Multi‐omics approach to socioeconomic disparity in metabolic syndrome reveals roles of diet and microbiome DOI
Faraz Bishehsari,

Michael Drees,

Darbaz Adnan

et al.

PROTEOMICS, Journal Year: 2023, Volume and Issue: 23(19)

Published: July 31, 2023

The epidemy of metabolic syndrome (MetS) is typically preceded by adoption a "risky" lifestyle (e.g., dietary habit) among populations. Evidence shows that those with low socioeconomic status (SES) are at an increased risk for MetS. To investigate this, we recruited 123 obese subjects (body mass index [BMI] ≥ 30) from Chicago. Multi-omic data were collected to interrogate fecal microbiota, systemic markers inflammation and immune activation, plasma metabolites, glycans. Intestinal permeability was measured using the sugar testing. Our results suggest heterogenous dysregulation populations who Systemic inflammation, linked poor diet, intestinal microbiome dysbiosis, gut barrier dysfunction may explain development MetS in these individuals. analysis revealed 37 key features associated numbers features. These used construct composite metabolic-inflammatory (MI) score able predict progression at-risk MI correlated several diet quality as well lower levels microbial diversity abnormalities species bacteria. This study reveals novel targets reduce burden suggests access healthy food options practical intervention.

Language: Английский

Childhood Obesity and Cardiovascular Disease Risk DOI Open Access
Stephanie T. Chung, Andrea Krenek, Sheela N. Magge

et al.

Current Atherosclerosis Reports, Journal Year: 2023, Volume and Issue: 25(7), P. 405 - 415

Published: May 31, 2023

Language: Английский

Citations

68
The Effect of Short-Term Consumption of Lactic Acid Bacteria on the Gut Microbiota in Obese People DOI Open Access
Inna Burakova, Yuliya Smirnova, Mariya Gryaznova

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(16), P. 3384 - 3384

Published: Aug. 18, 2022

Obesity is a problem of modern health care that causes the occurrence many concomitant diseases: arterial hypertension, diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. New strategies for treatment prevention obesity are being developed based on using probiotics modulation gut microbiota. Our study aimed to evaluate bacterial composition obese patients before after two weeks lactic acid bacteria (

Language: Английский

Citations

57
HMOs Exert Marked Bifidogenic Effects on Children’s Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition DOI Open Access
Danica Bajic,

Frank Wiens,

Eva Wintergerst

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1701 - 1701

Published: March 30, 2023

Prebiotics are substrates that selectively utilized by host microorganisms, thus conferring a health benefit. There is growing awareness interpersonal and age-dependent differences in gut microbiota composition impact prebiotic effects. Due to the interest using human milk oligosaccharides (HMOs) beyond infancy, this study evaluated how HMOs [2'Fucosyllactose (2'FL), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL), 6'Sialyllactose (6'SL)] blends thereof affect of 6-year-old children (

Language: Английский

Citations

30
Christensenella minuta, a new candidate next-generation probiotic: current evidence and future trajectories DOI Creative Commons
Olga Ignatyeva,

Darya Tolyneva,

A. A. Kovalyov

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

As the field of probiotic research continues to expand, new beneficial strains are being discovered. The

Language: Английский

Citations

12
Gut Microbiota and Neurotransmitter Regulation: Functional Effects of Four Traditional Chinese Fermented Soybean (Sojae Semen Praeparatum) DOI Creative Commons
Lin Zhang,

Su Huo,

Siqi Wang

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 671 - 671

Published: Feb. 16, 2025

This study aims to evaluate the potential disease prevention and treatment functions of four types traditional Chinese fermented Sojae Semen Praeparatum (SSP) by analyzing their nutritional active components effects on gut microbiota. Raw soybeans SSPs were administered as dietary supplements normal SD rats for 6 weeks. Fecal samples collected at weeks 0, 2, assess changes in Our results revealed that different fermentation methods resulted variations soybean isoflavone content. Fermented promoted growth beneficial microorganisms associated with short-chain fatty acid production microbiota, such Christensenellaceae_R_7_group, compared unfermented soybeans. Supplementation processes increased diversity rat except group qingwenjiedu decoction (QW). The dominant microbiota Artemisia Annuae Herba Mori Folium (QS) exhibited anti-inflammatory effects, while Ephedrae Perillae (MZ) showed antidepressant effects. In neurotransmitter analysis, MZ reduced gamma-aminobutyric (GABA) levels, without medicine (DD) decreased dopamine both QS QW norepinephrine levels. Correlation analysis highlighted connections between neurotransmitters, chemical indicate may contribute uniquely health maintaining intestinal balance improving neurological disorders predicting a association neurotransmitters correlation analysis.

