Nature Cell Biology,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1571 - 1584
Published: Aug. 8, 2024
Abstract
Caloric
restriction
and
intermittent
fasting
prolong
the
lifespan
healthspan
of
model
organisms
improve
human
health.
The
natural
polyamine
spermidine
has
been
similarly
linked
to
autophagy
enhancement,
geroprotection
reduced
incidence
cardiovascular
neurodegenerative
diseases
across
species
borders.
Here,
we
asked
whether
cellular
physiological
consequences
caloric
depend
on
metabolism.
We
report
that
levels
increased
upon
distinct
regimens
or
in
yeast,
flies,
mice
volunteers.
Genetic
pharmacological
blockade
endogenous
synthesis
fasting-induced
nematodes
cells.
Furthermore,
perturbing
pathway
vivo
abrogated
lifespan-
healthspan-extending
effects,
as
well
cardioprotective
anti-arthritic
fasting.
Mechanistically,
mediated
these
effects
via
induction
hypusination
translation
regulator
eIF5A.
In
summary,
polyamine–hypusination
axis
emerges
a
phylogenetically
conserved
metabolic
control
hub
for
fasting-mediated
enhancement
longevity.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Dec. 29, 2022
Sirtuins
(SIRTs)
are
nicotine
adenine
dinucleotide(+)-dependent
histone
deacetylases
regulating
critical
signaling
pathways
in
prokaryotes
and
eukaryotes,
involved
numerous
biological
processes.
Currently,
seven
mammalian
homologs
of
yeast
Sir2
named
SIRT1
to
SIRT7
have
been
identified.
Increasing
evidence
has
suggested
the
vital
roles
members
SIRT
family
health
disease
conditions.
Notably,
this
protein
plays
a
variety
important
cellular
biology
such
as
inflammation,
metabolism,
oxidative
stress,
apoptosis,
etc.,
thus,
it
is
considered
potential
therapeutic
target
for
different
kinds
pathologies
including
cancer,
cardiovascular
disease,
respiratory
other
Moreover,
identification
modulators
exploring
functions
these
prompted
increased
efforts
discover
new
small
molecules,
which
can
modify
activity.
Furthermore,
several
randomized
controlled
trials
indicated
that
interventions
might
affect
expression
human
samples,
supplementation
diverse
impact
on
physiological
function
participants.
In
review,
we
introduce
history
structure
family,
discuss
molecular
mechanisms
elaborate
regulatory
SIRTs
summarize
inhibitors
activators,
review
related
clinical
studies.
Cell,
Journal Year:
2024,
Volume and Issue:
187(11), P. 2601 - 2627
Published: May 1, 2024
Mitochondria
reside
at
the
crossroads
of
catabolic
and
anabolic
metabolism—the
essence
life.
How
their
structure
function
are
dynamically
tuned
in
response
to
tissue-specific
needs
for
energy,
growth
repair,
renewal
is
being
increasingly
understood.
respond
intrinsic
extrinsic
stresses
can
alter
cell
organismal
by
inducing
metabolic
signaling
within
cells
distal
tissues.
Here,
we
review
how
centrality
mitochondrial
functions
manifests
health
a
broad
spectrum
diseases
aging.
Nature Aging,
Journal Year:
2022,
Volume and Issue:
3(1), P. 121 - 137
Published: Dec. 19, 2022
Abstract
The
diversity
of
cell
types
is
a
challenge
for
quantifying
aging
and
its
reversal.
Here
we
develop
‘aging
clocks’
based
on
single-cell
transcriptomics
to
characterize
cell-type-specific
rejuvenation.
We
generated
transcriptomes
from
the
subventricular
zone
neurogenic
region
28
mice,
tiling
ages
young
old.
trained
single-cell-based
regression
models
predict
chronological
age
biological
(neural
stem
proliferation
capacity).
These
clocks
are
generalizable
independent
cohorts
other
regions
brains,
species.
To
determine
if
these
could
quantify
transcriptomic
rejuvenation,
datasets
two
interventions—heterochronic
parabiosis
exercise.
Aging
revealed
that
heterochronic
exercise
reverse
in
regions,
but
different
ways.
This
study
represents
first
development
high-resolution
data
demonstrates
their
application
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: July 23, 2022
Nutriments
have
been
deemed
to
impact
all
physiopathologic
processes.
Recent
evidences
in
molecular
medicine
and
clinical
trials
demonstrated
that
adequate
nutrition
treatments
are
the
golden
criterion
for
extending
healthspan
delaying
ageing
various
species
such
as
yeast,
drosophila,
rodent,
primate
human.
It
emerges
develop
precision-nutrition
therapeutics
slow
age-related
biological
processes
treat
diverse
diseases.
However,
nutritive
advantages
frequently
diversify
among
individuals
well
organs
tissues,
which
brings
challenges
this
field.
In
review,
we
summarize
different
forms
of
dietary
interventions
extensively
prescribed
improvement
disease
treatment
pre-clinical
or
clinical.
We
discuss
nutrient-mediated
mechanisms
including
metabolic
regulators,
metabolism
pathways,
epigenetic
circadian
clocks.
Comparably,
describe
diet-responsive
effectors
by
influence
endocrinic,
immunological,
microbial
neural
states
responsible
improving
health
preventing
multiple
diseases
humans.
Furthermore,
expatiate
patterns
dietotheroapies,
fasting,
calorie-restricted
diet,
ketogenic
high-fibre
plants-based
protein
restriction
diet
with
specific
reduction
amino
acids
microelements,
potentially
affecting
morbid
states.
Altogether,
emphasize
profound
nutritional
therapy,
highlight
crosstalk
explored
critical
factors
individualized
therapeutic
approaches
predictors.
