Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: Aug. 21, 2019
The
tumor
milieu
consists
of
numerous
cell
types
each
existing
in
a
different
environment.
However,
characterization
metabolic
heterogeneity
at
single-cell
resolution
is
not
established.
Here,
we
develop
computational
pipeline
to
study
programs
single
cells.
In
two
representative
human
cancers,
melanoma
and
head
neck,
apply
this
algorithm
define
the
intratumor
landscape.
We
report
an
overall
discordance
between
analyses
cells
those
bulk
tumors
with
higher
activity
malignant
than
previously
appreciated.
Variation
mitochondrial
found
be
major
contributor
heterogeneity.
Surprisingly,
expression
both
glycolytic
strongly
correlates
hypoxia
all
types.
Immune
stromal
could
also
distinguished
by
their
features.
Taken
together
analysis
establishes
framework
for
characterizing
metabolism
using
data
defines
principles
microenvironment.
Protein & Cell,
Journal Year:
2020,
Volume and Issue:
12(8), P. 599 - 620
Published: Oct. 1, 2020
Abstract
The
cystine/glutamate
antiporter
SLC7A11
(also
commonly
known
as
xCT)
functions
to
import
cystine
for
glutathione
biosynthesis
and
antioxidant
defense
is
overexpressed
in
multiple
human
cancers.
Recent
studies
revealed
that
overexpression
promotes
tumor
growth
partly
through
suppressing
ferroptosis,
a
form
of
regulated
cell
death
induced
by
excessive
lipid
peroxidation.
However,
cancer
cells
with
high
expression
(SLC7A11
)
also
have
endure
the
significant
cost
associated
SLC7A11-mediated
metabolic
reprogramming,
leading
glucose-
glutamine-dependency
cells,
which
presents
potential
vulnerabilities
therapeutic
targeting
cancer.
In
this
review,
we
summarize
diverse
regulatory
mechanisms
cancer,
discuss
ferroptosis-dependent
-independent
promoting
development,
explore
mechanistic
basis
SLC7A11-induced
nutrient
dependency
conceptualize
strategies
target
treatment.
This
review
will
provide
foundation
further
understanding
dependency,
biology
developing
novel
effective
therapies.
Oncogenesis,
Journal Year:
2016,
Volume and Issue:
5(1), P. e189 - e189
Published: Jan. 25, 2016
Abstract
Many
human
diseases,
including
metabolic,
immune
and
central
nervous
system
disorders,
as
well
cancer,
are
the
consequence
of
an
alteration
in
lipid
metabolic
enzymes
their
pathways.
This
illustrates
fundamental
role
played
by
lipids
maintaining
membrane
homeostasis
normal
function
healthy
cells.
We
reviewed
major
dysfunctions
occurring
during
tumor
development,
determined
using
systems
biology
approaches.
In
it,
we
provide
detailed
insight
into
essential
roles
exerted
specific
mediating
intracellular
oncogenic
signaling,
endoplasmic
reticulum
stress
bidirectional
crosstalk
between
cells
microenvironment
cancer
Finally,
summarize
advances
ongoing
research
aimed
at
exploiting
dependency
on
to
abolish
progression.
