Internal and Emergency Medicine, Journal Year: 2023, Volume and Issue: 19(1), P. 5 - 7
Published: Oct. 17, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5640 - 5640
Published: May 22, 2024
The epidemiological burden of liver steatosis associated with metabolic diseases is continuously growing worldwide and in all age classes. This condition generates possible progression damage (i.e., inflammation, fibrosis, cirrhosis, hepatocellular carcinoma) but also independently increases the risk cardio-metabolic cancer. In recent years, terminological evolution from “nonalcoholic fatty disease” (NAFLD) to “metabolic dysfunction-associated (MAFLD) and, finally, steatotic (MASLD) has been paralleled by increased knowledge mechanisms linking local hepatic) systemic pathogenic pathways. As a consequence, need for an appropriate classification individual phenotypes oriented investigation innovative therapeutic tools. Besides well-known role lifestyle change, number pharmacological approaches have explored, ranging antidiabetic drugs agonists acting on gut–liver axis at level (mainly farnesoid X receptor (FXR) agonists, PPAR thyroid hormone agonists), anti-fibrotic anti-inflammatory agents. intrinsically complex pathophysiological history MASLD makes selection single effective treatment major challenge, so far. this evolving scenario, cooperation between different stakeholders (including subjects risk, health professionals, pharmaceutical industries) could significantly improve management disease implementation primary secondary prevention measures. high healthcare search new, effective, safe pressing need, together accurate characterization phenotypes. Recent promising advances indicate that we may soon enter era precise personalized therapy MASLD/MASH.
Language: Английский
Citations
27
Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 140, P. 104171 - 104171
Published: Sept. 12, 2023
Language: Английский
Citations
42
Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 63 - 63
Published: Dec. 25, 2023
Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) associated with faster more relevant impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk falls, frailty, overall quality life, mortality. PubMed/Medline, Scopus, Web Science, Google Scholar were searched for research articles, scientific reports, observational studies, trials, narrative systematic reviews, meta-analyses review evidence pathophysiology di-abetes-induced sarcopenia, its relevance in terms glucose control diabetes-related outcomes, diagnostic therapeutic challenges. The comprehensively addresses key elements definition criteria pathophysiological correlation be-tween T2D, related a critical role antihyperglycemic treatment health, perspectives specific targeting myokine signaling pathways involved regulation metabolism trophism. Prompt diagnosis adequate management, including lifestyle inter-vention, diet programs, micronutrient supplementation, physical exercise, pharmaco-logical treatment, are needed prevent or delay T2D.
Language: Английский
Citations
36
European Journal of Internal Medicine, Journal Year: 2023, Volume and Issue: 119, P. 13 - 30
Published: Oct. 4, 2023
Language: Английский
Citations
32
Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(5), P. 767 - 773
Published: Aug. 4, 2023
In this thematic issue on phenotyping the obesities, prominent international experts offer an insightful and comprehensive collection of articles covering current knowledge in field. order to actually capture all polyhedral determinants diverse types obesity, granularity phenotypic information acquired must be expanded context a personalized approach. Whilst use precision medicine has been successfully implemented areas like cancer other diseases, health care providers are more reluctant embrace detailed guide diagnosis, treatment prevention obesity. Given its multiple complex layers, necessarily needs go beyond multi-omics approach incorporate spheres that conform reality people living with Potential barriers, difficulties, roadblocks opportunities together their interaction syndemic analyzed. Plausible lacunae also highlighted addition pointing need redefining new conceptual frameworks. Therefore, extraordinary state-ofthe-art reviews provides useful both experienced clinicians trainees as well academics steer clinical practice research management obesity irrespective setting or career stage.
Language: Английский
Citations
21
Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2333 - 2333
Published: Nov. 15, 2024
The human gut is a complex ecosystem that supports billions of living species, including bacteria, viruses, archaea, phages, fungi, and unicellular eukaryotes. Bacteria give genes enzymes for microbial host-produced compounds, establishing symbiotic link between the external environment host at both systemic levels. microbiome, which primarily made up commensal critical maintaining healthy host's immune system, aiding digestion, synthesizing essential nutrients, protecting against pathogenic as well influencing endocrine, neural, humoral, immunological functions metabolic pathways. Qualitative, quantitative, and/or topographic shifts can alter resulting in dysbiosis dysfunction, contribute to variety noncommunicable illnesses, hypertension, cardiovascular disease, obesity, diabetes, inflammatory bowel cancer, irritable syndrome. While most evidence date observational does not establish direct causation, ongoing clinical trials advanced genomic techniques are steadily enhancing our understanding these intricate interactions. This review will explore key aspects relationship microbiota, eubiosis, health highlighting emerging strategies microbiome engineering potential therapeutic approaches various conditions.
