linked progression, implicating various pathways. Dysregulation taxa can trigger systemic inflammation increasing permeability, ultimately neural damage neurodegeneration. Poor dietary habits aging exacerbate dysbiosis, worsening pathology. investigations this area still their early stages, with many aspects awaiting exploration understanding. A thorough comprehension complex interactions within microbiota-AD relationship essential refining approaches. Interventions targeting microbiota, such as adjustments, probiotics, faecal transplantation, offer potential therapeutics. This review highlights detrimental role dysbiosis AD, offering insights into enhancing avenues disease. Graphical abstract: bidirectional interaction between brain through neuroendocrine, immune, metabolic Created BioRender.com

Language: Английский

Gut Microbes: Therapeutic Target for Neuropsychiatric Disorders DOI
Keya Mallick, Gopal Khodve,

Ritika Ruwatia

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 27 - 38

Published: Feb. 21, 2025

Language: Английский

Citations

0
Klebsiella pneumoniae infection increases risk of Alzheimer's disease in the UK Biobank cohort DOI Open Access
Steven Lehrer, Peter H. Rheinstein

Psychogeriatrics, Journal Year: 2025, Volume and Issue: 25(2)

Published: Feb. 22, 2025

Abstract Background Infections, including bacterial pathogens, have been implicated in Alzheimer's disease (AD) risk. Klebsiella pneumoniae ( K. ) is a common hospital‐acquired pathogen associated with significant inflammation, which may contribute to neurodegeneration. This study investigates the relationship between infections and AD UK Biobank cohort. Methods Using data, we assessed diagnoses based on linked healthcare records identified using International Classification of Disease 10 th Edition codes B96.1 J15.0. A cohort 502 494 participants was analyzed for incidence relation demographic factors, educational years, apolipoprotein E (APOE) isoforms, history infection. Logistic regression used assess association infection Results significantly higher among (1.0%) compared those without (0.2%; P < 0.001, Fisher's exact test two‐tailed). analysis revealed that an increased risk (odds ratio = 3.32, 0.001), independent age, sex, education, APOE isoform. Additionally, ε4ε4 carriers age but decreased additional years education. Conclusion Our findings suggest be factor AD. underscores need further research into control its role mitigating neurodegenerative risk, particularly populations susceptible healthcare‐associated infections.

Language: Английский

Citations

0
Cross-talks between osteoporosis and gut microbiome DOI
Shiva Shankar Jha, Naveen Jeyaraman,

Madhan Jeyaraman

et al.

World Journal of Orthopedics, Journal Year: 2025, Volume and Issue: 16(3)

Published: March 12, 2025

Language: Английский

Citations

0
Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions DOI
Naveen Jeyaraman,

Madhan Jeyaraman,

Priya Dhanpal

et al.

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

The gut microbiome, a complex ecosystem of microorganisms, has significant role in modulating pain, particularly within orthopaedic conditions. Its impact on immune and neurological functions is underscored by the gut-brain axis, which influences inflammation, pain perception, systemic responses. This integrative review examines current research how dysbiosis associated with various pathways, notably nociceptive neuroinflammatory mechanisms linked to central sensitization. We highlight advancements meta-omics technologies, such as metagenomics metaproteomics, deepen our understanding microbiome-host interactions their implications pain. Recent studies emphasize that gut-derived short-chain fatty acids microbial metabolites play roles neuroinflammation nociception, contributing management. Probiotics, prebiotics, synbiotics, faecal microbiome transplants are explored potential therapeutic strategies alleviate through modulation, offering an adjunct or alternative opioids. However, variability individual microbiomes poses challenges standardizing these treatments, necessitating further rigorous clinical trials. A multidisciplinary approach combining microbiology, immunology, neurology, orthopaedics essential develop innovative, personalized management rooted health, transform care.

Language: Английский

Citations

0
Zeolite and Neurodegenerative Diseases DOI Creative Commons
Stefan Panaiotov, Lyubka Tancheva, Reni Kalfin

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2614 - 2614

Published: June 2, 2024

Neurodegenerative diseases (NDs), characterized by progressive degeneration and death of neurons, are strongly related to aging, the number people with NDs will continue rise. Alzheimer’s disease (AD) Parkinson’s (PD) most common NDs, current treatments offer no cure. A growing body research shows that AD especially PD intricately intestinal health gut microbiome both can spread retrogradely from brain. Zeolites a large family minerals built [SiO4]4− [AlO4]5− tetrahedrons joined shared oxygen atoms forming three-dimensional microporous structure holding water molecules ions. The widespread used zeolite is clinoptilolite, additionally, mechanically activated clinoptilolites further improved beneficial effects. review describes discusses numerous positive effects clinoptilolite its forms on microbiome, as well their detoxifying, antioxidative, immunostimulatory, anti-inflammatory effects, relevant treatment PD. direct pathology in vitro vivo also reviewed, use zeolites biosensors delivery systems

Language: Английский

Citations

3
Distinct functional diversity of branched oligosaccharides as chaperones and inhibitory-binding partners of amyloid beta-protein and its aggregates DOI
He Li,

Changxin Zheng,

Yanru Zheng

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 261, P. 110141 - 110141

Published: Sept. 7, 2024

Language: Английский

Citations

1
Gut bacteria: an etiological agent in human pathological conditions DOI Creative Commons
Md Minarul Islam,

Nasir Uddin Mahbub,

Seong‐Tshool Hong

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 8, 2024

Through complex interactions with the host’s immune and physiological systems, gut bacteria play a critical role as etiological agents in variety of human diseases, having an impact that extends beyond their mere presence affects onset, progression, severity disease. Gaining comprehensive understanding these microbial is crucial to improving our disease pathogenesis creating tailored treatment methods. Correcting imbalances may open new avenues for prevention approaches, according preliminary data. The microbiota exerts integral part numerous health conditions, including metabolic, neurological, renal, cardiovascular, gastrointestinal problems well COVID-19, recent studies. significance microbiome highlighted by this role, which comparable hereditary variables. This review investigates contributions its host, development prospective therapeutic approaches. To fully harness benefits dynamics health, future research should address existing methodological challenges deepen knowledge interactions.

Language: Английский

Citations

1
Navigating the Role and Approach of Gut Microbiota in Addressing Alzheimer's Disease Pathogenesis DOI Creative Commons

Imrana Jazuli,

Akeela Jazeel,

Lakshmi Selvaratnam

et al.

Progress In Microbes & Molecular Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 29, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta plaques and tau protein neurofibrillary tangles, leading to cognitive decline. The lack of effective treatments compounds the significant human financial burdens AD poses. Despite extensive research, exact mechanisms remain elusive. Recent studies have shown promise in using anti-Aβ antibodies reduce accumulation slow dementia progression. However, diversifying therapeutic strategies crucial for making meaningful progress. In recent years, research has increasingly focused on microbiota-gut-brain axis AD. Mounting evidence suggests that changes gut microbiota composition are linked progression, implicating various pathways. Dysregulation taxa can trigger systemic inflammation increasing permeability, ultimately neural damage neurodegeneration. Poor dietary habits aging exacerbate dysbiosis, worsening pathology. investigations this area still their early stages, with many aspects awaiting exploration understanding. A thorough comprehension complex interactions within microbiota-AD relationship essential refining approaches. Interventions targeting microbiota, such as adjustments, probiotics, faecal transplantation, offer potential therapeutics. This review highlights detrimental role dysbiosis AD, offering insights into enhancing avenues disease. Graphical abstract: bidirectional interaction between brain through neuroendocrine, immune, metabolic Created BioRender.com

Language: Английский

Citations

1