Inflammation and tumor progression: signaling pathways and targeted intervention

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: July 12, 2021

Abstract Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes. Chronic inflammation facilitates progression treatment resistance, whereas induction of acute inflammatory reactions often stimulates the maturation dendritic cells (DCs) antigen presentation, leading anti-tumor immune responses. In addition, multiple signaling pathways, such as nuclear factor kappa B (NF-kB), Janus kinase/signal transducers activators transcription (JAK-STAT), toll-like receptor (TLR) cGAS/STING, mitogen-activated protein kinase (MAPK); factors, including cytokines (e.g., interleukin (IL), interferon (IFN), necrosis (TNF)-α), chemokines C-C motif chemokine ligands (CCLs) C-X-C (CXCLs)), growth factors vascular endothelial (VEGF), transforming (TGF)-β), inflammasome; well metabolites prostaglandins, leukotrienes, thromboxane, specialized proresolving mediators (SPM), have been identified pivotal regulators initiation resolution inflammation. Nowadays, local irradiation, recombinant cytokines, neutralizing antibodies, small-molecule inhibitors, DC vaccines, oncolytic viruses, TLR agonists, SPM developed specifically modulate in cancer therapy, with some these already undergoing clinical trials. Herein, we discuss crosstalk between processes. We also highlight potential targets for harnessing cancer.

Language: Английский

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Cancer metabolism: looking forward

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(10), P. 669 - 680

Published: July 16, 2021

Language: Английский

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Gut microbial metabolites as multi-kingdom intermediates

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(2), P. 77 - 94

Published: Sept. 23, 2020

Language: Английский

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The hallmarks of cancer metabolism: Still emerging

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(3), P. 355 - 377

Published: Feb. 4, 2022

Language: Английский

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Macrophages in immunoregulation and therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 22, 2023

Abstract Macrophages exist in various tissues, several body cavities, and around mucosal surfaces are a vital part of the innate immune system for host defense against many pathogens cancers. possess binary M1/M2 macrophage polarization settings, which perform central role an array tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about signaling modulation yet to uncovered. In addition, clinical importance tumor-associated macrophages is becoming more widely recognized as significant progress has been made understanding their biology. Moreover, they integral tumor microenvironment, playing regulation wide variety processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, resistance chemotherapeutic checkpoint blockade immunotherapies. Herein, we discuss signaling, mechanical stresses modulation, metabolic pathways, mitochondrial transcriptional, epigenetic regulation. Furthermore, have broadly extended traps essential roles autophagy aging regulating functions. discussed recent advances macrophages-mediated autoimmune diseases tumorigenesis. Lastly, targeted therapy portray prospective targets therapeutic strategies health diseases.

Language: Английский

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The metabolism of cancer cells during metastasis

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(3), P. 162 - 180

Published: Jan. 18, 2021

Language: Английский

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Lactate metabolism in human health and disease

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Sept. 1, 2022

Abstract The current understanding of lactate extends from its origins as a byproduct glycolysis to role in tumor metabolism, identified by studies on the Warburg effect. shuttle hypothesis suggests that plays an important bridging signaling molecule coordinates among different cells, organs and tissues. Lactylation is posttranslational modification initially reported Professor Yingming Zhao’s research group 2019. Subsequent confirmed lactylation vital component function involved proliferation, neural excitation, inflammation other biological processes. An indispensable substance for various physiological cellular functions, regulatory aspects energy metabolism signal transduction. Therefore, comprehensive review summary presented clarify disease provide reference direction future research. This offers systematic overview homeostasis roles pathological processes, well effects diseases, particularly cancer.

Language: Английский

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Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology

The Journal of Physiology, Journal Year: 2020, Volume and Issue: 599(1), P. 23 - 37

Published: Oct. 2, 2020

Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP levels. This hypoxia-induced reprogramming metabolism is key satisfying cellular energetic requirements during acute hypoxic stress. At a transcriptional level, this switch be regulated by several pathways including the hypoxia inducible factor-1α (HIF-1α) which induces an expression glycolytic enzymes. While increase in flux beneficial for maintaining bioenergetic homeostasis mediating also exploited cancer promote tumour survival and growth, area has been extensively studied. It recently become appreciated that may have profound effects on physiology immune endothelial cells. Therefore, understanding mechanisms central are importance both physiological pathophysiological standpoints. In review, we highlight role HIF-1α regulation its implications processes such as angiogenesis cell effector function.

Language: Английский

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Histone post-translational modifications — cause and consequence of genome function

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(9), P. 563 - 580

Published: March 25, 2022

Language: Английский

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Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 21(3), P. 151 - 161

Published: Aug. 24, 2020

Language: Английский

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