Language: Английский
Citations
8
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Dec. 11, 2024
High sugar, high-fat diets and unhealthy lifestyles have led to an epidemic of obesity obesity-related metabolic diseases, seriously placing a huge burden on socio-economic development. A deeper understanding elucidation the specific molecular biological mechanisms underlying onset development has become key treatment diseases. Recent studies shown that changes bile acid composition are closely linked Bile acids can not only emulsify lipids in intestine promote lipid absorption, but also act as signaling molecules play indispensable role regulating homeostasis, energy expenditure, glucose metabolism, immunity. Disorders metabolism therefore important risk factors for The farnesol X receptor, member nuclear receptor family, is abundantly expressed liver intestinal tissues. endogenous ligands erroneous FXR triggered by dysregulation contributes including obesity, non-alcoholic fatty disease diabetes. Activation reduce lipogenesis inhibit gluconeogenesis alleviate It been found regulate hepatic organ-wide manner. crosstalk between provides new idea This review focuses relationship diseases current research progress provide theoretical basis further clinical applications.
Language: Английский
Citations
8
Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156653 - 156653
Published: March 16, 2025
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1601 - 1601
Published: July 18, 2024
Obesity, along with metabolic disorders such as dyslipidemia and insulin resistance, increases the risk of cardiovascular disease, diabetes, various cancers, other non-communicable diseases, thereby contributing to higher mortality rates. The intestinal microbiome plays a crucial role in maintaining homeostasis influencing human metabolism. This study enrolled 82 young obese individuals, who were stratified into groups or without disturbances. No significant differences alpha beta diversity microbiota observed among groups. Insulin resistance was characterized by an increase number Adlercreutzia Dialister well decrease Collinsella, Coprococcus Clostridiales. dyslipidemia+insulin had no gut microbiota. Dietary patterns also influenced microbial composition, high protein intake increasing Leuconostoc Akkermansia, fiber boosting Lactobacillus Streptococcus. genus Erwinia associated visceral fat serum glucose high-density lipoprotein cholesterol. Our findings highlight association between composition disturbances they suggest that dietary modifications may promote healthy reduce developing disorders.
Language: Английский
Citations
4
Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(8), P. 100976 - 100976
Published: April 11, 2024
Intestinal dysbiosis and disrupted bile acid (BA) homeostasis are associated with obesity, but the precise mechanisms remain insufficiently explored. Hepatic protein phosphatase 1 regulatory subunit 3G (PPP1R3G) plays a pivotal role in regulating glycolipid metabolism; nevertheless, its obesity-combatting potency remains unclear. In this study, substantial reduction was observed serum PPP1R3G levels high-body mass index high-fat diet (HFD)-exposed mice, establishing positive correlation between non-12α-hydroxylated (non-12-OH) BA content. Additionally, hepatocyte-specific overexpression of Ppp1r3g (PPP1R3G HOE) mitigated HFD-induced obesity as evidenced by reduced weight fat mass, an improved lipid profile; hepatic steatosis alleviation confirmed normalized liver enzymes histology. HOE considerably impacted systemic homeostasis, which notably increased non-12-OH BAs ratio, particularly lithocholate (LCA). 16S ribosomal DNA (16S rDNA) sequencing assay indicated that reversed gut reducing Firmicutes/Bacteroidetes ratio Lactobacillus population, elevating relative abundance Blautia, exhibited LCA levels. A fecal microbiome transplantation test anti-obesity effect microbiota-dependent. Mechanistically, markedly suppressed cholesterol 7α-hydroxylase sterol-12α-hydroxylase, concurrently upregulated oxysterol 7-α hydroxylase Takeda G protein-coupled receptor 5 expression under HFD conditions. Furthermore, administration significantly phenotype elevated These findings emphasize significance ameliorating diet-induced adiposity through microbiota-BA axis, may serve potential therapeutic targets for obesity-related disorders.
Language: Английский
Citations
3