Signal Transduction and Targeted Therapy,
Journal Year:
2018,
Volume and Issue:
3(1)
Published: June 25, 2018
Cell
death
is
an
essential
biological
process
for
physiological
growth
and
development.
Three
classical
forms
of
cell
death-apoptosis,
autophagy,
necrosis-display
distinct
morphological
features
by
activating
specific
signaling
pathways.
With
recent
research
advances,
we
have
started
to
appreciate
that
these
processes
can
cross-talk
through
interconnecting,
even
overlapping,
pathways,
the
final
fate
result
interplay
different
programs.
This
review
provides
insight
into
independence
associations
among
three
types
explores
significance
under
conditions
human
diseases,
particularly
neurodegenerative
diseases
cancer.
International Journal of Molecular Sciences,
Journal Year:
2018,
Volume and Issue:
19(11), P. 3466 - 3466
Published: Nov. 5, 2018
Autophagy
is
an
intracellular
degradative
process
that
occurs
under
several
stressful
conditions,
including
organelle
damage,
the
presence
of
abnormal
proteins,
and
nutrient
deprivation.
The
mechanism
autophagy
initiates
formation
autophagosomes
capture
degraded
components
then
fuse
with
lysosomes
to
recycle
these
components.
modulation
plays
dual
roles
in
tumor
suppression
promotion
many
cancers.
In
addition,
regulates
properties
cancer
stem-cells
by
contributing
maintenance
stemness,
induction
recurrence,
development
resistance
anticancer
reagents.
Although
some
modulators,
such
as
rapamycin
chloroquine,
are
used
regulate
therapy,
since
this
also
both
promotion,
precise
requires
further
study.
review,
we
will
summarize
conditions
its
stem-cells.
Furthermore,
discuss
how
a
promising
potential
therapeutic
target
treatment.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(3), P. 755 - 755
Published: Feb. 11, 2019
The
mammalian
or
mechanistic
target
of
rapamycin
(mTOR)
pathway
plays
a
crucial
role
in
regulation
cell
survival,
metabolism,
growth
and
protein
synthesis
response
to
upstream
signals
both
normal
physiological
pathological
conditions,
especially
cancer.
Aberrant
mTOR
signaling
resulting
from
genetic
alterations
different
levels
the
signal
cascade
is
commonly
observed
various
types
cancers.
Upon
hyperactivation,
promotes
proliferation
metabolism
that
contribute
tumor
initiation
progression.
In
addition,
also
negatively
regulates
autophagy
via
ways.
We
discuss
its
key
downstream
factors,
specific
changes
inhibitors
applied
as
therapeutic
strategies
eight
solid
tumors.
Although
monotherapy
combination
therapy
with
have
been
extensively
preclinical
clinical
trials
cancer
types,
innovative
therapies
better
efficacy
less
drug
resistance
are
still
great
need,
new
biomarkers
deep
sequencing
technologies
will
facilitate
these
targeting
drugs
benefit
patients
personalized
therapy.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: July 6, 2022
Abstract
Ischemic
stroke
is
caused
primarily
by
an
interruption
in
cerebral
blood
flow,
which
induces
severe
neural
injuries,
and
one
of
the
leading
causes
death
disability
worldwide.
Thus,
it
great
necessity
to
further
detailly
elucidate
mechanisms
ischemic
find
out
new
therapies
against
disease.
In
recent
years,
efforts
have
been
made
understand
pathophysiology
stroke,
including
cellular
excitotoxicity,
oxidative
stress,
cell
processes,
neuroinflammation.
meantime,
a
plethora
signaling
pathways,
either
detrimental
or
neuroprotective,
are
also
highly
involved
forementioned
pathophysiology.
These
pathways
closely
intertwined
form
complex
network.
Also,
these
reveal
therapeutic
potential,
as
targeting
could
possibly
serve
approaches
stroke.
this
review,
we
describe
categorize
them
based
on
pathophysiological
processes
they
participate
in.
Therapeutic
associated
with
mentioned
above,
discussed.
Meanwhile,
clinical
trials
regarding
potentially
target
involved,
summarized
details.
Conclusively,
review
elucidated
potential
molecular
related
underlying
summarize
targeted
various
pathophysiology,
particular
reference
future
prospects
for
treating