Language: Английский

Citations

1
Contribution of the microbiome for better phenotyping of people living with obesity DOI Creative Commons
Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(5), P. 839 - 870

Published: April 29, 2023

Obesity has reached epidemic proportion worldwide and in all ages. Available evidence points to a multifactorial pathogenesis involving gene predisposition environmental factors. Gut microbiota plays critical role as major interface between external factors, i.e., diet, lifestyle, toxic chemicals, internal mechanisms regulating energy metabolic homeostasis, fat production storage. A shift composition is linked with overweight obesity, pathogenic bacterial products metabolites (mainly endocannabinoid-related mediators, short-chain fatty acids, bile catabolites of tryptophan, lipopolysaccharides) subsequent alterations gut barrier, altered insulin resistance chronic, low-grade inflammation. Although animal studies point the links an "obesogenic" development different obesity phenotypes, translational value these results humans still limited by heterogeneity among studies, high variation over time lack robust longitudinal adequately considering inter-individual confounders. Nevertheless, available underscores existence several genera predisposing or, conversely, lean metabolically health phenotype (e.g., Akkermansia muciniphila, species from Faecalibacterium, Alistipes, Roseburia). Further using metagenomics, transcriptomics, proteomics, metabolomics exact characterization confounders are needed this field. Results must confirm that distinct specific microbial-derived represent effective precision interventions against long-term.

Language: Английский

Citations

18
Christensenella strain resources, genomic/metabolomic profiling, and association with host at species level DOI Creative Commons

Xin‐Wei Sun,

Haojie Huang, Xiaomeng Wang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 9, 2024

The gut commensal bacteria

Language: Английский

Citations

6
Alterations in the gut microbiota community are associated with childhood obesity and precocious puberty DOI Creative Commons
Li Wang,

Qin Yi,

Hao Xu

et al.

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 24, 2024

To explore the distribution and differences in intestinal microbiota girls with obesity-related precocious puberty relationship between puberty. 16 S rRNA gene amplicons from fecal samples obesity-complicated healthy children were sequenced to define microbial taxa. The α- β-diversity indices of microbiome significantly differed among three groups. At phylum level, proportions Firmicutes, Actinobacteriota, Bacteroidota, Bacteria, Campylobacterota, Acidobacteriota different. genus there Bifidobacterium, Bacteroides, Anaerostipes, Fusicatenibacter, Klebsiella, Lachnospiraceae, ErysipelotrichaceaeUCG-003, Prevotella9, Ruminococcus gnavus group, Lachnoclostridium. Additionally, Candidatus Microthrix, Eubacterium hallii Erysipelotrichaceae UCG-003 identified as bacterial biomarkers by LEfSe. Furthermore, Sellimonas, Intestinibacter, Oscillibacter differential random forest. A receiver operating characteristic (ROC) curve was used evaluate high predictive value for Spearman correlation analysis confirmed that Anaerostipes levels negatively correlated body weight, mass index (BMI), bone age, luteinizing hormone, follicle-stimulating estradiol. There a significant obesity-associated gut microbiota, especially functional characteristics its interactions, which can provide theoretical basis clinical intervention obesity through microbiome.

Language: Английский

Citations

5
Personalized identification of Autism-related bacteria in the gut microbiome using eXplainable Artificial Intelligence DOI Creative Commons
Pierfrancesco Novielli, Donato Romano, Michele Magarelli

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110709 - 110709

Published: Aug. 13, 2024

Highlights•ML discriminates ASD and TD subjects using microbiome data•XAI identifies personalized biomarkers linked to ASD•Clustering based on SHAP embeddings reveals subgroups with different probabilitiesSummaryAutism spectrum disorder (ASD) affects social interaction communication. Emerging evidence links gut alterations, suggesting that microbial composition may play a role in the disorder. This study employs explainable artificial intelligence (XAI) examine contributions of individual species ASD. By local explanation unsupervised clustering, research distinct subgroups, underscoring disorder's heterogeneity. Specific associated are revealed, best classifiers achieved an AU-ROC 0.965 ± 0.005 AU-PRC 0.967 0.008. The findings support notion varies significantly among individuals work's broader significance lies its potential inform interventions, enhancing precision management classification. These insights highlight importance individualized profiles for developing tailored therapeutic strategies ASD.Graphical abstract

Language: Английский

Citations

4
Water-Soluble Cellulose Acetate Changes the Intestinal Microbiota in Mice with Non-Alcoholic Steatohepatitis DOI Open Access
Ayaka Iida,

Ena Takahashi,

Sachi Kuranuki

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 500 - 500

Published: Jan. 29, 2025

Objectives: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic disorder of the and affects many people worldwide. Intestinal bacteria are thought to be involved in pathological progression NAFLD; therefore, improving intestinal microbiota may important controlling NAFLD. In this study, we assessed effects water-soluble cellulose acetate (WSCA) on non-alcoholic steatohepatitis (NASH) mouse model. Methods: NASH model (STAM mice) was created by streptozotocin injection feeding mice high-fat diet. The serum biochemical parameters were analyzed. bacterial populations analyzed using paired-end sequencing 16S rRNA, 18S internal transcribed spacer gene. Results: Our findings indicated that WSCA administration tends improve alanine aminotransferase glucose levels STAM decreased alpha diversity altered beta their microbiota. Additionally, intake resulted an increase abundance Coriobacteriaceae_UCG-002 decrease Enterobacter. Conclusions: can alter specific microbial compositions blood functions pathogenesis

Language: Английский

Citations

0