Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids,
Journal Year:
2016,
Volume and Issue:
1861(4), P. 269 - 284
Published: Jan. 15, 2016
Autophagy
is
a
catabolic
process
with
an
essential
function
in
the
maintenance
of
cellular
and
tissue
homeostasis.
It
primarily
recognised
for
its
role
degradation
dysfunctional
proteins
unwanted
organelles,
however
recent
years
range
autophagy
substrates
has
also
been
extended
to
lipids.
Degradation
lipids
via
termed
lipophagy.
The
ability
contribute
lipo-homeostasis
becomes
particularly
relevant
context
genetic
lysosomal
storage
disorders
where
perturbations
autophagic
flux
have
suggested
disease
aetiology.
Here
we
review
discoveries
molecular
mechanisms
mediating
lipid
turnover
by
pathways.
We
further
focus
on
relevance
autophagy,
specifically
lipophagy,
mechanisms.
Moreover,
discussed
as
potential
therapeutic
target
several
key
disorders.
Journal of Clinical Investigation,
Journal Year:
2015,
Volume and Issue:
125(1), P. 25 - 32
Published: Jan. 1, 2015
mTOR,
a
serine/threonine
kinase,
is
master
regulator
of
cellular
metabolism.
mTOR
regulates
cell
growth
and
proliferation
in
response
to
wide
range
cues,
its
signaling
pathway
deregulated
many
human
diseases.
also
plays
crucial
role
regulating
autophagy.
This
Review
provides
an
overview
the
pathway,
mechanisms
autophagy
regulation,
clinical
implications
inhibitors
disease
treatment.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: May 31, 2021
Abstract
Due
to
the
advantages
in
efficacy
and
safety
compared
with
traditional
chemotherapy
drugs,
targeted
therapeutic
drugs
have
become
mainstream
cancer
treatments.
Since
first
tyrosine
kinase
inhibitor
imatinib
was
approved
enter
market
by
US
Food
Drug
Administration
(FDA)
2001,
an
increasing
number
of
small-molecule
been
developed
for
treatment
malignancies.
By
December
2020,
89
antitumor
FDA
National
Medical
Products
(NMPA)
China.
Despite
great
progress,
anti-cancer
still
face
many
challenges,
such
as
a
low
response
rate
drug
resistance.
To
better
promote
development
we
conducted
comprehensive
review
according
target
classification.
We
present
all
well
important
candidates
clinical
trials
each
target,
discuss
current
provide
insights
perspectives
research
drugs.
EBioMedicine,
Journal Year:
2017,
Volume and Issue:
21, P. 21 - 28
Published: April 11, 2017
Cellular
senescence
entails
essentially
irreversible
replicative
arrest,
apoptosis
resistance,
and
frequently
acquisition
of
a
pro-inflammatory,
tissue-destructive
senescence-associated
secretory
phenotype
(SASP).
Senescent
cells
accumulate
in
various
tissues
with
aging
at
sites
pathogenesis
many
chronic
diseases
conditions.
The
SASP
can
contribute
to
senescence-related
inflammation,
metabolic
dysregulation,
stem
cell
dysfunction,
phenotypes,
diseases,
geriatric
syndromes,
loss
resilience.
Delaying
senescent
accumulation
or
reducing
burden
is
associated
delay,
prevention,
alleviation
multiple
We
used
hypothesis-driven
approach
discover
pro-survival
Cell
Anti-apoptotic
Pathways
(SCAPs)
and,
based
on
these
SCAPs,
the
first
senolytic
agents,
drugs
that
cause
become
susceptible
their
own
pro-apoptotic
microenvironment.
Several
which
appear
alleviate
phenotypes
pre-clinical
models,
are
beginning
process
being
translated
into
clinical
interventions
could
be
transformative.
Endocrine Reviews,
Journal Year:
2018,
Volume and Issue:
39(4), P. 489 - 517
Published: April 24, 2018
The
ability
to
efficiently
adapt
metabolism
by
substrate
sensing,
trafficking,
storage,
and
utilization,
dependent
on
availability
requirement,
is
known
as
metabolic
flexibility.
In
this
review,
we
discuss
the
breadth
depth
of
flexibility
its
impact
health
disease.
Metabolic
essential
maintain
energy
homeostasis
in
times
either
caloric
excess
or
restriction,
low
high
demand,
such
during
exercise.
liver,
adipose
tissue,
muscle
govern
systemic
manage
nutrient
uptake,
transport,
expenditure
communication
via
endocrine
cues.
At
a
molecular
level,
relies
configuration
pathways,
which
are
regulated
key
enzymes
transcription
factors,
many
interact
closely
with
mitochondria.
Disrupted
flexibility,
inflexibility,
however,
associated
pathological
conditions
including
syndrome,
type
2
diabetes
mellitus,
cancer.
Multiple
factors
dietary
composition
feeding
frequency,
exercise
training,
use
pharmacological
compounds,
influence
will
be
discussed
here.
Last,
outline
important
advances
research
medical
horizons
translational
aspects.
