Molecular Cell, Journal Year: 2020, Volume and Issue: 78(6), P. 1019 - 1033
Published: June 1, 2020
Language: Английский
Science, Journal Year: 2017, Volume and Issue: 357(6352)
Published: Aug. 17, 2017
Modeling the cancer transcriptome Recent initiatives such as The Cancer Genome Atlas have mapped genome-wide effect of individual genes on tumor growth. By unraveling genomic alterations in tumors, molecular subtypes cancers been identified, which is improving patient diagnostics and treatment. Uhlen et al. developed a computer-based modeling approach to examine different types nearly 8000 patients. They provide an open-access resource for exploring how expression specific influences survival 17 cancer. More than 900,000 profiles are available, including tumors colon, prostate, lung, breast origin. This interactive data set can also be used generate personalized models predict metabolic changes influence Science , this issue p. eaan2507
Language: Английский
Citations
3030
Science Advances, Journal Year: 2016, Volume and Issue: 2(5)
Published: May 6, 2016
Researchers provide a conceptual framework to understand current knowledge of the fundamentals cancer metabolism.
Language: Английский
Citations
2516
Nature, Journal Year: 2019, Volume and Issue: 574(7779), P. 575 - 580
Published: Oct. 23, 2019
Language: Английский
Citations
2197
Science, Journal Year: 2020, Volume and Issue: 368(6487)
Published: April 9, 2020
Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but not yet resulted an effective anti therapeutic. In a Review, Faubert et al. discuss how changes develops from small, premalignant lesion to aggressive primary tumor and then metastasizes. Metabolic vulnerabilities likely change with progression, making the identification of general cancer-associated metabolic features difficult. The authors propose that more targeted approach tissues patients may be effective. Science , this issue p. eaaw5473
Language: Английский
Citations
1709
Protein & Cell, Journal Year: 2020, Volume and Issue: 12(8), P. 599 - 620
Published: Oct. 1, 2020
Abstract The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense is overexpressed in multiple human cancers. Recent studies revealed that overexpression promotes tumor growth partly through suppressing ferroptosis, a form of regulated cell death induced by excessive lipid peroxidation. However, cancer cells with high expression (SLC7A11 ) also have endure the significant cost associated SLC7A11-mediated metabolic reprogramming, leading glucose- glutamine-dependency cells, which presents potential vulnerabilities therapeutic targeting cancer. In this review, we summarize diverse regulatory mechanisms cancer, discuss ferroptosis-dependent -independent promoting development, explore mechanistic basis SLC7A11-induced nutrient dependency conceptualize strategies target treatment. This review will provide foundation further understanding dependency, biology developing novel effective therapies.
Language: Английский
Citations
1517
Cell, Journal Year: 2016, Volume and Issue: 166(3), P. 555 - 566
Published: July 1, 2016
Language: Английский
Citations
1424
Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(15), P. 10043 - 10120
Published: June 27, 2017
Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, effective way to deliver drugs specifically mitochondria is by covalent linking a lipophilic cation such an alkyltriphenylphosphonium moiety pharmacophore interest. Other delocalized cations, rhodamine, natural synthetic mitochondria-targeting peptides, nanoparticle vehicles, have also been used mitochondrial delivery small molecules. Depending on approach used, cell membrane potentials, more than 1000-fold higher concentration can be achieved. Mitochondrial targeting has developed study physiology dysfunction interaction between other subcellular organelles treatment variety diseases neurodegeneration cancer. In this Review, we discuss efforts target small-molecule compounds probing function, diagnostic tools potential therapeutics. We describe physicochemical basis accumulation chemistry strategies mitochondria, probes, sensors, examples bioactive compounds. Finally, review published attempts apply mitochondria-targeted agents cancer neurodegenerative
Language: Английский
Citations
1309
Cell Metabolism, Journal Year: 2017, Volume and Issue: 25(2), P. 262 - 284
Published: Feb. 1, 2017
Language: Английский
Citations
1267
Cell Research, Journal Year: 2017, Volume and Issue: 28(3), P. 265 - 280
Published: Dec. 8, 2017
Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view instrumental development of powerful imaging tools that are still used clinics, it is now clear mitochondria play key role oncogenesis. Besides exerting central bioenergetic functions, provide indeed building blocks tumor anabolism, control redox calcium homeostasis, participate transcriptional regulation, govern cell death. Thus, constitute promising targets novel anticancer agents. However, tumors arise, progress, respond to therapy context an intimate crosstalk with host immune system, many immunological functions rely on intact mitochondrial metabolism. Here, we review cell-intrinsic cell-extrinsic mechanisms through which influence all steps oncogenesis, focus therapeutic potential targeting metabolism therapy.
Language: Английский
Citations
1058
Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(12), P. 744 - 757
Published: Nov. 13, 2018
Language: Английский
Citations
896