Hallmarks of aging: An expanding universe

Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 243 - 278

Published: Jan. 1, 2023

Language: Английский

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Effects of Intermittent Fasting on Health, Aging, and Disease

New England Journal of Medicine, Journal Year: 2019, Volume and Issue: 381(26), P. 2541 - 2551

Published: Dec. 25, 2019

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, longevity, decreased incidence of diseases, including cancer obesity.

Language: Английский

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Senescence and aging: Causes, consequences, and therapeutic avenues

The Journal of Cell Biology, Journal Year: 2017, Volume and Issue: 217(1), P. 65 - 77

Published: Nov. 7, 2017

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding biological basis of aging, research suggests that targeting aging process itself could ameliorate many age-related pathologies. Senescence a cellular response characterized by stable growth arrest other phenotypic alterations include proinflammatory secretome. plays roles in normal development, maintains tissue homeostasis, limits tumor progression. However, senescence has also been implicated as cause disease. In this regard, recent experimental evidence shown genetic or pharmacological ablation senescent cells extends life span improves health span. Here, review molecular links between discuss novel therapeutic avenues connection opens.

Language: Английский

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NAD+ metabolism and its roles in cellular processes during ageing

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(2), P. 119 - 141

Published: Dec. 22, 2020

Language: Английский

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Molecular mechanisms of dietary restriction promoting health and longevity

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 23(1), P. 56 - 73

Published: Sept. 13, 2021

Language: Английский

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mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

Gerontology, Journal Year: 2017, Volume and Issue: 64(2), P. 127 - 134

Published: Nov. 30, 2017

The mechanistic target of rapamycin (mTOR) network is an evolutionary conserved signaling hub that senses and integrates environmental intracellular nutrient growth factor signals to coordinate basic cellular organismal responses such as cell growth, proliferation, apoptosis, inflammation depending on the individual tissue. A growing list evidence suggests mTOR influences longevity aging. Inhibition complex 1 (mTORC1) with currently only known pharmacological treatment increases lifespan in all model organisms studied. This review discusses potential mechanisms how controls aging-related processes senescence, metabolism, stem function. Understanding these might provide novel therapeutic approaches influence diseases.

Language: Английский

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NAD + in Aging: Molecular Mechanisms and Translational Implications

Trends in Molecular Medicine, Journal Year: 2017, Volume and Issue: 23(10), P. 899 - 916

Published: Sept. 9, 2017

Language: Английский

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A time to fast

Science, Journal Year: 2018, Volume and Issue: 362(6416), P. 770 - 775

Published: Nov. 15, 2018

Nutrient composition and caloric intake have traditionally been used to devise optimized diets for various phases of life. Adjustment meal size frequency emerged as powerful tools ameliorate postpone the onset disease delay aging, whereas periods fasting, with or without reduced energy intake, can profound health benefits. The underlying physiological processes involve periodic shifts metabolic fuel sources, promotion repair mechanisms, optimization utilization cellular organismal health. Future research endeavors should be directed integration a balanced nutritious diet controlled patterns fasting develop better strategies prevent, postpone, treat socioeconomical burden chronic diseases associated aging.

Language: Английский

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Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(3), P. 462 - 476.e6

Published: Aug. 27, 2019

Language: Английский

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β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

Cell Reports, Journal Year: 2017, Volume and Issue: 18(9), P. 2077 - 2087

Published: Feb. 1, 2017

Highlights•Inflammation and joint pathology during gout flare is prevented by ketogenic diet•BHB inhibits IL-1β secretion from neutrophils•Ketogenic diet BHB inhibit NLRP3 activation in aged neutrophils•BHB both priming assembly steps of neutrophilsSummaryAging lipotoxicity are two major risk factors for that linked the inflammasome. Neutrophil-mediated production interleukin-1β (IL-1β) drives gouty flares cause destruction, intense pain, fever. However, metabolites impact neutrophil inflammasome remain unknown. Here, we identified (KD) increases β-hydroxybutyrate (BHB) alleviates urate crystal-induced without impairing immune defense against bacterial infection. inhibited S100A9 fibril-primed crystal-activated macrophages, which serve to recruit inflammatory neutrophils joints. Consistent with reduced rats fed a diet, blocked NLRP3-dependent manner mice humans irrespective age. Mechanistically, reducing steps. Collectively, our studies show BHB, known alternate metabolic fuel, also an anti-inflammatory molecule may as treatment gout.Graphical abstract

Language: Английский

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